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http://hdl.handle.net/1942/43016
Title: | Unraveling CMT1A: Models, Mechanisms, and Therapeutic Approaches | Authors: | LIBBERECHT, Karen | Advisors: | Wolfs, Esther Lambrichts, Ivo Van Den Bosch, Ludo |
Issue Date: | 2024 | Abstract: | This work focuses on advancing fundamental research in CMT1A. Addressing the lack of available treatments for this disease, this thesis has three primary aims: developing novel human-based in vitro models, unraveling the underlying mechanisms of PMP22 gene overexpression in Schwann cells at a lysosomal level, and exploring the potential of rebalancing cAMP levels to alleviate the CMT1A phenotype (Fig. 1-4). | Document URI: | http://hdl.handle.net/1942/43016 | Category: | T1 | Type: | Theses and Dissertations |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Doctoraat FINAAL - Karen LIBBERECHT versie2 met cover.pdf Until 2029-05-29 | Published version | 3.98 MB | Adobe PDF | View/Open Request a copy |
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