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http://hdl.handle.net/1942/42942
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DC Field | Value | Language |
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dc.contributor.author | Derelle, Romain | - |
dc.contributor.author | VERDONCK, Rik | - |
dc.contributor.author | Jacob, Staffan | - |
dc.contributor.author | Huet, Michele | - |
dc.contributor.author | Akerman, Ildem | - |
dc.contributor.author | Philippe, Herve | - |
dc.contributor.author | Legrand, Delphine | - |
dc.date.accessioned | 2024-05-14T13:31:33Z | - |
dc.date.available | 2024-05-14T13:31:33Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-05-14T12:43:42Z | - |
dc.identifier.citation | Microbial Genomics, 10 (1) (Art N° 001175) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42942 | - |
dc.description.abstract | The extent of intraspecific genomic variation is key to understanding species evolutionary history, including recent adaptive shifts. Intraspecific genomic variation remains poorly explored in eukaryotic micro- organisms, especially in the nuclear dimorphic ciliates, despite their fundamental role as laboratory model systems and their ecological importance in many ecosystems. We sequenced the macronuclear genome of 22 laboratory strains of the oligohymenophoran Tetrahymena thermophila, a model species in both cellular biology and evolutionary ecology. We explored polymorphisms at the junctions of programmed eliminated sequences, and reveal their utility to barcode very closely related cells. As for other species of the genus Tetrahymena, we confirm micronuclear centromeres as gene diversification centres in T. thermophila, but also reveal a two- speed evolution in these regions. In the rest of the genome, we highlight recent diversification of genes coding for extracellular proteins and cell adhesion. We discuss all these findings in relation to this ciliate's ecology and cellular characteristics. | - |
dc.description.sponsorship | Funding information This work is part of the Agence Nationale de la Recherche (ANR) project POLLUCLIM (ANR-19-CE02-0021-01) attributed to D.L. that employed R.D. This work is part of TULIP (Laboratory of Excellence grant no. ANR-10 LABX-41), and was financially supported by a senior package attributed to H.P. that employed R.V. Acknowledgements We thank Nicolas Schtickzelle for having provided the strains used in this study and for fruitful interactions about unpublished genetic datasets he obtained in his lab. We also thank Léonard Dupont for his help in Python programming. | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGY SOC | - |
dc.rights | 2024 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. | - |
dc.subject.other | centromere evolution | - |
dc.subject.other | ciliate genomics | - |
dc.subject.other | macronuclear polymorphism | - |
dc.subject.other | programmed DNA elimination | - |
dc.title | The macronuclear genomic landscape within Tetrahymena thermophila | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 10 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Legrand, D (corresponding author), CNRS, Stn Ecol Theor & Expt, UAR2029, Moulis, France. | - |
dc.description.notes | delphine.legrand@sete.cnrs.fr | - |
local.publisher.place | 14-16 MEREDITH ST, LONDON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 001175 | - |
dc.identifier.doi | 10.1099/mgen.0.001175 | - |
dc.identifier.pmid | 38206129 | - |
dc.identifier.isi | 001200487000003 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Derelle, Romain; Verdonck, Rik; Jacob, Staffan; Huet, Michele; Philippe, Herve; Legrand, Delphine] CNRS, Stn Ecol Theor & Expt, UAR2029, Moulis, France. | - |
local.description.affiliation | [Akerman, Ildem] Univ Birmingham, Inst Metab & Syst Res, Birmingham, England. | - |
local.description.affiliation | [Derelle, Romain] Imperial Coll London, NIHR Hlth Protect Res Unit Resp Infect, Natl Heart & Lung Inst, London, England. | - |
local.description.affiliation | [Verdonck, Rik] Hasselt Univ, Ctr Environm Sci, Environm Biol, Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Derelle, Romain; VERDONCK, Rik; Jacob, Staffan; Huet, Michele; Akerman, Ildem; Philippe, Herve & Legrand, Delphine (2024) The macronuclear genomic landscape within Tetrahymena thermophila. In: Microbial Genomics, 10 (1) (Art N° 001175). | - |
item.contributor | Derelle, Romain | - |
item.contributor | VERDONCK, Rik | - |
item.contributor | Jacob, Staffan | - |
item.contributor | Huet, Michele | - |
item.contributor | Akerman, Ildem | - |
item.contributor | Philippe, Herve | - |
item.contributor | Legrand, Delphine | - |
crisitem.journal.issn | 2057-5858 | - |
crisitem.journal.eissn | 2057-5858 | - |
Appears in Collections: | Research publications |
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