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http://hdl.handle.net/1942/42523
Title: | Cancer therapy-related vaginal toxicity: its prevalence and assessment methods-a systematic review | Authors: | CLAES, Marithe Tuts, L. ROBIJNS, Jolien Mulders, K. van de Werf, E. BULENS, Paul MEBIS, Jeroen |
Issue Date: | 2024 | Publisher: | SPRINGER | Source: | Journal of Cancer Survivorship, | Status: | Early view | Abstract: | PurposeIn 2020, almost 9 million women were diagnosed with cancer worldwide. Despite advancements in cancer treatment strategies, patients still suffer from acute and long-term side effects. This systematic review aims to evaluate the most frequently reported adverse effects in the genitourinary system and compare them across cancer types, treatment modalities, and evaluation methods.MethodsPubmed Central, SCOPUS, and Cochrane Library were searched following the PRISMA guidelines to identify all prospective and retrospective observational cohort studies and randomized controlled trials assessing vaginal side effects of adult female cancer patients. The study quality was evaluated using The Newcastle-Ottawa Scale or the Risk of Bias 2 tool, as appropriate.ResultsThe most prevalent population was breast cancer patients, followed by gynaecological cancer patients. Overall, the focus was on vaginal dryness, while vaginal stenosis was the primary outcome in gynaecological cancer patients. Significant discrepancies were found in the frequency and severity of the reported adverse events. Most studies in this review evaluated side effects using patient-reported outcome measures (PROMs).ConclusionsGenitourinary syndrome of menopause following cancer treatment is most frequently documented in breast and gynaecological cancer patients, often focussing on vaginal dryness and vaginal stenosis based on PROMs. This review provides a complete overview of the literature, but more high-quality clinical trials are necessary to draw firm conclusions on acute and chronic vaginal toxicity following cancer treatment.Implications for cancer survivorsThis review could help improve the current preventive and curative management options for genitourinary complications, thereby increasing the patient's QoL and sexual functioning. | Notes: | Claes, M (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium.; Claes, M (corresponding author), LCRC, Hasselt, Belgium.; Claes, M (corresponding author), Jessa Hosp, Dept Med Oncol, Salvatorstr 20, B-3500 Hasselt, Belgium.; Claes, M (corresponding author), Jessa Hosp, Dept Jessa & Sci, Salvatorstr 20, B-3500 Hasselt, Belgium. marithe.claes@uhasselt.be |
Keywords: | Cancer treatment;Vaginal toxicity;Vaginal dryness;Vaginal stenosis;Quality of life;Sexual functioning | Document URI: | http://hdl.handle.net/1942/42523 | ISSN: | 1932-2259 | e-ISSN: | 1932-2267 | DOI: | 10.1007/s11764-024-01553-y | ISI #: | 001166437500001 | Rights: | The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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s11764-024-01553-y.pdf Restricted Access | Early view | 974.79 kB | Adobe PDF | View/Open Request a copy |
ACFrOgCkpVindgjuVtaOZ3erebHB5Pvjpk3lF8bbBedk9s.pdf | Peer-reviewed author version | 275.21 kB | Adobe PDF | View/Open |
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