Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/42551
Title: | Investigating the variability of prefrontal tDCS effects on working memory: An individual E-field distribution study | Authors: | Razza, Lais B. De Smet , Stefanie VAN HOORNWEDER, Sybren De Witte, Sara Luethi, Matthias S. Baeken, Chris Brunoni, Andre R. Vanderhasselt, Marie-Anne |
Issue Date: | 2024 | Publisher: | ELSEVIER MASSON, CORP OFF | Source: | CORTEX, 172 , p. 38 -48 | Abstract: | Transcranial direct current stimulation (tDCS) over the prefrontal cortex has the potential to enhance working memory by means of a weak direct current applied to the scalp. However, its effects are highly variable and possibly dependent on individual variability in cortical architecture and head anatomy. Unveiling sources of heterogeneity might improve fundamental and clinical application of tDCS in the field. Therefore, we investigated sources of tDCS variability of prefrontal 1.5 mA tDCS, 3 mA tDCS and sham tDCS in 40 participants (67.5% women, mean age 24.7 years) by associating simulated electric field (E-field) magnitude in brain regions of interest (dorsolateral prefrontal cortex, anterior cingulate cortex (ACC) and subgenual ACC) and working memory performance. Emotional and non-emotional 3-back paradigms were used. In the tDCS protocol analysis, effects were only significant for the 3 mA group, and only for the emotional tasks. In the individual E-field magnitude analysis, faster responses in non-emotional, but not in the emotional task, were associated with stronger E-fields in all brain regions of interest. Concluding, individual E-field distribution might explain part of the variability of pre-frontal tDCS effects on working memory performance and in clinical samples. Our results suggest that tDCS effects might be more consistent or improved by applying personalizing current intensity, although this hypothesis should be confirmed by further studies. (c) 2023 Elsevier Ltd. All rights reserved. | Notes: | Razza, LB (corresponding author), Univ Ghent, Ghent Univ Hosp, Dept Head & Skin Psychiat & Med Psychol, GHEPLab, 13K12 Entrance 12,Corneel Heymanslaan 10, B-9000 Ghent, Belgium. lais.razza@ugent.be |
Keywords: | Working memory;Prefrontal cortex;Transcranial direct current stimulation;Electric field;Interindividual variability | Document URI: | http://hdl.handle.net/1942/42551 | ISSN: | 0010-9452 | e-ISSN: | 1973-8102 | DOI: | 10.1016/j.cortex.2023.10.025 | ISI #: | 001165824900001 | Rights: | 2023 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Investigating the variability of prefrontal tDCS effects on working memory_ An individual E-field distribution study.pdf Restricted Access | Published version | 2.39 MB | Adobe PDF | View/Open Request a copy |
Cortex_D_AV.pdf | Peer-reviewed author version | 1.31 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.