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Title: | Plasma Metabolite Profiling in the Search for Early-Stage Biomarkers for Lung Cancer: Some Important Breakthroughs | Authors: | MEYNEN, Jill ADRIAENSENS, Peter CRIEL, Maarten LOUIS, Evelyne VANHOVE, Karolien THOMEER, Michiel MESOTTEN, Liesbet DERVEAUX, Elien |
Issue Date: | 2024 | Publisher: | MDPI | Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (9) (Art N° 4690) | Abstract: | Lung cancer is the leading cause of cancer-related mortality worldwide. In order to improve its overall survival, early diagnosis is required. Since current screening methods still face some pitfalls, such as high false positive rates for low-dose computed tomography, researchers are still looking for early biomarkers to complement existing screening techniques in order to provide a safe, faster, and more accurate diagnosis. Biomarkers are biological molecules found in body fluids, such as plasma, that can be used to diagnose a condition or disease. Metabolomics has already been shown to be a powerful tool in the search for cancer biomarkers since cancer cells are characterized by impaired metabolism, resulting in an adapted plasma metabolite profile. The metabolite profile can be determined using nuclear magnetic resonance, or NMR. Although metabolomics and NMR metabolite profiling of blood plasma are still under investigation, there is already evidence for its potential for early-stage lung cancer diagnosis, therapy response, and follow-up monitoring. This review highlights some key breakthroughs in this research field, where the most significant biomarkers will be discussed in relation to their metabolic pathways and in light of the altered cancer metabolism. | Notes: | Adriaensens, P (corresponding author), Hasselt Univ, Inst Mat Res Imo Imomec, Appl & Analyt Chem, NMR Grp, Agoralaan 1, B-3590 Diepenbeek, Belgium. jill.meynen@uhasselt.be; peter.adriaensens@uhasselt.be; maarten.criel@zol.be; evelyne.louis@uzleuven.be; karolien.vanhove@uzleuven.be; michiel.thomeer@zol.be; liesbet.mesotten@zol.be; elien.derveaux@uhasselt.be |
Keywords: | biomarkers;lung cancer;metabolomics;NMR (nuclear magnetic resonance) | Document URI: | http://hdl.handle.net/1942/42998 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms25094690 | ISI #: | 001219816800001 | Rights: | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Plasma Metabolite Profiling in the Search for Early-Stage Biomarkers for Lung Cancer_ Some Important Breakthroughs.pdf | Published version | 5.32 MB | Adobe PDF | View/Open |
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