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http://hdl.handle.net/1942/42337
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DC Field | Value | Language |
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dc.contributor.author | HEHL, Melina | - |
dc.contributor.author | VAN MALDEREN, Shanti | - |
dc.contributor.author | GERAERTS, Marc | - |
dc.contributor.author | MEESEN, Raf | - |
dc.contributor.author | Rothwell, John | - |
dc.contributor.author | SWINNEN, Stephan | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.date.accessioned | 2024-02-07T11:57:24Z | - |
dc.date.available | 2024-02-07T11:57:24Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-01-16T15:01:54Z | - |
dc.identifier.citation | CLINICAL NEUROPHYSIOLOGY, 158 , p. 180 -195 | - |
dc.identifier.issn | 1388-2457 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42337 | - |
dc.description.abstract | Objective: Using dual-site transcranial magnetic stimulation (dsTMS), the effective connectivity between the primary motor cortex (M1) and adjacent brain areas such as the dorsal premotor cortex (PMd) can be investigated. However, stimulating two brain regions in close proximity (e.g., ±2.3 cm for intrahemispheric PMd–M1) is subject to considerable spatial restrictions that potentially can be overcome by combining two standard figure-of-eight coils in a novel dsTMS setup. Methods: After a technical evaluation of its induced electric fields, the dsTMS setup was tested in vivo (n = 23) by applying a short-interval intracortical inhibition (SICI) protocol. Additionally, the intrahemispheric PMd–M1 interaction was probed. E-field modelling was performed using SimNIBS. Results: The technical evaluation yielded no major alterations of the induced electric fields due to coil overlap. In vivo, the setup reliably elicited SICI. Investigating intrahemispheric PMd–M1 interactions was feasible (inter-stimulus interval 6 ms), resulting in modulation of M1 output. Conclusions: The presented dsTMS setup provides a novel way to stimulate two adjacent brain regions with fewer technical and spatial limitations than previous attempts. Significance: This dsTMS setup enables more accurate and repeatable targeting of brain regions in close proximity and can facilitate innovation in the field of effective connectivity | - |
dc.description.sponsorship | This work was supported by the Research Fund KU Leuven (C16/15/070), the Research Foundation Flanders grant (G039821N), the Excellence of Science grant (EOS 30446199, MEMODYN) and the Hercules fund AUHL/11/01 (R-3987) and I005018N. Melina Hehl (11F6921N) and Shanti Van Malderen (11L9322N) are funded by a fellowship grant from Research Foundation Flanders. Shanti Van Malderen is also supported by the UHasselt Special Research Fund grant (BOF21INCENT15). The authors declare no competing financial interests. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.rights | 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. | - |
dc.subject.other | Transcranial magnetic stimulation (TMS) | - |
dc.subject.other | Dual-site TMS (dsTMS) | - |
dc.subject.other | Intrahemispheric interaction | - |
dc.subject.other | Dorsal premotor cortex (PMd) | - |
dc.subject.other | Effective functional connectivity | - |
dc.title | Probing intrahemispheric interactions with a novel dual-site TMS setup | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 195 | - |
dc.identifier.spage | 180 | - |
dc.identifier.volume | 158 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Cuypers, K (corresponding author), Hasselt Univ, Rehabil Res Inst REVAL, Neuroplast & Movement Control Res Grp, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | koen.cuypers@uhasselt.be | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.clinph.2023.12.128 | - |
dc.identifier.isi | 001166865900001 | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.identifier.eissn | 1872-8952 | - |
local.provider.type | Orcid | - |
local.description.affiliation | [Hehl, Melina; Van Malderen, Shanti; Meesen, Raf L. J.; Swinnen, Stephan P.; Cuypers, Koen] Katholieke Univ Leuven, Dept Movement Sci, Grp Biomed Sci, Movement Control & Neuroplast Res Grp, B-3001 Heverlee, Belgium. | - |
local.description.affiliation | [Hehl, Melina; Van Malderen, Shanti; Swinnen, Stephan P.; Cuypers, Koen] Katholieke Univ Leuven, Leuven Brain Inst LBI, Leuven, Belgium. | - |
local.description.affiliation | [Hehl, Melina; Van Malderen, Shanti; Geraerts, Marc; Meesen, Raf L. J.; Cuypers, Koen] Hasselt Univ, Rehabil Res Inst REVAL, Neuroplast & Movement Control Res Grp, Diepenbeek, Belgium. | - |
local.description.affiliation | [Rothwell, John C.] UCL, Sobell Dept Motor Neurosci & Movement Disorders, Inst Neurol, London, England. | - |
local.description.affiliation | [Cuypers, Koen] Hasselt Univ, Rehabil Res Inst REVAL, Neuroplast & Movement Control Res Grp, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | HEHL, Melina; VAN MALDEREN, Shanti; GERAERTS, Marc; MEESEN, Raf; Rothwell, John; SWINNEN, Stephan & CUYPERS, Koen (2024) Probing intrahemispheric interactions with a novel dual-site TMS setup. In: CLINICAL NEUROPHYSIOLOGY, 158 , p. 180 -195. | - |
item.accessRights | Embargoed Access | - |
item.contributor | HEHL, Melina | - |
item.contributor | VAN MALDEREN, Shanti | - |
item.contributor | GERAERTS, Marc | - |
item.contributor | MEESEN, Raf | - |
item.contributor | Rothwell, John | - |
item.contributor | SWINNEN, Stephan | - |
item.contributor | CUYPERS, Koen | - |
item.embargoEndDate | 2024-08-01 | - |
crisitem.journal.issn | 1388-2457 | - |
crisitem.journal.eissn | 1872-8952 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Intra_PMd-M1_2023_v7_accepted_version.pdf Until 2024-08-01 | Peer-reviewed author version | 3.01 MB | Adobe PDF | View/Open Request a copy |
1-s2.0-S1388245723009331-main.pdf Restricted Access | Published version | 3.87 MB | Adobe PDF | View/Open Request a copy |
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