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http://hdl.handle.net/1942/42823
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DC Field | Value | Language |
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dc.contributor.author | Pype, Lobke L. | - |
dc.contributor.author | BERTRAND, Philippe | - |
dc.contributor.author | Debonnaire, Philippe | - |
dc.contributor.author | DHONT, Sebastiaan | - |
dc.contributor.author | Hoekman, Boukje | - |
dc.contributor.author | Paelinck, Bernard P. | - |
dc.contributor.author | De Bock , Dina | - |
dc.contributor.author | HEIDBUCHEL, Hein | - |
dc.contributor.author | Van Craenenbroeck, Emeline M. | - |
dc.contributor.author | Van De Heyning, Caroline M. | - |
dc.date.accessioned | 2024-04-26T08:12:33Z | - |
dc.date.available | 2024-04-26T08:12:33Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-04-23T11:42:04Z | - |
dc.identifier.citation | Journal of Cardiovascular Development and Disease, 11 (3) (Art N° 71) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42823 | - |
dc.description.abstract | Surgical correction of severe mitral regurgitation (MR) can reverse left ventricular (LV) remodeling in patients with mitral valve prolapse (MVP). However, whether this process is similar to the case in Barlow's Disease (BD) and Fibro-elastic Deficiency (FED) is currently unknown. The aim of this study is to evaluate post-operative LV reverse remodeling and function in patients with BD versus FED. In this study, 100 MVP patients (BD = 37 and FED = 63) with severe MR who underwent mitral valve surgery at three Belgian centers were retrospectively included. Transthoracic echocardiography was used to assess MR severity, LV volumes and function before surgery and 6 months thereafter. Baseline MR severity, LV ejection fraction (LVEF), indexed LV end-diastolic (LVEDVi) and end-systolic volumes (LVESVi) were not different between the groups. After a median follow-up of 278 days, there was a similar decrease in LVEDVi, but a trend towards a smaller decrease in LVESVi in BD compared to FED (-3.0 +/- 11.2 mL/m(2) vs. -5.3 +/- 9.0 mL/m(2); p = 0.154). This resulted in a significantly larger decrease in LVEF in BD (-8.3 +/- 9.6%) versus FED (-3.9 +/- 6.9%) after adjusting for baseline LVEF (p < 0.001) and type of surgical intervention (p = 0.01). These findings suggest that LV (reverse) remodeling in BD could be affected by other mechanisms beyond volume overload, potentially involving concomitant cardiomyopathy. | - |
dc.description.sponsorship | This research received no external funding | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | mitral valve prolapse | - |
dc.subject.other | mitral regurgitation | - |
dc.subject.other | mitral valve annuloplasty | - |
dc.subject.other | mitral valve replacement | - |
dc.subject.other | left ventricular remodeling | - |
dc.title | Mitral Valve Surgery for Mitral Regurgitation Results in Reduced Left Ventricular Ejection Fraction in Barlow's Disease as Compared with Fibro-Elastic Deficiency | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 3 | - |
dc.identifier.volume | 11 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | van de Heyning, CM (corresponding author), Antwerp Univ Hosp, Dept Cardiol, B-2650 Edegem, Belgium.; van de Heyning, CM (corresponding author), Univ Antwerp, GENCOR Res Grp, B-2000 Antwerp, Belgium. | - |
dc.description.notes | lobke.pype@uza.be; caroline.vandeheyning@uza.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 71 | - |
dc.identifier.doi | 10.3390/jcdd11030071 | - |
dc.identifier.pmid | 38535094 | - |
dc.identifier.isi | 001193520100001 | - |
dc.contributor.orcid | Van De Heyning, Caroline M./0000-0002-4661-4732 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Pype, Lobke L.; Heidbuchel, Hein; Van Craenenbroeck, Emeline M.; Van De Heyning, Caroline M.] Antwerp Univ Hosp, Dept Cardiol, B-2650 Edegem, Belgium. | - |
local.description.affiliation | [Pype, Lobke L.; Paelinck, Bernard P.; Heidbuchel, Hein; Van Craenenbroeck, Emeline M.; Van De Heyning, Caroline M.] Univ Antwerp, GENCOR Res Grp, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Bertrand, Philippe B.; Dhont, Sebastiaan] Hosp Oost Limburg, Dept Cardiol, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Bertrand, Philippe B.; Dhont, Sebastiaan] Hasselt Univ, Fac Med & Life Sci, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Debonnaire, Philippe; Hoekman, Boukje] Sint Jan Hosp Bruges, Dept Cardiol, B-8000 Brugge, Belgium. | - |
local.description.affiliation | [Paelinck, Bernard P.; De Bock, Dina] Antwerp Univ Hosp, Dept Cardiac Surg, B-2650 Edegem, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.contributor | Pype, Lobke L. | - |
item.contributor | BERTRAND, Philippe | - |
item.contributor | Debonnaire, Philippe | - |
item.contributor | DHONT, Sebastiaan | - |
item.contributor | Hoekman, Boukje | - |
item.contributor | Paelinck, Bernard P. | - |
item.contributor | De Bock , Dina | - |
item.contributor | HEIDBUCHEL, Hein | - |
item.contributor | Van Craenenbroeck, Emeline M. | - |
item.contributor | Van De Heyning, Caroline M. | - |
item.fullcitation | Pype, Lobke L.; BERTRAND, Philippe; Debonnaire, Philippe; DHONT, Sebastiaan; Hoekman, Boukje; Paelinck, Bernard P.; De Bock , Dina; HEIDBUCHEL, Hein; Van Craenenbroeck, Emeline M. & Van De Heyning, Caroline M. (2024) Mitral Valve Surgery for Mitral Regurgitation Results in Reduced Left Ventricular Ejection Fraction in Barlow's Disease as Compared with Fibro-Elastic Deficiency. In: Journal of Cardiovascular Development and Disease, 11 (3) (Art N° 71). | - |
item.accessRights | Open Access | - |
crisitem.journal.eissn | 2308-3425 | - |
Appears in Collections: | Research publications |
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