Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/4320
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dc.contributor.authorLIU, Feng-
dc.contributor.authorWETS, Geert-
dc.date.accessioned2007-12-20T15:48:18Z-
dc.date.available2007-12-20T15:48:18Z-
dc.date.issued2005-
dc.identifier.citation27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: vol. 1-7. p. 2805-2808.-
dc.identifier.isbn0-7803-8740-6-
dc.identifier.issn1094-687X-
dc.identifier.urihttp://hdl.handle.net/1942/4320-
dc.description.abstractProteolytic processing occurs predominantly at basic amino acid residues. The existence of the cleavage sites not recognized by rules proposed in previous studies prompts us to test whether, and to what extent, the sites cleave. Due to the imbalanced cleavage site database from SWISS, Smote combined with Tomek links is applied to over-sample the data. A neural network method is then developed to predict the probabilities of proteolytic processing occurrences at the sites in neuropeptide precursors. The sensitivities are 91%, 93%, 91%, 90%, 79% and 83% for KR, RR, RK, KK, R and K, respectively, which is significantly better than previous prediction schemes.-
dc.language.isoen-
dc.publisherEngineering in Medicine and Biology Society-
dc.relation.ispartofseriesPROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY-
dc.titleA neural network method for prediction of proteolytic cleavage sites in neuropeptide precursors-
dc.typeProceedings Paper-
local.bibliographicCitation.conferencedateAUG 31-SEP 03, 2005-
local.bibliographicCitation.conferencename27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY-
local.bibliographicCitation.conferenceplaceShanghai, PEOPLES R CHINA-
dc.identifier.epage2808-
dc.identifier.spage2805-
dc.identifier.volume1-7-
local.bibliographicCitation.jcatC1-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatC1-
dc.identifier.doi10.1109/IEMBS.2005.1617056-
dc.identifier.isi000238998402158-
local.bibliographicCitation.btitle27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY-
item.fulltextNo Fulltext-
item.contributorLIU, Feng-
item.contributorWETS, Geert-
item.fullcitationLIU, Feng & WETS, Geert (2005) A neural network method for prediction of proteolytic cleavage sites in neuropeptide precursors. In: 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: vol. 1-7. p. 2805-2808..-
item.accessRightsClosed Access-
item.validationecoom 2007-
Appears in Collections:Research publications
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