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Title: | High proportions of post-exertional malaise and orthostatic intolerance in people living with post-COVID-19 condition: the PRIME post-COVID study | Authors: | Pagen, Demi M. E. VAN HERCK, Maarten van Bilsen, Celine J. A. Brinkhues, Stephanie Konings , Kevin den Heijer, Casper D. J. SPRUIT, Martijn A. Hoebe, Christian J. P. A. Dukers-Muijrers, Nicole H. T. M. |
Issue Date: | 2023 | Publisher: | FRONTIERS MEDIA SA | Source: | Frontiers in Medicine, 10 (Art N° 1292446) | Abstract: | BackgroundExercise-based treatments can worsen/exacerbate symptoms in people who were SARS-CoV-2 positive and living with post-COVID-19 condition (PL-PCC) and who have post-exertional malaise (PEM) or orthostatic intolerance (OI). Nevertheless, PEM and OI are not routinely assessed by clinicians. We estimated PEM and OI proportions in PL-PCC, as well as in people not living with PCC (PnL-PCC) and negatives (i.e., never reported a SARS-CoV-2 positive test), and identified associated factors.MethodsParticipants from the Prevalence, Risk factors, and Impact Evaluation (PRIME) post-COVID-19 condition study were included. PEM and OI were assessed using validated questionnaires. PCC was defined as feeling unrecovered after SARS-CoV-2 infection. Multivariable regression analyses to study PEM and OI were stratified for sex.ResultsData from 3,783 participants were analyzed. In PL-PCC, the proportion of PEM was 48.1% and 41.2%, and the proportion of OI was 29.3% and 27.9% in women and men, respectively. Proportions were higher in PL-PCC than negatives, for PEM in women OR=4.38 [95%CI:3.01-6.38]; in men OR = 4.78 [95%CI:3.13-7.29]; for OI in women 3.06 [95%CI:1.97-4.76]; in men 2.71 [95%CI:1.75-4.21]. Associated factors were age <= 60 years, >= 1 comorbidities, and living alone.ConclusionHigh proportions of PEM and OI are observed in PL-PCC. Standard screening for PEM and OI is recommended in PL-PCC to promote appropriate therapies. | Notes: | Pagen, DME (corresponding author), South Limburg Publ Hlth Serv, Living Lab Publ Hlth, Dept Sexual Hlth Infect Dis & Environm Hlth, Heerlen, Netherlands.; Pagen, DME (corresponding author), Maastricht Univ, Care & Publ Hlth Res Inst CAPHRI, Dept Social Med, Maastricht, Netherlands. Demi.Pagen@ggdzl.nl |
Keywords: | COVID-19;long COVID;post-COVID-19 condition;post-exertional malaise;orthostatic intolerance | Document URI: | http://hdl.handle.net/1942/42212 | e-ISSN: | 2296-858X | DOI: | 10.3389/fmed.2023.1292446 | ISI #: | 001133005000001 | Rights: | 2023 Pagen, Van Herck, van Bilsen, Brinkhues, Konings, den Heijer, Spruit, Hoebe and Dukers-Muijrers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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the PRIME post-COVID study.pdf | Published version | 1.36 MB | Adobe PDF | View/Open |
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