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http://hdl.handle.net/1942/43171
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DC Field | Value | Language |
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dc.contributor.author | Fischer, N | - |
dc.contributor.author | Moreels, S | - |
dc.contributor.author | Dauby, N | - |
dc.contributor.author | Reynders , M | - |
dc.contributor.author | Petit, E | - |
dc.contributor.author | Gérard, M | - |
dc.contributor.author | Lacor, P | - |
dc.contributor.author | Daelemans, S | - |
dc.contributor.author | Lissoir, B | - |
dc.contributor.author | Holemans, X | - |
dc.contributor.author | MAGERMAN, Koen | - |
dc.contributor.author | Jouck, D | - |
dc.contributor.author | Bourgeois, M | - |
dc.contributor.author | Delaere, B | - |
dc.contributor.author | Quoilin, S | - |
dc.contributor.author | Van Gucht, S | - |
dc.contributor.author | Thomas, I | - |
dc.contributor.author | Bossuyt, N | - |
dc.contributor.author | Barbezange, C | - |
dc.date.accessioned | 2024-06-17T08:18:46Z | - |
dc.date.available | 2024-06-17T08:18:46Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-06-17T08:08:12Z | - |
dc.identifier.citation | Eurosurveillance, 28 (29) (Art. N° 2300056) | - |
dc.identifier.uri | http://hdl.handle.net/1942/43171 | - |
dc.description.abstract | BackgroundKnowledge on the burden attributed to influenza viruses vs other respiratory viruses in children hospitalised with severe acute respiratory infections (SARI) in Belgium is limited.AimThis observational study aimed at describing the epidemiology and assessing risk factors for severe disease.MethodsWe retrospectively analysed data from routine national sentinel SARI surveillance in Belgium. Respiratory specimens collected during winter seasons 2011 to 2020 were tested by multiplex real-time quantitative PCR (RT-qPCR) for influenza and other respiratory viruses. Demographic data and risk factors were collected through questionnaires. Patients were followed-up for complications or death during hospital stay. Analysis focused on children younger than 15 years. Binomial logistic regression was used to identify risk factors for severe disease in relation to infection status.ResultsDuring the winter seasons 2011 to 2020, 2,944 specimens met the study case definition. Complications were more common in children with underlying risk factors, especially asthma (adjusted risk ratio (aRR): 1.87; 95% confidence interval (CI): 1.46-2.30) and chronic respiratory disease (aRR: 1.88; 95% CI: 1.44-2.32), regardless of infection status and age. Children infected with non-influenza respiratory viruses had a 32% higher risk of complications (aRR: 1.32; 95% CI: 1.06-1.66) compared with children with influenza only.ConclusionMulti-virus testing in children with SARI allows a more accurate assessment of the risk of complications and attribution of burden to respiratory viruses beyond influenza. Children with asthma and respiratory disease should be prioritised for clinical care, regardless of their virological test result and age, and targeted for prevention campaigns. | - |
dc.description.sponsorship | Funding statement Funders: Belgian Federal Public Service ‘Health, Food Chain Safety, and Environment’, Belgian National Insurance Health Care (INAMI/RIZIV), Regional Health Authorities (Flanders: AZG, Brussels: COCOM, Wallonia: AVIQ). The funders of the SARI surveillance played no role in the study design, data collection, data analysis, data interpretation, or the writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Acknowledgements The authors thank the NIC technical staff for technical assistance and the staff of the hospitals involved in the recruitment of the SARI cases. N.F. was a fellow in the European Public Health Microbiology Program funded through the European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control. N.D. is a post-doctorate clinical master specialist of the F.R.S-FNRS. This work was published as a preprint available at SSRN: http://dx.doi.org/10.2139/ssrn.4308768. | - |
dc.language.iso | en | - |
dc.publisher | EUR CENTRE DIS PREVENTION & CONTROL | - |
dc.rights | This article is copyright of the authors or their affiliated institutions, 2023. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. | - |
dc.subject.other | burden of disease | - |
dc.subject.other | influenza | - |
dc.subject.other | non-influenza respiratory virus | - |
dc.subject.other | risk factor | - |
dc.subject.other | severity | - |
dc.subject.other | Child | - |
dc.subject.other | Humans | - |
dc.subject.other | Infant | - |
dc.subject.other | Belgium | - |
dc.subject.other | Child, Hospitalized | - |
dc.subject.other | Retrospective Studies | - |
dc.subject.other | Seasons | - |
dc.subject.other | Respiratory Tract Infections | - |
dc.subject.other | Influenza, Human | - |
dc.subject.other | Viruses | - |
dc.subject.other | Pneumonia | - |
dc.subject.other | Asthma | - |
dc.title | Influenza versus other respiratory viruses-assessing severity among hospitalised children, Belgium, 2011 to 2020 | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 29 | - |
dc.identifier.volume | 28 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | TOMTEBODAVAGEN 11A, STOCKHOLM 171 83, SWEDEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2300056 | - |
dc.identifier.doi | 10.2807/1560-7917.ES.2023.28.29.2300056 | - |
dc.identifier.pmid | 37470740 | - |
dc.identifier.isi | 001047900300001 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.fullcitation | Fischer, N; Moreels, S; Dauby, N; Reynders , M; Petit, E; Gérard, M; Lacor, P; Daelemans, S; Lissoir, B; Holemans, X; MAGERMAN, Koen; Jouck, D; Bourgeois, M; Delaere, B; Quoilin, S; Van Gucht, S; Thomas, I; Bossuyt, N & Barbezange, C (2023) Influenza versus other respiratory viruses-assessing severity among hospitalised children, Belgium, 2011 to 2020. In: Eurosurveillance, 28 (29) (Art. N° 2300056). | - |
item.contributor | Fischer, N | - |
item.contributor | Moreels, S | - |
item.contributor | Dauby, N | - |
item.contributor | Reynders , M | - |
item.contributor | Petit, E | - |
item.contributor | Gérard, M | - |
item.contributor | Lacor, P | - |
item.contributor | Daelemans, S | - |
item.contributor | Lissoir, B | - |
item.contributor | Holemans, X | - |
item.contributor | MAGERMAN, Koen | - |
item.contributor | Jouck, D | - |
item.contributor | Bourgeois, M | - |
item.contributor | Delaere, B | - |
item.contributor | Quoilin, S | - |
item.contributor | Van Gucht, S | - |
item.contributor | Thomas, I | - |
item.contributor | Bossuyt, N | - |
item.contributor | Barbezange, C | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1025-496X | - |
crisitem.journal.eissn | 1560-7917 | - |
Appears in Collections: | Research publications |
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eurosurv-28-29-1.pdf | Published version | 326.35 kB | Adobe PDF | View/Open |
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