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http://hdl.handle.net/1942/42294
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DC Field | Value | Language |
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dc.contributor.author | Meulemans, Jeroen | - |
dc.contributor.author | Werpin, Louis | - |
dc.contributor.author | Hermans , Robert | - |
dc.contributor.author | LAENEN, Annouschka | - |
dc.contributor.author | Nuyts , Sandra | - |
dc.contributor.author | Clement, Paul M. | - |
dc.contributor.author | Delaere, Pierre | - |
dc.contributor.author | Van Lierde, Charlotte | - |
dc.contributor.author | Vander Poorten, Vincent | - |
dc.date.accessioned | 2024-02-01T10:56:30Z | - |
dc.date.available | 2024-02-01T10:56:30Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-02-01T10:39:41Z | - |
dc.identifier.citation | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, | - |
dc.identifier.uri | http://hdl.handle.net/1942/42294 | - |
dc.description.abstract | PurposeRadiological extranodal extension (rENE) is a well-known negative prognosticator in head and neck squamous cell carcinoma (HNSCC). However, controversy remains regarding the prognostic effect of rENE in HPV-positive oropharyngeal SCCs (OPSCC). This single-center retrospective cohort analysis assessed the prognostic role of rENE in an HPV + OPSCC population and tried to validate a recently proposed modification of the TNM8 N-classification.Methods129 patients with HPV + OPSCC, of whom 106 cN + patients, were included. Radiological imaging (CT, MRI or both) was reanalyzed by a senior head and neck radiologist. Overall survival (OS), disease-free survival (DFS), locoregional recurrence-free survival (LRFS), and disease-specific survival (DSS) were evaluated. Cox proportional hazard models were used for estimating hazard ratios (HR).ResultsA non-significant trend towards better outcomes in the rENE- group, as compared to the rENE + population, was observed for 5 year OS [80.99% vs 68.70%, HR: 2.05, p = 0.160], 5 year RFS [78.81% vs 67.87%, HR: 1.91, p = 0.165], 5 year DFS [77.06% vs 60.16%, HR: 2.12, p = 0.0824] and 5 year DSS [88.83% vs 81.93%, HR: 2.09, p = 0.195]. OS declined with ascending levels of rENE (p = 0.020). Multivariate analysis identified cT-classification and smoking as independent negative predictors for OS/DFS. The proposed modification of the TNM8 N-classification could not be validated.ConclusionsAlthough rENE could not be identified as an independent negative prognosticator for outcome in our HPV + OPSCC population, outcomes tend to deteriorate with increasing rENE. | - |
dc.description.sponsorship | Partial fnancial support was received from the Walter Vandeputte Hoofd-Halskanker Fonds. S.N. is supported by a clinical research mandate from the Flemish Foundation of Scientifc Research (FWO-Vlaanderen, 18B4122N). | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.rights | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024 | - |
dc.subject.other | Radiological extranodal extension (rENE) | - |
dc.subject.other | Human papillomavirus (HPV) | - |
dc.subject.other | Oropharyngeal squamous cell carcinoma (OPSCC) | - |
dc.subject.other | Prognostic effect | - |
dc.subject.other | Outcomes | - |
dc.title | The prognostic effect of radiological extranodal extension in HPV-positive oropharyngeal squamous cell carcinomas: a retrospective cohort analysis | - |
dc.type | Journal Contribution | - |
local.format.pages | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Meulemans, J (corresponding author), Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Herestr 49, B-3000 Leuven, Belgium.; Meulemans, J (corresponding author), Katholieke Univ Leuven, Dept Oncol Sect Head & Neck Oncol, Leuven, Belgium. | - |
dc.description.notes | jeroen.meulemans@uzleuven.be | - |
local.publisher.place | ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1007/s00405-023-08409-8 | - |
dc.identifier.pmid | 38170212 | - |
dc.identifier.isi | 001135709900002 | - |
dc.contributor.orcid | Vander Poorten, Vincent/0000-0003-1341-829X; nuyts, | - |
dc.contributor.orcid | sandra/0000-0002-5540-4796; Laenen, Annouschka/0000-0002-1371-442X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Meulemans, Jeroen; Werpin, Louis; Delaere, Pierre; Van Lierde, Charlotte; Vander Poorten, Vincent] Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Herestr 49, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Meulemans, Jeroen; Van Lierde, Charlotte; Vander Poorten, Vincent] Katholieke Univ Leuven, Dept Oncol Sect Head & Neck Oncol, Leuven, Belgium. | - |
local.description.affiliation | [Hermans, Robert] Univ Hosp Leuven, Radiol, Leuven, Belgium. | - |
local.description.affiliation | [Laenen, Annouschka] Interuniv Inst Biostat & Stat Bioinformat, Louvain, Belgium. | - |
local.description.affiliation | [Nuyts, Sandra] Katholieke Univ Leuven, Lab Expt Radiotherapy, Leuven, Belgium. | - |
local.description.affiliation | [Clement, Paul M.] Univ Hosp Leuven, Med Oncol, Leuven, Belgium. | - |
local.description.affiliation | [Nuyts, Sandra] Univ Hosp Leuven, Radiat Oncol, Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.contributor | Meulemans, Jeroen | - |
item.contributor | Werpin, Louis | - |
item.contributor | Hermans , Robert | - |
item.contributor | LAENEN, Annouschka | - |
item.contributor | Nuyts , Sandra | - |
item.contributor | Clement, Paul M. | - |
item.contributor | Delaere, Pierre | - |
item.contributor | Van Lierde, Charlotte | - |
item.contributor | Vander Poorten, Vincent | - |
item.fullcitation | Meulemans, Jeroen; Werpin, Louis; Hermans , Robert; LAENEN, Annouschka; Nuyts , Sandra; Clement, Paul M.; Delaere, Pierre; Van Lierde, Charlotte & Vander Poorten, Vincent (2024) The prognostic effect of radiological extranodal extension in HPV-positive oropharyngeal squamous cell carcinomas: a retrospective cohort analysis. In: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY,. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0937-4477 | - |
crisitem.journal.eissn | 1434-4726 | - |
Appears in Collections: | Research publications |
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s00405-023-08409-8.pdf Restricted Access | Early view | 1.26 MB | Adobe PDF | View/Open Request a copy |
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