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http://hdl.handle.net/1942/43034
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DC Field | Value | Language |
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dc.contributor.author | Sin, Yuan Yan | - |
dc.contributor.author | Cameron, Ryan T. | - |
dc.contributor.author | SCHEPERS, Melissa | - |
dc.contributor.author | Macleod, Ruth | - |
dc.contributor.author | Wright, Tom A. | - |
dc.contributor.author | PAES, Dean | - |
dc.contributor.author | van den Hove, Daniel | - |
dc.contributor.author | WILLEMS, Emily | - |
dc.contributor.author | Prickaerts, Jos | - |
dc.contributor.author | Blair, Connor M. | - |
dc.contributor.author | VANMIERLO, Tim | - |
dc.contributor.author | Baillie, George S. | - |
dc.date.accessioned | 2024-06-03T07:58:36Z | - |
dc.date.available | 2024-06-03T07:58:36Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-05-28T12:02:27Z | - |
dc.identifier.citation | FEBS LETTERS, | - |
dc.identifier.uri | http://hdl.handle.net/1942/43034 | - |
dc.description.abstract | Inhibition of the cyclic-AMP degrading enzyme phosphodiesterase type 4 (PDE4) in the brains of animal models is protective in Alzheimer's disease (AD). We show for the first time that enzymes from the subfamily PDE4D not only colocalize with beta-amyloid (A beta) plaques in a mouse model of AD but that A beta directly associates with the catalytic machinery of the enzyme. Peptide mapping suggests that PDE4D is the preferential PDE4 subfamily for A beta as it possesses a unique binding site. Intriguingly, exogenous addition of A beta to cells overexpressing the PDE4D5 longform caused PDE4 activation and a decrease in cAMP. We suggest a novel mechanism where PDE4 longforms can be activated by A beta, resulting in the attenuation of cAMP signalling to promote loss of cognitive function in AD. | - |
dc.description.sponsorship | The authors would like to thank Professor Manuela Zaccolo for supplying the cAMP reporter constructs (EPAC1-cAMPs). This work was supported by a doctoral training studentship from the Biotechnology and Biological Sciences Research Council [grant number BB/F016735/1] | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2024 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | beta-amyloid | - |
dc.subject.other | cyclic AMP | - |
dc.subject.other | PDE4 | - |
dc.title | Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability | - |
dc.type | Journal Contribution | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Baillie, GS (corresponding author), Univ Glasgow, Coll Vet Med & Life Sci, Sch Cardiovasc & Metab Hlth, Glasgow PA124EJ, Scotland. | - |
dc.description.notes | george.baillie@glasgow.ac.uk | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1002/1873-3468.14902 | - |
dc.identifier.pmid | 38724485 | - |
dc.identifier.isi | 001216728800001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Sin, Yuan Yan; Cameron, Ryan T.; Macleod, Ruth; Wright, Tom A.; Blair, Connor M.; Baillie, George S.] Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland. | - |
local.description.affiliation | [Schepers, Melissa; Paes, Dean; Willems, Emily; Vanmierlo, Tim] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Dept Neurosci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Schepers, Melissa; Paes, Dean; van den Hove, Daniel; Willems, Emily; Vanmierlo, Tim; Prickaerts, Jos] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands. | - |
local.description.affiliation | [Baillie, George S.] Univ Glasgow, Coll Vet Med & Life Sci, Sch Cardiovasc & Metab Hlth, Glasgow PA124EJ, Scotland. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Sin, Yuan Yan; Cameron, Ryan T.; SCHEPERS, Melissa; Macleod, Ruth; Wright, Tom A.; PAES, Dean; van den Hove, Daniel; WILLEMS, Emily; Prickaerts, Jos; Blair, Connor M.; VANMIERLO, Tim & Baillie, George S. (2024) Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. In: FEBS LETTERS,. | - |
item.fulltext | With Fulltext | - |
item.contributor | Sin, Yuan Yan | - |
item.contributor | Cameron, Ryan T. | - |
item.contributor | SCHEPERS, Melissa | - |
item.contributor | Macleod, Ruth | - |
item.contributor | Wright, Tom A. | - |
item.contributor | PAES, Dean | - |
item.contributor | van den Hove, Daniel | - |
item.contributor | WILLEMS, Emily | - |
item.contributor | Prickaerts, Jos | - |
item.contributor | Blair, Connor M. | - |
item.contributor | VANMIERLO, Tim | - |
item.contributor | Baillie, George S. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0014-5793 | - |
crisitem.journal.eissn | 1873-3468 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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FEBS Letters - 2024 - Sin - Beta‐amyloid interacts with and activates the long‐form phosphodiesterase PDE4D5 in neuronal.pdf Until 2024-11-09 | Peer-reviewed author version | 2.92 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf | 450.77 kB | Adobe PDF | View/Open |
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