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http://hdl.handle.net/1942/43298
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DC Field | Value | Language |
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dc.contributor.author | Neven, Dolien | - |
dc.contributor.author | ISSAYAMA, Luidy | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | WILSON, David | - |
dc.date.accessioned | 2024-06-28T09:58:18Z | - |
dc.date.available | 2024-06-28T09:58:18Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-06-26T13:02:21Z | - |
dc.identifier.citation | DNA repair (Print), 139 (Art N° 103678) | - |
dc.identifier.uri | http://hdl.handle.net/1942/43298 | - |
dc.description.abstract | Alzheimer disease (AD) is the most prominent form of dementia and has received considerable attention due to its growing burden on economic, healthcare and basic societal infrastructures. The two major neuropathological hallmarks of AD, i.e., extracellular amyloid beta (A beta) peptide plaques and intracellular hyperphosphorylated Tau neurofibrillary tangles, have been the focus of much research, with an eye on understanding underlying disease mechanisms and identifying novel therapeutic avenues. One often overlooked aspect of AD is how A beta and Tau may, through indirect and direct mechanisms, affect genome integrity. Herein, we review evidence that A beta and Tau abnormalities induce excessive genomic stress and impair genome maintenance mechanisms, events that can promote DNA damage-induced neuronal cell loss and associated brain atrophy. | - |
dc.description.sponsorship | This work was supported by grants to D.M.W.III (Stichting Alzheimer Onderzoek, SAO-FRA 2021/0009, Belgium) and I.D.W. (Stichting Alzheimer Onderzoek, SAO-FRA 2022/0006, Belgium; and Fonds Wetenschappelijk Onderzoek - Vlaanderen (FWO G0C6819N)). Figures were created using BioRender.com, accessed on 31 January 2024. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2024 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Alzheimer disease | - |
dc.subject.other | DNA damage | - |
dc.subject.other | DNA repair | - |
dc.subject.other | Amyloid beta | - |
dc.subject.other | Tau | - |
dc.subject.other | Neurodegeneration | - |
dc.title | Genomic stress and impaired DNA repair in Alzheimer disease | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 139 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Wilson, DM (corresponding author), Hasselt Univ, Biomed Res Inst, BIOMED, B-3500 Hasselt, Belgium. | - |
dc.description.notes | david.wilson@uhasselt.be | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 103678 | - |
dc.identifier.doi | 10.1016/j.dnarep.2024.103678 | - |
dc.identifier.pmid | 38669748 | - |
dc.identifier.isi | 001233922100001 | - |
dc.contributor.orcid | Neven, Jolien/0009-0009-0268-1691 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Neven, Dolien; Issayama, Luidy Kazuo; Dewachter, Ilse; Wilson, David M.] Hasselt Univ, Biomed Res Inst, BIOMED, B-3500 Hasselt, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | Neven, Dolien; ISSAYAMA, Luidy; DEWACHTER, Ilse & WILSON, David (2024) Genomic stress and impaired DNA repair in Alzheimer disease. In: DNA repair (Print), 139 (Art N° 103678). | - |
item.embargoEndDate | 2025-01-01 | - |
item.accessRights | Embargoed Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Neven, Dolien | - |
item.contributor | ISSAYAMA, Luidy | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | WILSON, David | - |
crisitem.journal.issn | 1568-7864 | - |
crisitem.journal.eissn | 1568-7856 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Genomic stress and impaired DNA repair in Alzheimer disease.pdf Restricted Access | Published version | 2.02 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf Until 2025-01-01 | Peer-reviewed author version | 1.26 MB | Adobe PDF | View/Open Request a copy |
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