Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/42934
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sardella, Gennaro | - |
dc.contributor.author | Spirito, Alessandro | - |
dc.contributor.author | Sartori, Samantha | - |
dc.contributor.author | Angiolillo, Dominick J. | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Hernandez, Jose M. De la Torre | - |
dc.contributor.author | Krucoff, Mitchell W. | - |
dc.contributor.author | Bangalore, Sripal | - |
dc.contributor.author | Bhatt, Deepak L. | - |
dc.contributor.author | Campo, Gianluca | - |
dc.contributor.author | Cao, Davide | - |
dc.contributor.author | Chehab, Bassem M. | - |
dc.contributor.author | Choi, James W. | - |
dc.contributor.author | Feng, Yihan | - |
dc.contributor.author | Ge, Junbo | - |
dc.contributor.author | Godfrey, Katherine | - |
dc.contributor.author | Hermiller, James | - |
dc.contributor.author | Kunadian, Vijay | - |
dc.contributor.author | Makkar, Raj R. | - |
dc.contributor.author | Maksoud, Aziz | - |
dc.contributor.author | Neumann, Franz-Josef | - |
dc.contributor.author | Picon, Hector | - |
dc.contributor.author | Saito, Shigeru | - |
dc.contributor.author | Thiele, Holger | - |
dc.contributor.author | Toelg, Ralph | - |
dc.contributor.author | Varenne, Olivier | - |
dc.contributor.author | Vogel, Birgit | - |
dc.contributor.author | Zhou, Yujie | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Mehran, Roxana | - |
dc.date.accessioned | 2024-05-14T12:13:30Z | - |
dc.date.available | 2024-05-14T12:13:30Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-05-13T13:13:03Z | - |
dc.identifier.citation | AMERICAN JOURNAL OF CARDIOLOGY, 214 , p. 94 -104 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42934 | - |
dc.description.abstract | This analysis aimed to evaluate the effect of 1- versus 3-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in older patients. Data from 3 prospective, single -arm studies (XIENCE Short DAPT Program), including patients with high bleeding risk successfully treated with an everolimus-eluting stent (XIENCE, Abbott) were analyzed. DAPT was discontinued at 1 or at 3 months in patients free from ischemic events and adherent to DAPT. Patients were stratified according to age (>= 75 and <75 years). The primary end point was all-cause death or myocardial infarction (MI). The key secondary end point was Bleeding Academic Research Consortium type 2 to 5 bleeding. The outcomes were assessed from 1 to 12 months after index PCI. Of 3,364 patients, 2,241 (66.6%) were aged >= 75 years. The risk of death or MI was similar with 1- versus 3month DAPT in patients aged >= 75 (8.5% vs 8.0%, adjusted hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.69 to 1.30) and <75 years (6.9% vs 7.8%, adjusted HR 0.97, 95% CI 0.60 to 1.57, interaction p = 0.478). Bleeding Academic Research Consortium type 2 to 5 bleeding was consistently lower with 1- than with 3-month DAPT in patients aged >= 75 years (7.2% vs 9.4%, adjusted HR 0.66, 95% CI 0.48 to 0.91) and <75 years (9.7% vs 11.9%, adjusted HR 0.86, 95% CI 0.57 to 1.29, interaction p = 0.737). In conclusion, in patients at high bleeding risk who underwent PCI, patients older and younger than 75 years derived a consistent benefit from 1- compared with 3-month DAPT in terms of bleeding reduction, with no increase in all-cause death or MI at 1 year. (c) 2024 Elsevier Inc. All rights reserved. | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.subject.other | percutaneous coronary intervention | - |
dc.subject.other | high bleeding risk | - |
dc.subject.other | elderly | - |
dc.subject.other | dual antiplatelet therapy | - |
dc.title | 1-Versus 3-Month DAPT in Older Patients at a High Bleeding Risk Undergoing PCI: Insights from the XIENCE Short DAPT Global Program | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 104 | - |
dc.identifier.spage | 94 | - |
dc.identifier.volume | 214 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mehran, R (corresponding author), Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA. | - |
dc.description.notes | Roxana.mehran@mountsinai.org | - |
local.publisher.place | 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.amjcard.2023.12.049 | - |
dc.identifier.pmid | 38185438 | - |
dc.identifier.isi | 001195263700001 | - |
dc.contributor.orcid | Windecker, Stephan/0000-0003-2653-6762 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Sardella, Gennaro] Policlin Umberto I Roma, Rome, Italy. | - |
local.description.affiliation | [Spirito, Alessandro; Sartori, Samantha; Cao, Davide; Feng, Yihan; Godfrey, Katherine; Vogel, Birgit; Mehran, Roxana] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA. | - |
local.description.affiliation | [Angiolillo, Dominick J.] Univ Florida, Coll Med, Div Cardiol, Jacksonville, FL USA. | - |
local.description.affiliation | [Vranckx, Pascal] Jessa Ziekenhuis, Dept Cardiol & Crit Care Med, Hasselt, Belgium. | - |
local.description.affiliation | [Hernandez, Jose M. De la Torre] Hosp Univ Marques de Valdecilla, IDIVAL, Santander, Spain. | - |
local.description.affiliation | [Hernandez, Jose M. De la Torre] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Krucoff, Mitchell W.] Duke Univ, Med Ctr, Div Cardiol, Durham, NC USA. | - |
local.description.affiliation | [Krucoff, Mitchell W.] Duke Clin Res Inst, Durham, NC USA. | - |
local.description.affiliation | [Bangalore, Sripal] NYU, Grossman Sch Med, New York, NY USA. | - |
local.description.affiliation | [Bhatt, Deepak L.] Icahn Sch Med Mt Sinai Hlth Syst, Mt Sinai Heart, New York, NY USA. | - |
local.description.affiliation | [Campo, Gianluca] Azienda Osped Univ Ferrara, Cardiol Unit, Cona, FE, Italy. | - |
local.description.affiliation | [Cao, Davide] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy. | - |
local.description.affiliation | [Chehab, Bassem M.] Ascens Via Christi Hosp, Cardiovasc Res Inst Kansas, Wichita, KS USA. | - |
local.description.affiliation | [Choi, James W.] Texas Hlth Presbyterian Hosp, Dallas, TX USA. | - |
local.description.affiliation | [Ge, Junbo] Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China. | - |
local.description.affiliation | [Hermiller, James] St Vincent Heart Ctr Indiana, Indianapolis, IN USA. | - |
local.description.affiliation | [Kunadian, Vijay] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Northumberland, England. | - |
local.description.affiliation | [Kunadian, Vijay] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Cardiothorac Ctr, Newcastle Upon Tyne, Northumberland, England. | - |
local.description.affiliation | [Makkar, Raj R.] Cedars Sinai Med Ctr, Smidt Heart Inst, Los Angeles, CA USA. | - |
local.description.affiliation | [Maksoud, Aziz] Kansas Heart Hosp, Wichita, KS USA. | - |
local.description.affiliation | [Maksoud, Aziz] Univ Kansas, Sch Med, Wichita, KS USA. | - |
local.description.affiliation | [Neumann, Franz-Josef] Univ Freiburg, Med Ctr, Univ Heart Ctr Freiburg Bad Krozingen, Dept Cardiol & Angiol, Freiburg, Germany. | - |
local.description.affiliation | [Picon, Hector] Redmond Reg Med Ctr, Rome, GA USA. | - |
local.description.affiliation | [Saito, Shigeru] Shonan Kamakura Gen Hosp, Kamakura, Kanagawa, Japan. | - |
local.description.affiliation | [Thiele, Holger] Univ Leipzig, Heart Ctr Leipzig, Leipzig, Germany. | - |
local.description.affiliation | [Thiele, Holger] Leipzig Heart Sci, Leipzig, Germany. | - |
local.description.affiliation | [Toelg, Ralph] Segeberger Kliniken GmbH, Herzzentrum, Bad Segeberg, Germany. | - |
local.description.affiliation | [Varenne, Olivier] Univ Paris Cite, Hop Cochin, AP HP, Paris, France. | - |
local.description.affiliation | [Zhou, Yujie] Beijing Anzhen Hosp, Beijing, Peoples R China. | - |
local.description.affiliation | [Valgimigli, Marco] Cardioctr Ticino Institue, Cardioctr Ticino Inst, Lugano, Switzerland. | - |
local.description.affiliation | [Valgimigli, Marco] Bern Univ Hosp, Bern, Switzerland. | - |
local.description.affiliation | [Windecker, Stephan] Bern Univ Hosp, Univ Bern, Dept Cardiol, Bern, Switzerland. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Embargoed Access | - |
item.embargoEndDate | 2024-09-01 | - |
item.fullcitation | Sardella, Gennaro; Spirito, Alessandro; Sartori, Samantha; Angiolillo, Dominick J.; VRANCKX, Pascal; Hernandez, Jose M. De la Torre; Krucoff, Mitchell W.; Bangalore, Sripal; Bhatt, Deepak L.; Campo, Gianluca; Cao, Davide; Chehab, Bassem M.; Choi, James W.; Feng, Yihan; Ge, Junbo; Godfrey, Katherine; Hermiller, James; Kunadian, Vijay; Makkar, Raj R.; Maksoud, Aziz; Neumann, Franz-Josef; Picon, Hector; Saito, Shigeru; Thiele, Holger; Toelg, Ralph; Varenne, Olivier; Vogel, Birgit; Zhou, Yujie; Valgimigli, Marco; Windecker, Stephan & Mehran, Roxana (2024) 1-Versus 3-Month DAPT in Older Patients at a High Bleeding Risk Undergoing PCI: Insights from the XIENCE Short DAPT Global Program. In: AMERICAN JOURNAL OF CARDIOLOGY, 214 , p. 94 -104. | - |
item.contributor | Sardella, Gennaro | - |
item.contributor | Spirito, Alessandro | - |
item.contributor | Sartori, Samantha | - |
item.contributor | Angiolillo, Dominick J. | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Hernandez, Jose M. De la Torre | - |
item.contributor | Krucoff, Mitchell W. | - |
item.contributor | Bangalore, Sripal | - |
item.contributor | Bhatt, Deepak L. | - |
item.contributor | Campo, Gianluca | - |
item.contributor | Cao, Davide | - |
item.contributor | Chehab, Bassem M. | - |
item.contributor | Choi, James W. | - |
item.contributor | Feng, Yihan | - |
item.contributor | Ge, Junbo | - |
item.contributor | Godfrey, Katherine | - |
item.contributor | Hermiller, James | - |
item.contributor | Kunadian, Vijay | - |
item.contributor | Makkar, Raj R. | - |
item.contributor | Maksoud, Aziz | - |
item.contributor | Neumann, Franz-Josef | - |
item.contributor | Picon, Hector | - |
item.contributor | Saito, Shigeru | - |
item.contributor | Thiele, Holger | - |
item.contributor | Toelg, Ralph | - |
item.contributor | Varenne, Olivier | - |
item.contributor | Vogel, Birgit | - |
item.contributor | Zhou, Yujie | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Mehran, Roxana | - |
crisitem.journal.issn | 0002-9149 | - |
crisitem.journal.eissn | 1879-1913 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1- Versus 3-Month DAPT in Older Patients at a High Bleeding Risk Undergoing .pdf Restricted Access | Published version | 1.37 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf Until 2024-09-01 | Peer-reviewed author version | 1.47 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.