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Title: | Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study | Authors: | Delanote, Julie CORREA ROJO, Alejandro Wells, Philippa M. Steves, Claire J. Ertaylan, Goekhan |
Issue Date: | 2024 | Publisher: | NATURE PORTFOLIO | Source: | Scientific Reports, 14 (1) (Art N° 3626) | Abstract: | Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and eating disorders remain poorly understood. Currently, there are no robust biomarkers identified. We proposed a novel pyramid-layer design to accurately identify microbial/metabolomic signatures underlying mental disorders in the TwinsUK registry. Monozygotic and dizygotic twins discordant for mental disorders were screened, in a pairwise manner, for differentially abundant bacterial genera and circulating metabolites. In addition, multivariate analyses were performed, accounting for individual-level confounders. Our pyramid-layer study design allowed us to overcome the limitations of cross-sectional study designs with significant confounder effects and resulted in an association of the abundance of genus Parabacteroides with the diagnosis of mental disorders. Future research should explore the potential role of Parabacteroides as a mediator of mental health status. Our results indicate the potential role of the microbiome as a modifier in mental disorders that might contribute to the development of novel methodologies to assess personal risk and intervention strategies. | Notes: | Ertaylan, G (corresponding author), Flemish Inst Technol Res VITO, Sustainable Hlth, Mol, Belgium. gokhan.ertaylan@vito.be |
Keywords: | Humans;Cohort Studies;Cross-Sectional Studies;Gastrointestinal Microbiome;Mental Disorders;Microbiota | Document URI: | http://hdl.handle.net/1942/42650 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-024-53929-w | ISI #: | 001162143900053 | Rights: | The Author(s) 2024. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Systematic identification of the role of gut microbiota in mental disorders_ a TwinsUK cohort study.pdf | Published version | 2.55 MB | Adobe PDF | View/Open |
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