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http://hdl.handle.net/1942/42972
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DC Field | Value | Language |
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dc.contributor.author | LEYNEN, Nathalie | - |
dc.contributor.author | TYTGAT, Julie | - |
dc.contributor.author | BIJNENS, Karolien | - |
dc.contributor.author | JAENEN, Vincent | - |
dc.contributor.author | Verleysen, Eveline | - |
dc.contributor.author | ARTOIS, Tom | - |
dc.contributor.author | VAN BELLEGHEM, Frank | - |
dc.contributor.author | SAENEN, Nelly | - |
dc.contributor.author | SMEETS, Karen | - |
dc.date.accessioned | 2024-05-16T08:04:47Z | - |
dc.date.available | 2024-05-16T08:04:47Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-05-14T07:50:17Z | - |
dc.identifier.citation | AQUATIC TOXICOLOGY, 270 (Art N° 106895) | - |
dc.identifier.uri | http://hdl.handle.net/1942/42972 | - |
dc.description.abstract | Titanium dioxide nanoparticles (TiO2-NPs) in aquatic environments, originating from urban run-off, product use and post-consumer degradation, interact with aquatic organisms through water and sediments. Thorough toxicity assessment requires comprehensive data across all ecosystem compartments especially the benthic zone, which is currently lacking. Moreover, a proper physicochemical characterization of the particles is needed before and during toxicity assessment. In the present work, we used the planarian Schmidtea mediterranea to investigate the effects of TiO2-NPs (5 mg/L and 50 mg/L). Planarians are benthic organisms that play an important role in the food chain as predators. Our study integrated particle characterization with toxicokinetic and toxicodynamic parameters and showed that the uptake of TiO2-NPs of 21 nm occurred through the epidermis and intestine. Epidermal irritation and mucus production occurred immediately after exposure, and TiO2-NPs induced stronger effects in regenerating organisms. More specifically, TiO2-NPs interfered with neuroregeneration, inducing behavioral effects. A delay in the formation of the anterior commissure between the two brain lobes after seven and nine days of exposure to 50 mg/L was observed, probably as a result of a decrease in stem cell proliferation. Our findings underscore the need to incorporate multiple exposure routes in toxicity screenings. Additionally, we highlight the vulnerability of developing organisms and recommend their inclusion in future risk assessment strategies. | - |
dc.language.iso | en | - |
dc.publisher | - | |
dc.subject.other | Titanium dioxide | - |
dc.subject.other | Nanoparticles | - |
dc.subject.other | Planarians | - |
dc.subject.other | Regeneration | - |
dc.subject.other | Neurodevelopment | - |
dc.subject.other | Uptake | - |
dc.subject.other | Toxicity | - |
dc.title | Assessing the in vivo toxicity of titanium dioxide nanoparticles in Schmidtea mediterranea: uptake pathways and (neuro)developmental outcomes | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 270 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 106895 | - |
dc.identifier.doi | 10.1016/j.aquatox.2024.106895 | - |
local.provider.type | - | |
local.uhasselt.international | yes | - |
item.contributor | LEYNEN, Nathalie | - |
item.contributor | TYTGAT, Julie | - |
item.contributor | BIJNENS, Karolien | - |
item.contributor | JAENEN, Vincent | - |
item.contributor | Verleysen, Eveline | - |
item.contributor | ARTOIS, Tom | - |
item.contributor | VAN BELLEGHEM, Frank | - |
item.contributor | SAENEN, Nelly | - |
item.contributor | SMEETS, Karen | - |
item.embargoEndDate | 2024-11-01 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Embargoed Access | - |
item.fullcitation | LEYNEN, Nathalie; TYTGAT, Julie; BIJNENS, Karolien; JAENEN, Vincent; Verleysen, Eveline; ARTOIS, Tom; VAN BELLEGHEM, Frank; SAENEN, Nelly & SMEETS, Karen (2024) Assessing the in vivo toxicity of titanium dioxide nanoparticles in Schmidtea mediterranea: uptake pathways and (neuro)developmental outcomes. In: AQUATIC TOXICOLOGY, 270 (Art N° 106895). | - |
crisitem.journal.issn | 0166-445X | - |
crisitem.journal.eissn | 1879-1514 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Leynen, Tytgat 2024.pdf Restricted Access | Published version | 10.05 MB | Adobe PDF | View/Open Request a copy |
resub_article TIO2_aquaticTox_review_clean.pdf Until 2024-11-01 | Peer-reviewed author version | 3.36 MB | Adobe PDF | View/Open Request a copy |
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