Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/43034
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSin, Yuan Yan-
dc.contributor.authorCameron, Ryan T.-
dc.contributor.authorSCHEPERS, Melissa-
dc.contributor.authorMacleod, Ruth-
dc.contributor.authorWright, Tom A.-
dc.contributor.authorPAES, Dean-
dc.contributor.authorvan den Hove, Daniel-
dc.contributor.authorWILLEMS, Emily-
dc.contributor.authorPrickaerts, Jos-
dc.contributor.authorBlair, Connor M.-
dc.contributor.authorVANMIERLO, Tim-
dc.contributor.authorBaillie, George S.-
dc.date.accessioned2024-06-03T07:58:36Z-
dc.date.available2024-06-03T07:58:36Z-
dc.date.issued2024-
dc.date.submitted2024-05-28T12:02:27Z-
dc.identifier.citationFEBS letters, 598 (13), p. 1591-1604-
dc.identifier.urihttp://hdl.handle.net/1942/43034-
dc.description.abstractInhibition of the cyclic-AMP degrading enzyme phosphodiesterase type 4 (PDE4) in the brains of animal models is protective in Alzheimer's disease (AD). We show for the first time that enzymes from the subfamily PDE4D not only colocalize with beta-amyloid (A beta) plaques in a mouse model of AD but that A beta directly associates with the catalytic machinery of the enzyme. Peptide mapping suggests that PDE4D is the preferential PDE4 subfamily for A beta as it possesses a unique binding site. Intriguingly, exogenous addition of A beta to cells overexpressing the PDE4D5 longform caused PDE4 activation and a decrease in cAMP. We suggest a novel mechanism where PDE4 longforms can be activated by A beta, resulting in the attenuation of cAMP signalling to promote loss of cognitive function in AD.-
dc.description.sponsorshipThe authors would like to thank Professor Manuela Zaccolo for supplying the cAMP reporter constructs (EPAC1-cAMPs). This work was supported by a doctoral training studentship from the Biotechnology and Biological Sciences Research Council [grant number BB/F016735/1]-
dc.language.isoen-
dc.publisherWILEY-
dc.rights2024 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of 1591 Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.-
dc.subject.otherAlzheimer's disease-
dc.subject.otherbeta-amyloid-
dc.subject.othercyclic AMP-
dc.subject.otherPDE4-
dc.titleBeta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability-
dc.typeJournal Contribution-
dc.identifier.epage1604-
dc.identifier.issue13-
dc.identifier.spage1591-
dc.identifier.volume598-
local.format.pages14-
local.bibliographicCitation.jcatA1-
dc.description.notesBaillie, GS (corresponding author), Univ Glasgow, Coll Vet Med & Life Sci, Sch Cardiovasc & Metab Hlth, Glasgow PA124EJ, Scotland.-
dc.description.notesgeorge.baillie@glasgow.ac.uk-
local.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1002/1873-3468.14902-
dc.identifier.pmid38724485-
dc.identifier.isi001216728800001-
local.provider.typewosris-
local.description.affiliation[Sin, Yuan Yan; Cameron, Ryan T.; Macleod, Ruth; Wright, Tom A.; Blair, Connor M.; Baillie, George S.] Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland.-
local.description.affiliation[Schepers, Melissa; Paes, Dean; Willems, Emily; Vanmierlo, Tim] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Dept Neurosci, Diepenbeek, Belgium.-
local.description.affiliation[Schepers, Melissa; Paes, Dean; van den Hove, Daniel; Willems, Emily; Vanmierlo, Tim; Prickaerts, Jos] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.-
local.description.affiliation[Baillie, George S.] Univ Glasgow, Coll Vet Med & Life Sci, Sch Cardiovasc & Metab Hlth, Glasgow PA124EJ, Scotland.-
local.uhasselt.internationalyes-
item.fullcitationSin, Yuan Yan; Cameron, Ryan T.; SCHEPERS, Melissa; Macleod, Ruth; Wright, Tom A.; PAES, Dean; van den Hove, Daniel; WILLEMS, Emily; Prickaerts, Jos; Blair, Connor M.; VANMIERLO, Tim & Baillie, George S. (2024) Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. In: FEBS letters, 598 (13), p. 1591-1604.-
item.accessRightsOpen Access-
item.contributorSin, Yuan Yan-
item.contributorCameron, Ryan T.-
item.contributorSCHEPERS, Melissa-
item.contributorMacleod, Ruth-
item.contributorWright, Tom A.-
item.contributorPAES, Dean-
item.contributorvan den Hove, Daniel-
item.contributorWILLEMS, Emily-
item.contributorPrickaerts, Jos-
item.contributorBlair, Connor M.-
item.contributorVANMIERLO, Tim-
item.contributorBaillie, George S.-
item.fulltextWith Fulltext-
crisitem.journal.issn0014-5793-
crisitem.journal.eissn1873-3468-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
FEBS Letters - 2024 - Sin - Beta‐amyloid interacts with and activates the long‐form phosphodiesterase PDE4D5 in neuronal.pdfPeer-reviewed author version2.92 MBAdobe PDFView/Open
auteursversie.pdfPublished version450.77 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

2
checked on Oct 11, 2025

WEB OF SCIENCETM
Citations

2
checked on Oct 11, 2025

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.