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http://hdl.handle.net/1942/42333
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DC Field | Value | Language |
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dc.contributor.author | HAESEN, Sibren | - |
dc.contributor.author | JAGER, Manon Marie | - |
dc.contributor.author | Brillouet, Aline | - |
dc.contributor.author | DE LAAT, Iris | - |
dc.contributor.author | VASTMANS, Lotte | - |
dc.contributor.author | VERGHOTE, Eline | - |
dc.contributor.author | DELAET, Anouck | - |
dc.contributor.author | D'HAESE, Sarah | - |
dc.contributor.author | HAMAD, Ibrahim | - |
dc.contributor.author | KLEINEWIETFELD, Markus | - |
dc.contributor.author | MEBIS, Jeroen | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | WOLFS, Esther | - |
dc.contributor.author | DELUYKER, Dorien | - |
dc.contributor.author | BITO, Virginie | - |
dc.date.accessioned | 2024-02-07T10:21:44Z | - |
dc.date.available | 2024-02-07T10:21:44Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-01-19T08:35:32Z | - |
dc.identifier.citation | Antioxidants, 13 (1) (Art N° 112) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42333 | - |
dc.description.abstract | The use of doxorubicin (DOX) chemotherapy is restricted due to dose-dependent cardiotoxicity. Pyridoxamine (PM) is a vitamin B6 derivative with favorable effects on diverse cardiovascular diseases, suggesting a cardioprotective effect on DOX-induced cardiotoxicity. The cardioprotective nature of PM was investigated in a rat model of DOX-induced cardiotoxicity. Six-week-old female Sprague Dawley rats were treated intravenously with 2 mg/kg DOX or saline (CTRL) weekly for eight weeks. Two other groups received PM via the drinking water next to DOX (DOX+PM) or saline (CTRL+PM). Echocardiography, strain analysis, and hemodynamic measurements were performed to evaluate cardiac function. Fibrotic remodeling, myocardial inflammation, oxidative stress, apoptosis, and ferroptosis were evaluated by various in vitro techniques. PM significantly attenuated DOX-induced left ventricular (LV) dilated cardiomyopathy and limited TGF-β1-related LV fibrotic remodeling and macrophage-driven myocardial inflammation. PM protected against DOX-induced ferroptosis, as evidenced by restored DOX-induced disturbance of redox balance, improved cytosolic and mitochondrial iron regulation, and reduced mitochondrial damage at the gene level. In conclusion, PM attenuated the development of cardiac damage after DOX treatment by reducing myocardial fibrosis, inflammation, and mitochondrial damage and by restoring redox and iron regulation at the gene level, suggesting that PM may be a novel cardioprotective strategy for DOX-induced cardiomyopathy. | - |
dc.description.sponsorship | This research was funded by the Flemish Fund for Scientific Research (FWO Flanders, Brussels, Belgium) with grant numbers 1196221N and G040220FWO, UHasselt Special Research Fund (BOF19KP07) and Limburg Cancer Foundation. Acknowledgments We thank Jeanine Santermans for embedding the tissues in paraffin. The authors also thank Marc Jans and Wendy Vandendries for their skillful technical assistance with transmission electron microscopy and Melissa Jans and Yennick Geuens regarding animal housing. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | anthracyclines | - |
dc.subject.other | cardiotoxicity | - |
dc.subject.other | pyridoxamine | - |
dc.subject.other | cardioprotection | - |
dc.subject.other | preclinical study | - |
dc.subject.other | inflammation | - |
dc.subject.other | redox biology | - |
dc.subject.other | mitochondria | - |
dc.title | Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bito, V (corresponding author), UHasselt, Fac Med & Life Sci, Biomed Res Inst BIOMED, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | sibren.haesen@uhasselt.be; manonmarie.jager@uliege.be; | - |
dc.description.notes | alinebrillouet@hotmail.com; iris.delaat2000@gmail.com; | - |
dc.description.notes | lotte.vastmans@student.uhasselt.be; everghote@hotmail.be; | - |
dc.description.notes | anouk.delaet@student.uhasselt.be; sarah.dhaese@uhasselt.be; | - |
dc.description.notes | ibrahim.hamad@uhasselt.vib.be; markus.kleinewietfeld@uhasselt.vib.be; | - |
dc.description.notes | jeroen.mebis@uhasselt.be; wilfried.mullens@uhasselt.be; | - |
dc.description.notes | ivo.lambrichts@uhasselt.be; esther.wolfs@uhasselt.be; | - |
dc.description.notes | dorien.deluyker@uhasselt.be; virginie.bito@uhasselt.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 112 | - |
dc.identifier.doi | 10.3390/antiox13010112 | - |
dc.identifier.doi | 001149320900001 | - |
dc.identifier.pmid | 38247537 | - |
dc.identifier.isi | WOS:001149320900001 | - |
dc.identifier.url | https://www.mdpi.com/2076-3921/13/1/112 | - |
dc.identifier.eissn | 2076-3921 | - |
local.provider.type | CrossRef | - |
local.description.affiliation | [Haesen, Sibren; Jager, Manon Marie; Brillouet, Aline; de Laat, Iris; Vastmans, Lotte; Verghote, Eline; Delaet, Anouk; D'Haese, Sarah; Hamad, Ibrahim; Kleinewietfeld, Markus; Mebis, Jeroen; Mullens, Wilfried; Lambrichts, Ivo; Wolfs, Esther; Deluyker, Dorien; Bito, Virginie] UHasselt, Fac Med & Life Sci, Biomed Res Inst BIOMED, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [D'Haese, Sarah] Univ Maastricht, Cardiovasc Res Inst Maastricht CARIM, Sch Cardiovasc Dis, Univ Singel 50, NL-6229 ER Maastricht, Netherlands. | - |
local.description.affiliation | [Hamad, Ibrahim; Kleinewietfeld, Markus] Hasselt Univ, VIB Ctr Inflammat Res IRC, VIB Lab Translat Immunomodulat, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Mebis, Jeroen] Jessa Hosp, Dept Med Oncol, Stadsomvaart 11, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | HAESEN, Sibren; JAGER, Manon Marie; Brillouet, Aline; DE LAAT, Iris; VASTMANS, Lotte; VERGHOTE, Eline; DELAET, Anouck; D'HAESE, Sarah; HAMAD, Ibrahim; KLEINEWIETFELD, Markus; MEBIS, Jeroen; MULLENS, Wilfried; LAMBRICHTS, Ivo; WOLFS, Esther; DELUYKER, Dorien & BITO, Virginie (2024) Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity. In: Antioxidants, 13 (1) (Art N° 112). | - |
item.fulltext | With Fulltext | - |
item.contributor | HAESEN, Sibren | - |
item.contributor | JAGER, Manon Marie | - |
item.contributor | Brillouet, Aline | - |
item.contributor | DE LAAT, Iris | - |
item.contributor | VASTMANS, Lotte | - |
item.contributor | VERGHOTE, Eline | - |
item.contributor | DELAET, Anouck | - |
item.contributor | D'HAESE, Sarah | - |
item.contributor | HAMAD, Ibrahim | - |
item.contributor | KLEINEWIETFELD, Markus | - |
item.contributor | MEBIS, Jeroen | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | WOLFS, Esther | - |
item.contributor | DELUYKER, Dorien | - |
item.contributor | BITO, Virginie | - |
item.accessRights | Open Access | - |
crisitem.journal.eissn | 2076-3921 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Haesen et al. 2024 Antioxidants.pdf | Published version | 2.46 MB | Adobe PDF | View/Open |
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