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Title: | Unveiling mortality risk factors in paediatric sickle cell disease patients during acute crises in the Democratic Republic of the Congo | Authors: | Boma, Paul Muteb Ngimbi, Stéphanie Luntadila Kindundu, Junior Makiese Wela, Jean Israël Ngoie, Nathalie Lukanke Ngwamah, Valentin Mukeba Tshiswaka, Sandra Mbuyi Monga, Joséphine Kalenga Panda, Jules Mulefu BONNECHERE, Bruno |
Issue Date: | 2024 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | BLOOD CELLS MOLECULES AND DISEASES, 105 (Art N° 102828) | Abstract: | Sickle cell disease (SCD) is a significant health burden in the Democratic Republic of the Congo (DRC). This study aims to identify predictive factors of mortality in SCD children admitted to emergency care in Lubumbashi, DRC. We performed a non-interventional cohort follow-up on SCD patients aged 0 to 16 admitted for a “true emergency”. Demographic, clinical, and biological data were collected. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors associated with mortality. Among the 121 patients included, 24 died during the follow-up period. Univariate regression revealed age, Mikobi score, referral origin, stroke, and severe infection as significant risk factors. Multivariate analyses identified Hb, WBC, SR, and LDH as predictive factors of mortality. Notably, patients aged 12 to 16 years faced a higher risk, shifting the age of mortality from early to late childhood and adolescence. This study provides valuable insights into mortality risk factors for paediatric SCD patients during acute crises. Early diagnosis, regular follow-up, and therapeutic education are essential to improve patient outcomes and survival rates. These findings contribute to better disease management and targeted interventions, aiming to reduce mortality associated with SCD. | Notes: | Bonnechère, B (corresponding author), Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. | Keywords: | Sickle cell disease;Mortality;Assessment;DR Congo | Document URI: | http://hdl.handle.net/1942/42340 | ISSN: | 1079-9796 | e-ISSN: | 1096-0961 | DOI: | 10.1016/j.bcmd.2024.102828 | ISI #: | 001170992300001 | Rights: | 2024 ElsevierInc. Allrightsreserved | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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