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http://hdl.handle.net/1942/42286
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DC Field | Value | Language |
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dc.contributor.author | Pierreux, Jan | - |
dc.contributor.author | Bottieau, Emmanuel | - |
dc.contributor.author | Florence, Eric | - |
dc.contributor.author | Maniewski, Ula | - |
dc.contributor.author | Bruggemans, Anne | - |
dc.contributor.author | Malotaux, Jiska | - |
dc.contributor.author | Martin, Charlotte | - |
dc.contributor.author | COX, Janneke | - |
dc.contributor.author | Konopnicki, Deborah | - |
dc.contributor.author | Guetens, Pieter | - |
dc.contributor.author | Verschueren, Jacob | - |
dc.contributor.author | Coppens, Jasmine | - |
dc.contributor.author | Van Esbroeck, Marjan | - |
dc.contributor.author | Mutsaers, Mathijs | - |
dc.contributor.author | Rosanas-Urgell, Anna | - |
dc.date.accessioned | 2024-01-31T12:41:24Z | - |
dc.date.available | 2024-01-31T12:41:24Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-01-31T10:13:58Z | - |
dc.identifier.citation | JOURNAL OF TRAVEL MEDICINE, 31 (3) (Art N° taad165) | - |
dc.identifier.issn | 1195-1982 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42286 | - |
dc.description.abstract | Background Failure of artemisinin-based combination therapy is increasingly reported in patients with Plasmodium falciparum malaria in sub-Saharan Africa. We aimed to describe the clinical and genomic characteristics of recent cases of P. falciparum malaria failing artemether-lumefantrine in Belgium.Methods Travel-related cases of malaria confirmed at the national reference laboratory of the Institute of Tropical Medicine, Antwerp, Belgium, were reviewed. All cases for which attending clinicians reported persistence (beyond Day 3 post-treatment initiation, i.e. early failure) or recrudescence (from Day 7 to 42, i.e. late failure) of P. falciparum parasites despite adequate drug intake were analysed. Both initial and persistent/recurrent samples were submitted to next generation sequencing to investigate resistance-conferring mutations.Results From July 2022 to June 2023, eight P. falciparum cases of failure with artemether-lumefantrine therapy were reported (early failure = 1; late failure = 7). All travellers were returning from sub-Saharan Africa, most (6/8) after a trip to visit friends and relatives. PfKelch13 (PF3D7_1343700) mutations associated with resistance to artemisinin were found in two travellers returning from East Africa, including the validated marker R561H in the patient with early failure and the candidate marker A675V in a patient with late failure. Additional mutations were detected that could contribute to decreased susceptibility to artemisinin in another three cases, lumefantrine in six cases and proguanil in all eight participants. Various regimens were used to treat the persistent/recrudescent cases, with favourable outcome.Conclusion Within a 12-month period, we investigated eight travellers returning from sub-Saharan Africa with P. falciparum malaria and in whom artemether-lumefantrine failure was documented. Mutations conferring resistance to antimalarials were found in all analysed blood samples, especially against lumefantrine and proguanil, but also artemisinin. There is a pressing need for systematic genomic surveillance of resistance to antimalarials in international travellers with P. falciparum malaria, especially those experiencing treatment failure. | - |
dc.description.sponsorship | Funding This work was performed within the surveillance duties of the national reference laboratory for tropical diseases of the ITM, with the support of the national insurance system. Genomic analysis of all samples was performed with Malariology unit funding to A.R.U. Acknowledgements The authors thank all colleagues from Belgian laboratories for sending malaria positive samples to the national reference laboratory of ITM on a voluntary basis. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.rights | International Society of Travel Medicine 2023. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com Open access | - |
dc.subject.other | Malaria genomic surveillance | - |
dc.subject.other | travel | - |
dc.subject.other | artemisinin-based combination therapy | - |
dc.subject.other | failure | - |
dc.subject.other | drug resistance | - |
dc.title | Failure of artemether-lumefantrine therapy in travellers returning to Belgium with Plasmodium falciparum malaria: an observational case series with genomic analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 3 | - |
dc.identifier.volume | 31 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Pierreux, J (corresponding author), Univ Libre Bruxelles, St Pierre Univ Hosp, Infect Dis Dept, B-1000 Brussels, Belgium. | - |
dc.description.notes | jan.pierreux@uzbrussel.be; eric.florence@uza.be; umaniewski@itg.be; | - |
dc.description.notes | Anne.Bruggemans@jessazh.be; Jiska.Malotaux@uzgent.be; | - |
dc.description.notes | charlotte.martin@stpierre-bru.be; Janneke.Cox@jessazh.be; | - |
dc.description.notes | deborah.konopnicki@stpierre-bru.be; pguetens@itg.be; | - |
dc.description.notes | jverschueren@itg.be; jcoppens@itg.be; mvesbroeck@itg.be; | - |
dc.description.notes | mmutsaers@itg.be; arosanas@itg.be | - |
local.publisher.place | JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | taad165 | - |
dc.identifier.doi | 10.1093/jtm/taad165 | - |
dc.identifier.pmid | 38157311 | - |
dc.identifier.isi | 001145605400001 | - |
dc.contributor.orcid | MUTSAERS, MATHIJS/0000-0002-7633-6438; Bruggemans, | - |
dc.contributor.orcid | Anne/0000-0001-5941-9701; Martin, Charlotte/0000-0002-8995-6230 | - |
dc.identifier.eissn | 1708-8305 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Pierreux, Jan; Martin, Charlotte; Konopnicki, Deborah] Univ Libre Bruxelles, St Pierre Univ Hosp, Infect Dis Dept, B-1000 Brussels, Belgium. | - |
local.description.affiliation | [Bottieau, Emmanuel; Maniewski, Ula; Bruggemans, Anne; Verschueren, Jacob; Coppens, Jasmine; Van Esbroeck, Marjan; Mutsaers, Mathijs] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Florence, Eric] Univ Hosp Antwerp, Dept Gen Internal Med & Infect Dis, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Malotaux, Jiska] Ghent Univ Hosp, Dept Gen Internal Med & Infect Dis, B-9000 Ghent, Belgium. | - |
local.description.affiliation | [Cox, Janneke] Jessa Hosp, Dept Infect Dis & Immun, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Cox, Janneke] Univ Hasselt, Fac Med & Life Sci, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Guetens, Pieter; Mutsaers, Mathijs; Rosanas-Urgell, Anna] Inst Trop Med, Dept Biomed Sci, B-2000 Antwerp, Belgium. | - |
local.uhasselt.international | no | - |
item.accessRights | Open Access | - |
item.fullcitation | Pierreux, Jan; Bottieau, Emmanuel; Florence, Eric; Maniewski, Ula; Bruggemans, Anne; Malotaux, Jiska; Martin, Charlotte; COX, Janneke; Konopnicki, Deborah; Guetens, Pieter; Verschueren, Jacob; Coppens, Jasmine; Van Esbroeck, Marjan; Mutsaers, Mathijs & Rosanas-Urgell, Anna (2023) Failure of artemether-lumefantrine therapy in travellers returning to Belgium with Plasmodium falciparum malaria: an observational case series with genomic analysis. In: JOURNAL OF TRAVEL MEDICINE, 31 (3) (Art N° taad165). | - |
item.fulltext | With Fulltext | - |
item.contributor | Pierreux, Jan | - |
item.contributor | Bottieau, Emmanuel | - |
item.contributor | Florence, Eric | - |
item.contributor | Maniewski, Ula | - |
item.contributor | Bruggemans, Anne | - |
item.contributor | Malotaux, Jiska | - |
item.contributor | Martin, Charlotte | - |
item.contributor | COX, Janneke | - |
item.contributor | Konopnicki, Deborah | - |
item.contributor | Guetens, Pieter | - |
item.contributor | Verschueren, Jacob | - |
item.contributor | Coppens, Jasmine | - |
item.contributor | Van Esbroeck, Marjan | - |
item.contributor | Mutsaers, Mathijs | - |
item.contributor | Rosanas-Urgell, Anna | - |
crisitem.journal.issn | 1195-1982 | - |
crisitem.journal.eissn | 1708-8305 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Failure of artemether-lumefantrine therapy in travellers returning to Belgium with Plasmodium falciparum malaria.pdf | Published version | 741.01 kB | Adobe PDF | View/Open |
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