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http://hdl.handle.net/1942/42679
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DC Field | Value | Language |
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dc.contributor.author | Charleer, Sara | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | De Block, Christophe | - |
dc.contributor.author | Bolsens, Nancy | - |
dc.contributor.author | Nobels, Frank | - |
dc.contributor.author | Mikkelsen, Kristian | - |
dc.contributor.author | Mathieu, Chantal | - |
dc.contributor.author | Gillard, Pieter | - |
dc.date.accessioned | 2024-03-26T08:37:33Z | - |
dc.date.available | 2024-03-26T08:37:33Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-03-26T07:45:53Z | - |
dc.identifier.citation | Diabetes Technology & Therapeutics, | - |
dc.identifier.uri | http://hdl.handle.net/1942/42679 | - |
dc.description.abstract | Objectives: To study real-world effect of switching to Insulin Glargine 300 U/mL (Gla-300) on glucose metrics in people with type 1 diabetes. Methods: This retrospective secondary-use study compared 151 adults who switched to Gla-300 from first-generation long-acting insulins (Switchers) to 281 propensity-score matched controls (Non-switchers) who continued first-generation long-acting insulins. Primary endpoint was difference in time in range (TIR) evolution. A fictive "switching" date was assigned to Non-switchers to facilitate between-group comparisons. Results: In the period before switching, TIR decreased numerically for people in whom Gla-300 was eventually initiated (-0.05%/month [-0.16 to 0.07]), while it increased for matched controls (0.08%/month [0.02 to 0.015]; between-group difference P = 0.047). After Gla-300-initiation, Switchers had similar TIR increase compared to Non-switchers (P = 0.531). Switchers used higher basal dose than before switch (Delta 0.012 U/[kg center dot d] [0.006 to 0.018]; P < 0.0001). Conclusion: In real-life, Gla-300 was typically initiated in people where TIR was decreasing, which was reversed after switch using slightly higher basal insulin dose. | - |
dc.description.sponsorship | Sanofi | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject.other | Type 1 diabetes | - |
dc.subject.other | Continuous glucose monitoring | - |
dc.subject.other | Real life | - |
dc.subject.other | Long-acting insulin | - |
dc.title | Evaluation of Glucose Metrics in Adults with Type 1 Diabetes Switching to Insulin Glargine 300 U/mL: A Retrospective, Propensity-Score Matched Study | - |
dc.type | Journal Contribution | - |
local.format.pages | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Gillard, P (corresponding author), Univ Hosp Leuven, Dept Endocrinol, Herestr 49, B-3000 Leuven, Belgium. | - |
dc.description.notes | pieter.gillard@uzleuven.be | - |
local.publisher.place | 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1089/dia.2023.0371 | - |
dc.identifier.pmid | 38386438 | - |
dc.identifier.isi | 001180922400001 | - |
dc.contributor.orcid | Charleer, Sara/0000-0003-2100-4927; Mathieu, Chantal/0000-0002-4055-5233 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Charleer, Sara; Mathieu, Chantal; Gillard, Pieter] Univ Hosp Leuven KU Leuven, Dept Endocrinol, Leuven, Belgium. | - |
local.description.affiliation | [Fieuws, Steffen] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. | - |
local.description.affiliation | [Fieuws, Steffen] Univ Hasselt, Leuven, Belgium. | - |
local.description.affiliation | [De Block, Christophe; Bolsens, Nancy] Univ Antwerp, Univ Hosp Antwerp, Dept Endocrinol Diabetol Metab, Antwerp, Belgium. | - |
local.description.affiliation | [Nobels, Frank] OLV Hosp Aalst, Dept Endocrinol, Aalst, Belgium. | - |
local.description.affiliation | [Mikkelsen, Kristian] Sanofi Aventis Denmark AS, Copenhagen, Denmark. | - |
local.description.affiliation | [Gillard, Pieter] Fonds Wetenschappelijk Onderzoek FWO, Brussels, Belgium. | - |
local.description.affiliation | [Gillard, Pieter] Univ Hosp Leuven, Dept Endocrinol, Herestr 49, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Charleer, Sara; FIEUWS, Steffen; De Block, Christophe; Bolsens, Nancy; Nobels, Frank; Mikkelsen, Kristian; Mathieu, Chantal & Gillard, Pieter (2024) Evaluation of Glucose Metrics in Adults with Type 1 Diabetes Switching to Insulin Glargine 300 U/mL: A Retrospective, Propensity-Score Matched Study. In: Diabetes Technology & Therapeutics,. | - |
item.contributor | Charleer, Sara | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | De Block, Christophe | - |
item.contributor | Bolsens, Nancy | - |
item.contributor | Nobels, Frank | - |
item.contributor | Mikkelsen, Kristian | - |
item.contributor | Mathieu, Chantal | - |
item.contributor | Gillard, Pieter | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 1520-9156 | - |
crisitem.journal.eissn | 1557-8593 | - |
Appears in Collections: | Research publications |
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