Acoramidis in Transthyretin Amyloid Cardiomyopathy

Abstract

To the Editor: In a phase 3 trial of acoramidis for transthyretin amyloid cardiomyopathy, Gillmore et al. (Jan. 11 issue)(1) used the Finkelstein-Schoenfeld test to assess the hierarchical composite primary outcome. They expressed the treatment effect as a win ratio, thereby following the initial presentation of the analysis of a prioritized outcome.(2) However, the generalized pairwise comparison method, to which the Finkelstein-Schoenfeld test and the win ratio belong, has evolved substantially since this first application.(3) To aid the interpretation of the results, it is now recommended that the proportions of wins and losses for each outcome are reported to understand the . . .