Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/42342
Title: | Lipids in inflammasome activation and autoinflammatory disorders | Authors: | WOUTERS, Flore VAN DER HILST, Jeroen BOGIE, Jeroen |
Issue Date: | 2024 | Publisher: | MOSBY-ELSEVIER | Source: | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 153 (1) , p. 1 -11 | Abstract: | Autoinflammatory diseases (AIDs) are a group of rare monogenetic disorders characterized by recurrent episodes of fever and systemic inflammation. A major pathologic hallmark of AIDs is excessive inflammasome assembly and activation, often the result of gain-of-function mutations in genes encoding core inflammasome components, including pyrin and cryopyrin. Recent advances in lipidomics have revealed that dysregulated metabolism of lipids such as cholesterol and fatty acids, especially in innate immune cells, exerts complex effects on inflammasome activation and the pathogenesis of AIDs. In this review, we summarize and discuss the impact of lipids and their metabolism on inflammasome activation and the disease pathogenesis of the most common AIDs, including familial Mediterranean fever, cryopyrin-associated periodic syndromes, and mevalonate kinase deficiency. We postulate that lipids hold diagnostic value in AIDs and that dietary and pharmacologic intervention studies could represent a promising approach to attenuate inflammasome activation and AID progression. | Notes: | Bogie, J (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium.; Bogie, J (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Bldg C, B-3590 Diepenbeek, Belgium. jeroen.bogie@uhasselt.be |
Keywords: | Autoinflammation;inflammasome;innate immunity;lipids | Document URI: | http://hdl.handle.net/1942/42342 | ISSN: | 0091-6749 | e-ISSN: | 1097-6825 | DOI: | 10.1016/j.jaci.2023.10.008 | ISI #: | 001154528000001 | Datasets of the publication: | 10.1016/j.jaci.2023.10.008 | Rights: | 2023AmericanAcademyofAllergy,Asthma&Immunology | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0091674923013477-main.pdf Restricted Access | Published version | 1.04 MB | Adobe PDF | View/Open Request a copy |
Wouters et al 2023 (3).pdf | Peer-reviewed author version | 944.19 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.