Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/42417
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dc.contributor.authorSANN, Sotheary-
dc.contributor.authorKLEINEWIETFELD, Markus-
dc.contributor.authorCantaert, Tineke-
dc.date.accessioned2024-02-14T09:26:43Z-
dc.date.available2024-02-14T09:26:43Z-
dc.date.issued2024-
dc.date.submitted2024-02-14T08:52:45Z-
dc.identifier.citationEmerging Microbes & Infections, 13 (1) (Art N° 2304061)-
dc.identifier.urihttp://hdl.handle.net/1942/42417-
dc.description.abstractMosquito-borne viral infections are on the rise worldwide and can lead to severe symptoms such as haemorrhage, encephalitis, arthritis or microcephaly. A protective immune response following mosquito-borne viral infections requires the generation of a controlled and balanced immune response leading to viral clearance without immunopathology. Here, regulatory T cells play a central role in restoring immune homeostasis. In current review, we aim to provide an overview and summary of the phenotypes of FOXP3+ Tregs in various mosquito-borne arboviral disease, their association with disease severity and their functional characteristics. Furthermore, we discuss the role of cytokines and Tregs in the immunopathogenesis of mosquito-borne infections. Lastly, we discuss possible novel lines of research which could provide additional insight into the role of Tregs in mosquito-borne viral infections in order to develop novel therapeutic approaches or vaccination strategies.-
dc.description.sponsorshipT.C. is funded by the Pasteur network, HHMI-Wellcome Trust International Research Scholar (208710/Z/17/Z) and NIH-PICREID (1U01AI151758). S.S. is supported by a Institut Pasteur du Cambodge PhD fellowship and a BOF/ BILA fellowship from the University of Hasselt. M.K. was supported by a SALK-grant from the government of Flanders, by an Odysseus-grant (Project ID G0G1216FWO) and senior research project (Project ID G080121N) of the FWO and by a BOF grant (ADMIRE, Project ID 21GP17BOF) from Hasselt University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS LTD-
dc.rights2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.-
dc.subject.otherArboviruses-
dc.subject.otherregulatory T cells-
dc.subject.otherdengue-
dc.subject.otherimmunopathology-
dc.subject.otherFOXP3-
dc.titleBalancing functions of regulatory T cells in mosquito-borne viral infections-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume13-
local.format.pages12-
local.bibliographicCitation.jcatA1-
dc.description.notesCantaert, T (corresponding author), Pasteur Network, Inst Pasteur Cambodge, Immunol Unit, Phnom Penh 12201, Cambodia.-
dc.description.notestcantaert@pasteur-kh.org-
local.publisher.place2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedReview-
local.bibliographicCitation.artnr2304061-
dc.identifier.doi10.1080/22221751.2024.2304061-
dc.identifier.pmid38192073-
dc.identifier.isi001148660100001-
local.provider.typewosris-
local.description.affiliation[Sann, Sotheary; Cantaert, Tineke] Pasteur Network, Inst Pasteur Cambodge, Immunol Unit, Phnom Penh 12201, Cambodia.-
local.description.affiliation[Sann, Sotheary; Kleinewietfeld, Markus] Hasselt Univ, Biomed Res Inst, Dept Immunol, Diepenbeek, Belgium.-
local.description.affiliation[Kleinewietfeld, Markus] Hasselt Univ, VIB Ctr Inflammat Res IRC, VIB Lab Translat Immunomodulat, Diepenbeek, Belgium.-
local.uhasselt.internationalyes-
item.fullcitationSANN, Sotheary; KLEINEWIETFELD, Markus & Cantaert, Tineke (2024) Balancing functions of regulatory T cells in mosquito-borne viral infections. In: Emerging Microbes & Infections, 13 (1) (Art N° 2304061).-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.contributorSANN, Sotheary-
item.contributorKLEINEWIETFELD, Markus-
item.contributorCantaert, Tineke-
crisitem.journal.eissn2222-1751-
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