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http://hdl.handle.net/1942/42220
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DC Field | Value | Language |
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dc.contributor.author | KREMER, Cécile | - |
dc.contributor.author | TORNERI, Andrea | - |
dc.contributor.author | LIBIN, Pieter | - |
dc.contributor.author | Meex, C | - |
dc.contributor.author | Hayette, MP | - |
dc.contributor.author | Bontems, S | - |
dc.contributor.author | Durkin, K | - |
dc.contributor.author | Artesi, M | - |
dc.contributor.author | Bours, V | - |
dc.contributor.author | Lemey, P | - |
dc.contributor.author | Darcis, G | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Meuris, C | - |
dc.date.accessioned | 2024-01-23T10:03:02Z | - |
dc.date.available | 2024-01-23T10:03:02Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-01-15T13:59:42Z | - |
dc.identifier.citation | Epidemics, 44 (Art N° 100701) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42220 | - |
dc.description.abstract | Mathematicalmodelling studies have shown that repetitive screening canbeused tomitigate SARS-CoV2 transmission inprimary schoolswhile keeping schools open. However, notmuch is knownabout how transmissionprogresseswithin schools andwhether there is a riskof importation tohouseholds. During theacademicyear2020–2021, aprospectivesurveillancestudyusingrepetitivescreeningwasconductedin aprimary school andassociatedhouseholds inLiège (Belgium). SARS-CoV-2 screeningwas performedvia throatwashingeitheronceor twiceaweek.Weusedgenomicandepidemiological data toreconstruct the observedschooloutbreaksusingtwodifferentmodels.Theoutbreaker2model combines informationonthe generationtimeandcontactpatternswithamodelofsequenceevolution.ForcomparisonwealsousedSCOTTI, aphylogeneticmodel basedon the structuredcoalescent. Inaddition,weperformeda simulationstudy to investigatehowtheaccuracyofestimatedpositivityratesinaschooldependsontheproportionofaschoolthat issampledinarepetitivescreeningstrategy.WefoundnodifferenceinSARS-CoV-2positivitybetweenchildren andadults andchildrenwerenotmoreoftenasymptomaticcompared toadults. Bothmodels foroutbreak reconstruction revealed that transmissionoccurredmainlywithin the school environment. Uncertainty in outbreakreconstructionwas lowestwhenincludinggenomicaswellasepidemiologicaldata.Wefoundthat observedweeklypositivityrates areagoodapproximation to the trueweeklypositivityrate, especially in children, evenwhenonly25%of theschool populationis sampled.Theseresults indicate that, inaddition to reducing infections as shown inmodelling studies, repetitive screening inschool settings can lead toa betterunderstandingof theextentof transmissioninschoolsduringapandemicandimportationriskat the communitylevel. | - |
dc.description.sponsorship | Funding The studywas fundedbyFondationLéonFredericqandby the LiègeUniversityHospitalResearchfunds.P.J.K.L.gratefullyacknowledges support fromtheResearchFoundation Flanders (FWO), Belgiumviapostdoctoral fellowship1242021N(P.J.K.L.). P.J.K.L. also acknowledgessupport fromtheResearchcouncilof theVrijeUniversiteit Brussel (OZR-VUB), Belgiumvia grant numberOZR3863BOF, andfromtheFlemishGovernment throughtheAIResearchProgram. G.D. isanFNRSpostdoctoral clinicalmaster specialist.P.L. acknowledges support by the EuropeanResearchCouncil under the EuropeanUnion’sHorizon2020researchandinnovationprogramme(grant agreementnumber725422-ReservoirDOCS)andtheResearchFoundation–Flanders (‘FondsvoorWetenschappelijkOnderzoek–Vlaanderen’, G066215N, G0D5117NandG0B9317N). N.H. andA.T. acknowledgefundingfromtheEuropeanUnion’sHorizon2020research andinnovationprogramme-projectEpiPose(Grantagreementnumber 101003688). This projectwas supportedby theVERDI project (101045989), fundedbytheEuropeanUnion.Viewsandopinionsexpressedarehoweverthoseoftheauthor(s)onlyanddonotnecessarily reflectthoseoftheEuropeanUnionortheHealthandDigitalExecutive Agency.NeithertheEuropeanUnionnorthegrantingauthoritycanbe heldresponsibleforthem. Acknowledgements Thecomputational resourcesandservicesusedinthisworkwere providedbytheVSC(FlemishSupercomputerCenter), fundedbythe ResearchFoundationFlanders (FWO) and the FlemishGovernment departmentEWI. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | 2023TheAuthors.PublishedbyElsevierB.V.ThisisanopenaccessarticleundertheCCBYlicense(http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | SARS-coV-2 transmission | - |
dc.subject.other | Primary school | - |
dc.subject.other | Outbreak reconstruction | - |
dc.subject.other | Whole genome sequences | - |
dc.subject.other | Screening protocol | - |
dc.title | Reconstruction of SARS-CoV-2 outbreaks in a primary school using epidemiological and genomic data | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 44 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 100701 | - |
local.relation.h2020 | 725422 | - |
dc.identifier.doi | 10.1016/j.epidem.2023.100701 | - |
dc.identifier.isi | WOS:001053794500001 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | no | - |
local.relation.horizonEurope | 101003688 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | KREMER, Cécile; TORNERI, Andrea; LIBIN, Pieter; Meex, C; Hayette, MP; Bontems, S; Durkin, K; Artesi, M; Bours, V; Lemey, P; Darcis, G; HENS, Niel & Meuris, C (2023) Reconstruction of SARS-CoV-2 outbreaks in a primary school using epidemiological and genomic data. In: Epidemics, 44 (Art N° 100701). | - |
item.contributor | KREMER, Cécile | - |
item.contributor | TORNERI, Andrea | - |
item.contributor | LIBIN, Pieter | - |
item.contributor | Meex, C | - |
item.contributor | Hayette, MP | - |
item.contributor | Bontems, S | - |
item.contributor | Durkin, K | - |
item.contributor | Artesi, M | - |
item.contributor | Bours, V | - |
item.contributor | Lemey, P | - |
item.contributor | Darcis, G | - |
item.contributor | HENS, Niel | - |
item.contributor | Meuris, C | - |
crisitem.journal.issn | 1755-4365 | - |
crisitem.journal.eissn | 1878-0067 | - |
Appears in Collections: | Research publications |
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1-s2.0-S1755436523000373-main.pdf | Published version | 1.64 MB | Adobe PDF | View/Open |
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