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http://hdl.handle.net/1942/43145
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DC Field | Value | Language |
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dc.contributor.author | Salon, A | - |
dc.contributor.author | Çiftci, GM | - |
dc.contributor.author | Zubac, D | - |
dc.contributor.author | Simunic, B | - |
dc.contributor.author | Pisot, R | - |
dc.contributor.author | Narici, M | - |
dc.contributor.author | Fredriksen, PM | - |
dc.contributor.author | Nkeh-Chungag, BN | - |
dc.contributor.author | Sourij, H | - |
dc.contributor.author | Sery, O | - |
dc.contributor.author | Schmid-Zalaudek, K | - |
dc.contributor.author | Steuber, B | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.contributor.author | Goswami, N | - |
dc.date.accessioned | 2024-06-13T13:54:53Z | - |
dc.date.available | 2024-06-13T13:54:53Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-06-13T13:49:58Z | - |
dc.identifier.citation | Scientific Reports, 13 (1) (Art N° 19258) | - |
dc.identifier.uri | http://hdl.handle.net/1942/43145 | - |
dc.description.abstract | Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 ± 4.7 years; body mass index: 23.6 ± 2.5 kg·m-2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning. | - |
dc.description.sponsorship | Funding Te present study was funded by ASI, MARS-PRE, Project, n. DC-VUM-2017-006. Te authors thank ASI for granting these funds to allow all the experiments to be performed. Acknowledgements Te authors thank the participants for their priceless time and efort in collecting the data. We sincerely thank the Doctoral School of Translational Molecular and Cellular Bioscience at the Medical University of Graz for their vital resources that signifcantly contributed to the completion of this publication. | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.rights | The Author(s) 2023. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | - |
dc.subject.other | Male | - |
dc.subject.other | Humans | - |
dc.subject.other | Bed Rest | - |
dc.subject.other | Retinal Vessels | - |
dc.subject.other | Fluorescein Angiography | - |
dc.subject.other | Retinal Artery | - |
dc.subject.other | Retinal Vein | - |
dc.title | Retinal venular vessel diameters are smaller during ten days of bed rest | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | HEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 19258 | - |
dc.identifier.doi | 10.1038/s41598-023-46177-x | - |
dc.identifier.pmid | 37935771 | - |
dc.identifier.isi | 001101369900008 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | yes | - |
item.fullcitation | Salon, A; Çiftci, GM; Zubac, D; Simunic, B; Pisot, R; Narici, M; Fredriksen, PM; Nkeh-Chungag, BN; Sourij, H; Sery, O; Schmid-Zalaudek, K; Steuber, B; DE BOEVER, Patrick & Goswami, N (2023) Retinal venular vessel diameters are smaller during ten days of bed rest. In: Scientific Reports, 13 (1) (Art N° 19258). | - |
item.fulltext | With Fulltext | - |
item.contributor | Salon, A | - |
item.contributor | Çiftci, GM | - |
item.contributor | Zubac, D | - |
item.contributor | Simunic, B | - |
item.contributor | Pisot, R | - |
item.contributor | Narici, M | - |
item.contributor | Fredriksen, PM | - |
item.contributor | Nkeh-Chungag, BN | - |
item.contributor | Sourij, H | - |
item.contributor | Sery, O | - |
item.contributor | Schmid-Zalaudek, K | - |
item.contributor | Steuber, B | - |
item.contributor | DE BOEVER, Patrick | - |
item.contributor | Goswami, N | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2045-2322 | - |
crisitem.journal.eissn | 2045-2322 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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s41598-023-46177-x.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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