Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/42643
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dc.contributor.authorMiyauchi, Hidetaka-
dc.contributor.authorGeisberger, Sabrina-
dc.contributor.authorLuft, Friedrich C.-
dc.contributor.authorWilck, Nicola-
dc.contributor.authorStegbauer, Johannes-
dc.contributor.authorWiig, Helge-
dc.contributor.authorDechend, Ralf-
dc.contributor.authorJantsch, Jonathan-
dc.contributor.authorKLEINEWIETFELD, Markus-
dc.contributor.authorKempa, Stefan-
dc.contributor.authorMueller, Dominik N.-
dc.date.accessioned2024-03-18T10:12:00Z-
dc.date.available2024-03-18T10:12:00Z-
dc.date.issued2024-
dc.date.submitted2024-03-18T08:50:04Z-
dc.identifier.citationHYPERTENSION, 81 (3) , p. 426 -435-
dc.identifier.urihttp://hdl.handle.net/1942/42643-
dc.description.abstractSalt sensitivity concerns blood pressure alterations after a change in salt intake (sodium chloride). The heart is a pump, and vessels are tubes; sodium can affect both. A high salt intake increases cardiac output, promotes vascular dysfunction and capillary rarefaction, and chronically leads to increased systemic vascular resistance. More recent findings suggest that sodium also acts as an important second messenger regulating energy metabolism and cellular functions. Besides endothelial cells and fibroblasts, sodium also affects innate and adaptive immunometabolism, immune cell function, and influences certain microbes and microbiota-derived metabolites. We propose the idea that the definition of salt sensitivity should be expanded beyond high blood pressure to cellular and molecular salt sensitivity.-
dc.description.sponsorshipH. Miyauchi is supported by a Postdoctoral Fellowship from the Alexander von Humboldt Foundation and Takeda Science Foundation, S. Geisberger by the Bundesministerium für Bildung und Forschung funding Multimodal Clinical Mass Spectrometry to Target Treatment Resistance (MSTARS), and D.N. Müller and N. Wilck by the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation; SFB 1470; Projektnummer 437531118 A06 and A10). D.N. Müller is supported by the Deutsches Zentrum für Herz-Kreislauf-Forschung (81Z0100110). N. Wilck and M. Kleinewietfeld are supported by the European Research Council under the European Union Horizon 2020 research and innovation program grant (852796, N. Wilck; 640116, M. Kleinewietfeld) and by the Corona Foundation in the German Stifter-Verband. J. Jantsch received funding from the DFG (JA1993/6-1) and DFG TRR 374 grant (project No. 509149993, TP B05). M. Kleinewietfeld was supported by a Strategisch Actieplan Limburg in het Kwadraat (SALK) grant from the government of Flanders and by an Odysseus grant of the Research Foundation Flanders, Belgium.-
dc.language.isoen-
dc.publisherLIPPINCOTT WILLIAMS & WILKINS-
dc.rights2023 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.-
dc.subject.othermacrophages-
dc.subject.othermitochondria-
dc.subject.othersalts-
dc.subject.othersodium-
dc.subject.otherT lymphocytes-
dc.titleSodium as an Important Regulator of Immunometabolism-
dc.typeJournal Contribution-
dc.identifier.epage435-
dc.identifier.issue3-
dc.identifier.spage426-
dc.identifier.volume81-
local.format.pages10-
local.bibliographicCitation.jcatA1-
dc.description.notesMüller, DN (corresponding author), Helmholtz Assoc, Max Delbruck Ctr Mol Med, Lindenberger Weg 80, D-13125 Berlin, Germany.-
local.publisher.placeTWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA-
local.type.refereedRefereed-
local.type.specifiedReview-
local.type.programmeH2020-
local.relation.h2020852796-
dc.identifier.doi10.1161/HYPERTENSIONAHA.123.19489-
dc.identifier.pmid37675565-
dc.identifier.isi001161867700026-
dc.contributor.orcidStegbauer, Johannes/0000-0001-8994-8102; Geisberger, Sabrina-
dc.contributor.orcidYasmin/0000-0001-6477-1312; Wiig, Helge/0000-0002-7740-8210; Luft,-
dc.contributor.orcidFriedrich/0000-0002-8635-1199; Kleinewietfeld,-
dc.contributor.orcidMarkus/0000-0002-2832-3149-
local.provider.typewosris-
local.description.affiliation[Miyauchi, Hidetaka; Geisberger, Sabrina; Luft, Friedrich C.; Wilck, Nicola; Dechend, Ralf; Kempa, Stefan; Mueller, Dominik N.] Helmholtz Assoc, Max Delbruck Ctr Mol Med, Lindenberger Weg 80, D-13125 Berlin, Germany.-
local.description.affiliation[Miyauchi, Hidetaka; Luft, Friedrich C.; Wilck, Nicola; Dechend, Ralf; Mueller, Dominik N.] Charite Univ Med Berlin, Berlin, Germany.-
local.description.affiliation[Miyauchi, Hidetaka; Luft, Friedrich C.; Wilck, Nicola; Dechend, Ralf; Mueller, Dominik N.] Free Univ Berlin, Berlin, Germany.-
local.description.affiliation[Miyauchi, Hidetaka; Luft, Friedrich C.; Wilck, Nicola; Dechend, Ralf; Mueller, Dominik N.] Humboldt Univ, Expt & Clin Res Ctr, Berlin, Germany.-
local.description.affiliation[Miyauchi, Hidetaka; Luft, Friedrich C.; Wilck, Nicola; Dechend, Ralf; Mueller, Dominik N.] Expt & Clin Res Ctr, Berlin, Germany.-
local.description.affiliation[Miyauchi, Hidetaka; Wilck, Nicola; Dechend, Ralf; Mueller, Dominik N.] German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.-
local.description.affiliation[Stegbauer, Johannes] Heinrich Heine Univ, Univ Hosp, Fac Med, Dept Nephrol, Dusseldorf, Germany.-
local.description.affiliation[Stegbauer, Johannes] Cardiovasc Res Inst Dusseldorf, Med Fac, CARID, Dusseldorf, Germany.-
local.description.affiliation[Stegbauer, Johannes] Univ Hosp, Dusseldorf, Germany.-
local.description.affiliation[Wiig, Helge] Univ Bergen, Dept Biomed, Bergen, Norway.-
local.description.affiliation[Dechend, Ralf] HELIOS Clin, Dept Cardiol & Nephrol, Berlin, Germany.-
local.description.affiliation[Jantsch, Jonathan] Univ Hosp Regensburg, Inst Clin Microbiol & Hyg, Regensburg, Germany.-
local.description.affiliation[Jantsch, Jonathan] Univ Regensburg, Regensburg, Germany.-
local.description.affiliation[Jantsch, Jonathan] Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany.-
local.description.affiliation[Jantsch, Jonathan] Univ Cologne, Univ Hosp Cologne, Ctr Mol Med Cologne, Cologne, Germany.-
local.description.affiliation[Jantsch, Jonathan] Univ Cologne, Fac Med, Cologne, Germany.-
local.description.affiliation[Kleinewietfeld, Markus] Hasselt Univ, VIB Lab Translat Immunomodulat, VIB Ctr Inflammat Res, Diepenbeek, Belgium.-
local.description.affiliation[Kleinewietfeld, Markus] Hasselt Univ, Biomed Res Inst, Dept Immunol, Diepenbeek, Belgium.-
local.description.affiliation[Kleinewietfeld, Markus] Hasselt Univ, Univ Multiple Sclerosis Ctr, Campus Diepenbeek, Diepenbeek, Belgium.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.fullcitationMiyauchi, Hidetaka; Geisberger, Sabrina; Luft, Friedrich C.; Wilck, Nicola; Stegbauer, Johannes; Wiig, Helge; Dechend, Ralf; Jantsch, Jonathan; KLEINEWIETFELD, Markus; Kempa, Stefan & Mueller, Dominik N. (2024) Sodium as an Important Regulator of Immunometabolism. In: HYPERTENSION, 81 (3) , p. 426 -435.-
item.accessRightsOpen Access-
item.contributorMiyauchi, Hidetaka-
item.contributorGeisberger, Sabrina-
item.contributorLuft, Friedrich C.-
item.contributorWilck, Nicola-
item.contributorStegbauer, Johannes-
item.contributorWiig, Helge-
item.contributorDechend, Ralf-
item.contributorJantsch, Jonathan-
item.contributorKLEINEWIETFELD, Markus-
item.contributorKempa, Stefan-
item.contributorMueller, Dominik N.-
crisitem.journal.issn0194-911X-
crisitem.journal.eissn1524-4563-
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