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http://hdl.handle.net/1942/42396
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DC Field | Value | Language |
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dc.contributor.author | MOHTI, Hicham | - |
dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | DIERCKX, Tess | - |
dc.contributor.author | BOCKEN, Christel | - |
dc.contributor.author | Boeykens, Annick | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.contributor.author | Zaid, Abdelhamid | - |
dc.date.accessioned | 2024-02-13T09:52:58Z | - |
dc.date.available | 2024-02-13T09:52:58Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-02-13T07:21:47Z | - |
dc.identifier.citation | Journal of Herbal Medicine, 42 (Art N° 100813) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42396 | - |
dc.description.abstract | Introduction: Silene vulgaris (Moench) Garcke subsp. macrocarpa is a wild herbaceous plant known for its nutraceutical properties, and use in folk medicine. This study investigates the anti-cancer properties of S. vulgaris extracts.Methods: The leaves and roots of S. vulgaris were extracted by the Soxhlet extractor with ethanol, their phenolic content was determined by RTHPLC-DAD. By using squamous cell carcinoma cells and bone marrow-derived macrophages, we defined the ability of S. vulgaris extracts to kill tumour cells and suppress the tumour -promoting phenotype of macrophages.Results: A total of 21 phenolic compounds were detected, among which dihydrochalcones phloredzin and phloretin were most abundant, encompassing about 70% of the whole polyphenolic content in leaf extract. In the root extract, 45.75% of the polyphenolic compounds are flavonoids (epicatechin, epicatechin gallate, and avicularin). The leaf and the root extracts exhibit cytotoxic activity against A431 tumour cells. The highest cytotoxic activity was observed by root extract (IC50 =102.65 vs 173.26 mu g /mL). Interestingly, this extract also most potently induces the anti-tumour properties of BMDMs by decreasing the expression of genes typically expressed by tumour-associated macrophages, such as ARG1, CD163, CD209, TREM2, FIZZ1, MMP9, and CCL17, and suppressing the expression of the angiogenic factors EGF and VEGF. In contrast, the leaf extract promotes the expression of pro-inflammatory mediators IL-6, TNF-alpha, and iNOS in macrophages.Conclusions: The results highlight the anti-tumour properties of S. vulgaris leaves and roots, which underscore its effectiveness in traditional medicine and may open new avenues for its use in therapeutic anti-cancer applications. | - |
dc.description.sponsorship | This work was carried out within the program of the institutional cooperation (CUI-UMI-UHasselt), and financially supported by VLIRUOS. The authors gratefully thank Prof. Jalal el Oualidi for plant identification. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER GMBH | - |
dc.rights | 2023 Elsevier GmbH. All rights reserved. | - |
dc.subject.other | Silene vulgaris (Moench) Garcke subsp. macrocarpa (Moench) | - |
dc.subject.other | Phenolic composition | - |
dc.subject.other | Cytotoxic effect | - |
dc.subject.other | apoptosis induction | - |
dc.subject.other | Immunomodulatory effect | - |
dc.title | Inhibition of carcinoma cell growth and promotion of inflammatory properties of macrophages by Silene vulgaris (Moench) Garcke subsp. macrocarpa ethanolic extract | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 42 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mohti, H (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Biochem, B-3500 Hasselt, Belgium.; Mohti, H (corresponding author), Moulay Ismail Univ Meknes, Fac Sci, Management & Valorizat Nat Resources, Meknes, Morocco. | - |
dc.description.notes | hicham.mohti@uhasselt.be; jeroen.bogie@uhasselt.be; | - |
dc.description.notes | tess.dierckx@uhasselt.be; christel.bocken@uhasselt.be; | - |
dc.description.notes | annick.boeykens@odisee.be; jerome.hendriks@uhasselt.be; a.zaid@umi.ac.ma | - |
local.publisher.place | HACKERBRUCKE 6, 80335 MUNICH, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 100813 | - |
dc.identifier.doi | 10.1016/j.hermed.2023.100813 | - |
dc.identifier.isi | 001148230000001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mohti, Hicham; Bogie, Jeroen F. J.; Dierckx, Tess; Bocken, Christel; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Biochem, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Mohti, Hicham; Zaid, Abdelhamid] Moulay Ismail Univ Meknes, Fac Sci, Management & Valorizat Nat Resources, Meknes, Morocco. | - |
local.description.affiliation | [Boeykens, Annick] Odisee Univ Coll, Sch Technol, Dept Chem, B-9000 Ghent, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | MOHTI, Hicham; BOGIE, Jeroen; DIERCKX, Tess; BOCKEN, Christel; Boeykens, Annick; HENDRIKS, Jerome & Zaid, Abdelhamid (2023) Inhibition of carcinoma cell growth and promotion of inflammatory properties of macrophages by Silene vulgaris (Moench) Garcke subsp. macrocarpa ethanolic extract. In: Journal of Herbal Medicine, 42 (Art N° 100813). | - |
item.accessRights | Embargoed Access | - |
item.contributor | MOHTI, Hicham | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | DIERCKX, Tess | - |
item.contributor | BOCKEN, Christel | - |
item.contributor | Boeykens, Annick | - |
item.contributor | HENDRIKS, Jerome | - |
item.contributor | Zaid, Abdelhamid | - |
item.embargoEndDate | 2024-06-30 | - |
crisitem.journal.issn | 2210-8033 | - |
crisitem.journal.eissn | 2210-8041 | - |
Appears in Collections: | Research publications |
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1-s2.0-S2210803323001914-main.pdf Until 2024-06-30 | Peer-reviewed author version | 1.65 MB | Adobe PDF | View/Open Request a copy |
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