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http://hdl.handle.net/1942/42206
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DC Field | Value | Language |
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dc.contributor.author | Demolder, Anthony | - |
dc.contributor.author | O'Neill, Louisa | - |
dc.contributor.author | El Haddad, Milad | - |
dc.contributor.author | Scherr, Daniel | - |
dc.contributor.author | VIJGEN, Johan | - |
dc.contributor.author | Wolf, Michael | - |
dc.contributor.author | Berte, Benjamin | - |
dc.contributor.author | Bisbal, Felipe | - |
dc.contributor.author | Johannessen, Arne | - |
dc.contributor.author | Rivero-Ayerza, Maximo | - |
dc.contributor.author | De Potter, Tom | - |
dc.contributor.author | De Becker, Benjamin | - |
dc.contributor.author | Polain de Waroux, Jean-Benoit le | - |
dc.contributor.author | Knecht, Sebastien | - |
dc.contributor.author | Tavernier, Rene | - |
dc.contributor.author | Duytschaever, Mattias | - |
dc.date.accessioned | 2024-01-22T11:03:09Z | - |
dc.date.available | 2024-01-22T11:03:09Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-01-19T14:32:24Z | - |
dc.identifier.citation | Circulation-Arrhythmia and Electrophysiology, 16 (11) , p. 609 -619 (Art N° e012043) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42206 | - |
dc.description.abstract | BACKGROUND: In patients with persistent atrial fibrillation (PersAF), catheter ablation aiming for pulmonary vein isolation (PVI) is associated with moderate clinical effectiveness. We investigated the benefit of continuing previously ineffective class 1C or 3 antiarrhythmic drug therapy (ADT) in the setting of a standardized PVI-only ablation strategy.METHODS: In this multicenter, randomized controlled study, patients with PersAF (>= 7 days and <12 months) despite ADT were prospectively randomized 1:1 to PVI with ADT continued versus discontinued beyond the blanking period (ADT ON versus ADT OFF). Standardized catheter ablation was performed aiming for durable isolation with stable, contiguous, and optimized radio frequency applications encircling the pulmonary veins (CLOSE protocol). Clinical visits and 1-to-7-day Holter were performed at 3, 6, and 12 months. The primary end point was any documented atrial tachyarrhythmia lasting >30 seconds beyond 3 months. Prospectively defined secondary end points included repeat ablations, unscheduled arrhythmia-related visits, and quality of life among groups.RESULTS: Of 200 PersAF patients, 98 were assigned to ADT OFF and 102 to ADT ON. The longest atrial fibrillation episode qualifying for PersAF was 28 (10-90) versus 30 (11-90) days. Clinical characteristics and procedural characteristics were similar. Recurrence of atrial tachyarrhythmia was comparable in both groups (20% OFF versus 21.2% ON). No differences were observed in repeat ablations and unscheduled arrhythmia-related visits. Marked improvement in quality of life was observed in both groups.CONCLUSIONS: In patients with PersAF, there is no benefit in continuing previously ineffective ADT beyond the blanking period after catheter ablation. The high success rate of PVI-only might be explained by the high rate of durable isolation after optimized PVI and the early stage of PersAF (POWDER-AF2). | - |
dc.description.sponsorship | Biosense-Webster Inc. [IIS-479] | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | 2023 American Heart Association, Inc. | - |
dc.subject.other | antiarrhythmia agents | - |
dc.subject.other | atrial fibrillation | - |
dc.subject.other | catheter ablation | - |
dc.subject.other | pulmonary veins | - |
dc.subject.other | treatment outcome | - |
dc.title | No Effect of Continued Antiarrhythmic Drug Treatment on Top of Optimized Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation: Results From the POWDER-AF2 Trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 619 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 609 | - |
dc.identifier.volume | 16 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Demolder, A (corresponding author), Sint Jan Dept Cardiol, Ruddershove 10, B-8000 Brugge, Belgium. | - |
dc.description.notes | anthony.demolder@gmail.com; louisa.oneill@kcl.ac.uk; | - |
dc.description.notes | milad.elhaddad@emdt.eu; daniel.scherr@medunigraz.at; | - |
dc.description.notes | johan.vijgen@jessazh.be; michael.wolf@zna.be; | - |
dc.description.notes | benjamin.debecker@azsintjan.be; f.bisbalvb@gmail.com; | - |
dc.description.notes | arne.johannessen@regionh.dk; maximo.rivero@zol.be; | - |
dc.description.notes | tom.de.potter@olvz-aalst.be; benjamin.debecker@azsintjan.be; | - |
dc.description.notes | Jean-Benoit.LePolainDeWaroux@azsintjan.be; | - |
dc.description.notes | sebastien.knecht@azsintjan.be; rene.tavernier@azsintjan.be; | - |
dc.description.notes | Mattias.Duytschaever@azsintjan.be | - |
local.publisher.place | TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e012043 | - |
dc.identifier.doi | 10.1161/CIRCEP.123.012043 | - |
dc.identifier.isi | 001106495100001 | - |
dc.identifier.isi | 37921006 | - |
dc.contributor.orcid | Bisbal, Felipe/0000-0002-4843-7063; Wolf, Michael/0000-0003-1804-8697; | - |
dc.contributor.orcid | Demolder, Anthony/0000-0002-1531-6396; El Haddad, | - |
dc.contributor.orcid | Milad/0000-0001-9436-7820; vijgen, johan/0000-0003-4928-4836; | - |
dc.contributor.orcid | johannessen, arne/0000-0003-0294-3750 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Demolder, Anthony] Sint Jan Dept Cardiol, Ruddershove 10, B-8000 Brugge, Belgium. | - |
local.description.affiliation | [Demolder, Anthony; O'Neill, Louisa; El Haddad, Milad; De Becker, Benjamin; Polain de Waroux, Jean-Benoit le; Knecht, Sebastien; Tavernier, Rene; Duytschaever, Mattias] Acad Hosp St Jan, Dept Cardiol, Brugge, Belgium. | - |
local.description.affiliation | [Scherr, Daniel] Med Univ Graz, Dept Cardiol, Graz, Austria. | - |
local.description.affiliation | [Vijgen, Johan] Jessa Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Wolf, Michael] ZNA Middelheim, Dept Cardiol, Antwerp, Belgium. | - |
local.description.affiliation | [Berte, Benjamin] Luzerner Kantonsspital, Dept Cardiol, Luzern, Switzerland. | - |
local.description.affiliation | [Bisbal, Felipe] Hosp Badalona Germans Trias & Pujol, Dept Clin Pharmacol, Barcelona, Spain. | - |
local.description.affiliation | [Johannessen, Arne] Herlev & Gentofte Hosp, Dept Cardiol, Hellerup, Denmark. | - |
local.description.affiliation | [Rivero-Ayerza, Maximo] Ziekenhuis Oost Limburg, Dept Cardiol, Genk, Belgium. | - |
local.description.affiliation | [De Potter, Tom] OLV Hosp Aalst, Dept Cardiol, Aalst, Belgium. | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.fullcitation | Demolder, Anthony; O'Neill, Louisa; El Haddad, Milad; Scherr, Daniel; VIJGEN, Johan; Wolf, Michael; Berte, Benjamin; Bisbal, Felipe; Johannessen, Arne; Rivero-Ayerza, Maximo; De Potter, Tom; De Becker, Benjamin; Polain de Waroux, Jean-Benoit le; Knecht, Sebastien; Tavernier, Rene & Duytschaever, Mattias (2023) No Effect of Continued Antiarrhythmic Drug Treatment on Top of Optimized Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation: Results From the POWDER-AF2 Trial. In: Circulation-Arrhythmia and Electrophysiology, 16 (11) , p. 609 -619 (Art N° e012043). | - |
item.fulltext | With Fulltext | - |
item.contributor | Demolder, Anthony | - |
item.contributor | O'Neill, Louisa | - |
item.contributor | El Haddad, Milad | - |
item.contributor | Scherr, Daniel | - |
item.contributor | VIJGEN, Johan | - |
item.contributor | Wolf, Michael | - |
item.contributor | Berte, Benjamin | - |
item.contributor | Bisbal, Felipe | - |
item.contributor | Johannessen, Arne | - |
item.contributor | Rivero-Ayerza, Maximo | - |
item.contributor | De Potter, Tom | - |
item.contributor | De Becker, Benjamin | - |
item.contributor | Polain de Waroux, Jean-Benoit le | - |
item.contributor | Knecht, Sebastien | - |
item.contributor | Tavernier, Rene | - |
item.contributor | Duytschaever, Mattias | - |
crisitem.journal.issn | 1941-3149 | - |
crisitem.journal.eissn | 1941-3084 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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demolder-et-al-2023-no-effect-of-continued-antiarrhythmic-drug-treatment-on-top-of-optimized-pulmonary-vein-isolation.pdf | Published version | 1.22 MB | Adobe PDF | View/Open |
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