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http://hdl.handle.net/1942/42627
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DC Field | Value | Language |
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dc.contributor.author | STULENS, Yannick | - |
dc.contributor.author | MUELLER, Brittany | - |
dc.contributor.author | VAN HOOF, Rebekka | - |
dc.contributor.author | Nelissen, Inge | - |
dc.contributor.author | WAGNER, Patrick | - |
dc.contributor.author | Kolpashchikov, Dmitry | - |
dc.contributor.author | HOOYBERGHS, Jef | - |
dc.date.accessioned | 2024-03-12T14:55:07Z | - |
dc.date.available | 2024-03-12T14:55:07Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-03-11T13:28:26Z | - |
dc.identifier.citation | - | |
dc.identifier.uri | http://hdl.handle.net/1942/42627 | - |
dc.description.abstract | Duplex formation via hybridization provides a detection technique where one of the strands is designed to match a mutant sequence and probe its presence. In a majority wild-type background consisting of single-nucleotide variations, the probe is however subject to cross-hybridization, lowering the detection sensitivity of low-abundant mutants. We use thermodynamics-based probe design and Langmuir theory to increase sensitivity and quantify the amount of mutant in a sample. | - |
dc.language.iso | en | - |
dc.subject.other | nucleic acid thermodynamics | - |
dc.subject.other | mutation detection | - |
dc.subject.other | Langmuir adsorption theory | - |
dc.title | Use of DNA thermodynamics for low-abundance mutation detection by DNA hybridization | - |
dc.type | Conference Material | - |
local.bibliographicCitation.jcat | C2 | - |
dc.relation.references | [1] S.K. Nomidis et al., Langmuir, 2019, doi: 10.1021/acs.langmuir.9b01761 [2] R. Van Hoof et al., Sensors and Actuators B: Chemical, 2022, doi: 10.1016/j.snb.2022.132175. [3] R.J. Karadeema et al., Nanoscale, 2018, doi: 10.1039/C8NR01107A. | - |
local.type.refereed | Non-Refereed | - |
local.type.specified | Conference Poster | - |
local.provider.type | - | |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | STULENS, Yannick; MUELLER, Brittany; VAN HOOF, Rebekka; Nelissen, Inge; WAGNER, Patrick; Kolpashchikov, Dmitry & HOOYBERGHS, Jef (2023) Use of DNA thermodynamics for low-abundance mutation detection by DNA hybridization. | - |
item.accessRights | Open Access | - |
item.contributor | STULENS, Yannick | - |
item.contributor | MUELLER, Brittany | - |
item.contributor | VAN HOOF, Rebekka | - |
item.contributor | Nelissen, Inge | - |
item.contributor | WAGNER, Patrick | - |
item.contributor | Kolpashchikov, Dmitry | - |
item.contributor | HOOYBERGHS, Jef | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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YannickStulens_EBS_Abstract.pdf | Conference material | 180.64 kB | Adobe PDF | View/Open |
YS_EBS2023.pdf | Conference material | 3.26 MB | Adobe PDF | View/Open |
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