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http://hdl.handle.net/1942/42966
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DC Field | Value | Language |
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dc.contributor.author | De Baetselier, Irith | - |
dc.contributor.author | Smet, Hilde | - |
dc.contributor.author | Kehoe, Kaat | - |
dc.contributor.author | Loosen, Imelda | - |
dc.contributor.author | Reynders , Marijke | - |
dc.contributor.author | Mansoor, Iqbal | - |
dc.contributor.author | Filippin, Lorenzo | - |
dc.contributor.author | Cauchie, Mathieu | - |
dc.contributor.author | Van Even, Ellen | - |
dc.contributor.author | Makki, Nadia | - |
dc.contributor.author | Schiettekatte, Gilberte | - |
dc.contributor.author | Vandewal, Wouter | - |
dc.contributor.author | Glibert, Bart | - |
dc.contributor.author | Matheeussen, Veerle | - |
dc.contributor.author | Beken, Yolien Van der | - |
dc.contributor.author | Cartuyvels, Reinoud | - |
dc.contributor.author | Steyaert, Sophia | - |
dc.contributor.author | Lemmens, Ann | - |
dc.contributor.author | Garrino, Maria-Grazia | - |
dc.contributor.author | Paridaens, Henry | - |
dc.contributor.author | Lazarova, Elena | - |
dc.contributor.author | Lissoir, Benedicte | - |
dc.contributor.author | Deffontaine, Marine | - |
dc.contributor.author | Heinrichs, Amelie | - |
dc.contributor.author | Saegeman, Veroniek | - |
dc.contributor.author | PADALKO, Elizaveta | - |
dc.contributor.author | Lecompte, Amaryl | - |
dc.contributor.author | Vanden Berghe, Wim | - |
dc.contributor.author | Kenyon, Chris | - |
dc.contributor.author | Van den Bossche , Dorien | - |
dc.date.accessioned | 2024-05-15T12:52:17Z | - |
dc.date.available | 2024-05-15T12:52:17Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-05-15T09:21:28Z | - |
dc.identifier.citation | Eurosurveillance, 29 (7) (Art N° 2300318) | - |
dc.identifier.issn | 1560-7917 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42966 | - |
dc.description.abstract | Background: Antimicrobial resistance (AMR) of Mycoplasma genitalium (MG) is a growing concern worldwide and surveillance is needed. In Belgium, samples are sent to the National Reference Centre of Sexually Transmitted Infections (NRC-STI) on a voluntary basis and representative or robust national AMR data are lacking. Aim: We aimed to estimate the occurrence of resistant MG in Belgium. Methods: Between July and November 2022, frozen remnants of MG -positive samples from 21 Belgian laboratories were analysed at the NRC-STI. Macrolide and fluoroquinolone resistance -associated mutations (RAMs) were assessed using Sanger sequencing of the 23SrRNA and parC gene. Differences in resistance patterns were correlated with surveillance methodology, sociodemographic and behavioural variables via Fisher's exact test and logistic regression analysis. Results: Of the 244 MG -positive samples received, 232 could be sequenced for macrolide and fluoroquinolone RAMs. Over half of the sequenced samples (55.2%) were resistant to macrolides. All sequenced samples from men who have sex with men (MSM) (24/24) were macrolide-resistant. Fluoroquinolone RAMs were found in 25.9% of the samples and occurrence did not differ between socio-demographic and sexual behaviour characteristics. Conclusion: Although limited in sample size, our data suggest no additional benefit of testing MG retrieved from MSM for macrolide resistance in Belgium, when making treatment decisions. The lower occurrence of macrolide resistance in other population groups, combined with emergence of fluoroquinolone RAMs support macrolide-resistance testing in these groups. Continued surveillance of resistance in MG in different population groups will be crucial to confirm our findings and to guide national testing and treatment strategies. | - |
dc.description.sponsorship | Funding The prospective study was financed by the Belgian government. Acknowledgements We would like to thank all laboratory personnel and physicians involved in the study. Moreover, we would like to specifically thank the personnel of the National Reference Centre of Sexually Transmitted Infections. And thank you Yaan Huguenay for the figure of Belgium. This work was published as a preprint article on medRxiv (De Baetselier I, Smet H, Kehoe K, Loosen I, Reynders M, Mansoor I, et al. Estimation of the real magnitude of antimicrobial resistance of Mycoplasma genitalium in Belgium by implementing a prospective surveillance programme. medRxiv 2023 June 6). | - |
dc.language.iso | en | - |
dc.publisher | EUR CENTRE DIS PREVENTION & CONTROL | - |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. | - |
dc.subject.other | Belgium | - |
dc.subject.other | Europe | - |
dc.subject.other | Mycoplasma genitalium | - |
dc.subject.other | antimicrobial resistance | - |
dc.subject.other | fluoroquinolone resistance | - |
dc.subject.other | macrolide resistance | - |
dc.subject.other | Male | - |
dc.subject.other | Humans | - |
dc.subject.other | Anti-Bacterial Agents | - |
dc.subject.other | Homosexuality, Male | - |
dc.subject.other | Macrolides | - |
dc.subject.other | Drug Resistance, Bacterial | - |
dc.subject.other | Mutation | - |
dc.subject.other | RNA, Ribosomal, 23S | - |
dc.subject.other | Fluoroquinolones | - |
dc.subject.other | Mycoplasma Infections | - |
dc.subject.other | Sexual and Gender Minorities | - |
dc.subject.other | Sexually Transmitted Diseases | - |
dc.title | Estimation of antimicrobial resistance of Mycoplasma genitalium, Belgium, 2022 | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 7 | - |
dc.identifier.volume | 29 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | De Baetselier, I (corresponding author), Inst Trop Med, Natl Reference Ctr Sexually Transmitted Infect Bel, Dept Clin Sci, Antwerp, Belgium. | - |
dc.description.notes | idebaetselier@itg.be | - |
local.publisher.place | TOMTEBODAVAGEN 11A, STOCKHOLM, 171 83, SWEDEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2300318 | - |
dc.identifier.doi | 10.2807/1560-7917.ES.2024.29.7.2300318 | - |
dc.identifier.pmid | 38362626 | - |
dc.identifier.isi | 001198714100003 | - |
dc.contributor.orcid | Matheeussen, Veerle/0000-0003-2137-2068 | - |
dc.identifier.eissn | 1560-7917 | - |
local.provider.type | wosris | - |
local.description.affiliation | [De Baetselier, Irith; Smet, Hilde; Van den Bossche, Dorien] Inst Trop Med, Natl Reference Ctr Sexually Transmitted Infect Bel, Dept Clin Sci, Antwerp, Belgium. | - |
local.description.affiliation | [Kehoe, Kaat; Makki, Nadia] Algemeen Med Lab, Antwerp, Belgium. | - |
local.description.affiliation | [Loosen, Imelda] Lab Bauduin, Enghien, Belgium. | - |
local.description.affiliation | [Reynders, Marijke] AZ Gen Hosp Sint Jan Brugge Oostende AV, Lab Med, Mol Microbiol, Brugge, Belgium. | - |
local.description.affiliation | [Mansoor, Iqbal] Labo Epicura, Ath, Belgium. | - |
local.description.affiliation | [Filippin, Lorenzo] Europa Ziekenhuizen, Brussels, Belgium. | - |
local.description.affiliation | [Cauchie, Mathieu] Heilig Hart HH Hosp Lier, Clin Lab Microbiol, Lier, Belgium. | - |
local.description.affiliation | [Van Even, Ellen; Schiettekatte, Gilberte] Ctr Med Anal, Herentals, Belgium. | - |
local.description.affiliation | [Vandewal, Wouter] AZ Sint Lucas, Brugge, Belgium. | - |
local.description.affiliation | [Glibert, Bart] AZ Glorieux, Ronse, Belgium. | - |
local.description.affiliation | [Matheeussen, Veerle] Univ Hosp Antwerp, Dept Microbiol, Edegem, Belgium. | - |
local.description.affiliation | [Beken, Yolien Van der] Klin Lab Maenhout Waregem, Waregem, Belgium. | - |
local.description.affiliation | [Cartuyvels, Reinoud] Jessa Hosp, Clin Lab, Hasselt, Belgium. | - |
local.description.affiliation | [Steyaert, Sophia] AZ Maria Middelares, Ghent, Belgium. | - |
local.description.affiliation | [Lemmens, Ann] AZ Sint Maarten Hosp, Dept Clin Microbiol, Mechelen, Belgium. | - |
local.description.affiliation | [Garrino, Maria-Grazia] Ctr Hosp Reg Namur, Site Meuse, Namur, Belgium. | - |
local.description.affiliation | [Paridaens, Henry] Citadelle Hosp, Lab Mol Biol, Liege, Belgium. | - |
local.description.affiliation | [Lazarova, Elena] Reg Hosp Haute Senne, Clin Lab, Soignies, Belgium. | - |
local.description.affiliation | [Lissoir, Benedicte] Grand Hop Charleroi St Joseph, Gilly, Belgium. | - |
local.description.affiliation | [Deffontaine, Marine] Ctr Hosp Mouscron, Lab Biol Clin, Mouscron, Belgium. | - |
local.description.affiliation | [Heinrichs, Amelie] Hosp Arlon, Lab Clin Biol, Vivalia, Arlon, Belgium. | - |
local.description.affiliation | [Saegeman, Veroniek] Vitaz Hosp, Clin Lab, St Niklaas, Belgium. | - |
local.description.affiliation | [Padalko, Elizaveta] Ghent Univ Hosp, Dept Lab Med, Ghent, Belgium. | - |
local.description.affiliation | [Lecompte, Amaryl; Vanden Berghe, Wim] Sciensano, Dept Epidemiol & Publ Hlth, Brussels, Belgium. | - |
local.description.affiliation | [Kenyon, Chris] Inst Trop Med, Dept Clin Sci, STI Unit, Antwerp, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.contributor | De Baetselier, Irith | - |
item.contributor | Smet, Hilde | - |
item.contributor | Kehoe, Kaat | - |
item.contributor | Loosen, Imelda | - |
item.contributor | Reynders , Marijke | - |
item.contributor | Mansoor, Iqbal | - |
item.contributor | Filippin, Lorenzo | - |
item.contributor | Cauchie, Mathieu | - |
item.contributor | Van Even, Ellen | - |
item.contributor | Makki, Nadia | - |
item.contributor | Schiettekatte, Gilberte | - |
item.contributor | Vandewal, Wouter | - |
item.contributor | Glibert, Bart | - |
item.contributor | Matheeussen, Veerle | - |
item.contributor | Beken, Yolien Van der | - |
item.contributor | Cartuyvels, Reinoud | - |
item.contributor | Steyaert, Sophia | - |
item.contributor | Lemmens, Ann | - |
item.contributor | Garrino, Maria-Grazia | - |
item.contributor | Paridaens, Henry | - |
item.contributor | Lazarova, Elena | - |
item.contributor | Lissoir, Benedicte | - |
item.contributor | Deffontaine, Marine | - |
item.contributor | Heinrichs, Amelie | - |
item.contributor | Saegeman, Veroniek | - |
item.contributor | PADALKO, Elizaveta | - |
item.contributor | Lecompte, Amaryl | - |
item.contributor | Vanden Berghe, Wim | - |
item.contributor | Kenyon, Chris | - |
item.contributor | Van den Bossche , Dorien | - |
item.accessRights | Open Access | - |
item.fullcitation | De Baetselier, Irith; Smet, Hilde; Kehoe, Kaat; Loosen, Imelda; Reynders , Marijke; Mansoor, Iqbal; Filippin, Lorenzo; Cauchie, Mathieu; Van Even, Ellen; Makki, Nadia; Schiettekatte, Gilberte; Vandewal, Wouter; Glibert, Bart; Matheeussen, Veerle; Beken, Yolien Van der; Cartuyvels, Reinoud; Steyaert, Sophia; Lemmens, Ann; Garrino, Maria-Grazia; Paridaens, Henry; Lazarova, Elena; Lissoir, Benedicte; Deffontaine, Marine; Heinrichs, Amelie; Saegeman, Veroniek; PADALKO, Elizaveta; Lecompte, Amaryl; Vanden Berghe, Wim; Kenyon, Chris & Van den Bossche , Dorien (2024) Estimation of antimicrobial resistance of Mycoplasma genitalium, Belgium, 2022. In: Eurosurveillance, 29 (7) (Art N° 2300318). | - |
crisitem.journal.issn | 1025-496X | - |
crisitem.journal.eissn | 1560-7917 | - |
Appears in Collections: | Research publications |
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eurosurv-29-7-3.pdf | Published version | 240.22 kB | Adobe PDF | View/Open |
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