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Title: | The DizzyQuest Combined with Accelerometry: Daily Physical Activities and Limitations among Patients with Bilateral Vestibulopathy Due to DFNA9 | Authors: | Martin, Erik de Hoon, Sofie Stultiens, Joost Janssen, Miranda Essers, Hans Meijer , Kenneth Bijnens , Wouter van de Berg, Maurice Herssens, Nolan JANSSENS DE VAREBEKE, Sebastien Hallemans, Ann Van Rompaey, Vincent Guinand, Nils Perez-Fornos, Angelica Widdershoven, Josine van de Berg, Raymond |
Issue Date: | 2024 | Publisher: | MDPI | Source: | Journal of Clinical Medicine, 13 (4) (Art N° 1131) | Abstract: | Background: DFNA9 is a genetic disease of the inner ear, causing progressive bilateral sensorineural deafness and bilateral vestibulopathy (BV). In this study, DizzyQuest, a mobile vestibular diary, and the MOX accelerometer were combined to assess the daily life functional limitations and physical activity of patients with DFNA9 suffering from BV. These parameters might be appropriate as potential candidacy criteria and outcome measures for new therapeutic interventions for BV. Methods: Fifteen DFNA9 patients with BV and twelve age-matched healthy controls were included. The DizzyQuest was applied for six consecutive days, which assessed the participants' extent of functional limitations, tiredness, types of activities performed during the day, and type of activity during which the participant felt most limited. The MOX accelerometer was worn during the same six days of DizzyQuest use, measuring the participants intensity and type of physical activity. Mixed-effects linear and logistic regression analyses were performed to compare the DFNA9 patients and control group. Results: DFNA9 patients with BV felt significantly more limited in activities during the day compared to the age-matched controls, especially in social participation (p < 0.005). However, these reported limitations did not cause adjustment in the types of activities and did not reduce the intensity or type of physical activity measured with accelerometry. In addition, no relationships were found between self-reported functional limitations and physical activity. Conclusions: This study demonstrated that self-reported functional limitations are significantly higher among DFNA9 patients with BV. As a result, these limitations might be considered as part of the candidacy criteria or outcome measures for therapeutic interventions. In addition, the intensity or type of physical activity performed during the day need to be addressed more specifically in future research. | Notes: | van de Berg, R (corresponding author), Maastricht Univ, Med Ctr, Dept Otorhinolaryngol & Head & Neck Surg, Div Balance Disorders, NL-6229 HX Maastricht, Netherlands. raymond.vande.berg@mumc.nl |
Keywords: | Dizzy;Quest;DFNA9;accelerometry | Document URI: | http://hdl.handle.net/1942/42743 | e-ISSN: | 2077-0383 | DOI: | 10.3390/jcm13041131 | ISI #: | 001175051100001 | Rights: | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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The DizzyQuest Combined with Accelerometry_ Daily Physical Activities and Limitations among Patients with Bilateral Vestibulopathy Due to DFNA9.pdf | Published version | 2.54 MB | Adobe PDF | View/Open |
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