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Title: | Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model | Authors: | MARTENS, Nikita ZHAN, Na Yam, Sammie C. Leijten, Frank P. J. Palumbo, Marcella Caspers, Martien TIANE, Assia Friedrichs, Silvia Li , Yanlin van van der Zee, Leonie Voortman, Gardi Zimetti, Francesca Jaarsma, Dick Verschuren, Lars Jonker, Johan W. Kuipers, Folkert Luetjohann, Dieter VANMIERLO, Tim Mulder, Monique T. |
Issue Date: | 2024 | Publisher: | MDPI | Source: | Nutrients, 16 (11) (Art N° 1614) | Abstract: | We previously demonstrated that diet supplementation with seaweed Sargassum fusiforme (S. fusiforme) prevented AD-related pathology in a mouse model of Alzheimer's Disease (AD). Here, we tested a lipid extract of seaweed Himanthalia elongata (H. elongata) and a supercritical fluid (SCF) extract of S. fusiforme that is free of excess inorganic arsenic. Diet supplementation with H. elongata extract prevented cognitive deterioration in APPswePS1 Delta E9 mice. Similar trends were observed for the S. fusiforme SCF extract. The cerebral amyloid-beta plaque load remained unaffected. However, IHC analysis revealed that both extracts lowered glial markers in the brains of APPswePS1 Delta E9 mice. While cerebellar cholesterol concentrations remained unaffected, both extracts increased desmosterol, an endogenous LXR agonist with anti-inflammatory properties. Both extracts increased cholesterol efflux, and particularly, H. elongata extract decreased the production of pro-inflammatory cytokines in LPS-stimulated THP-1-derived macrophages. Additionally, our findings suggest a reduction of AD-associated phosphorylated tau and promotion of early oligodendrocyte differentiation by H. elongata. RNA sequencing on the hippocampus of one-week-treated APPswePS1 Delta E9 mice revealed effects of H. elongata on, amongst others, acetylcholine and synaptogenesis signaling pathways. In conclusion, extracts of H. elongata and S. fusiforme show potential to reduce AD-related pathology in APPswePS1 Delta E9 mice. Increasing desmosterol concentrations may contribute to these effects by dampening neuroinflammation. | Notes: | Mulder, MT (corresponding author), Erasmus MC, Dept Internal Med, Sect Pharmacol & Vasc Med, NL-3015 GE Rotterdam, Netherlands. marcella.palumbo@unipr.it; y.li@erasmusmc.nl; g.voortman@erasmusmc.nl; j.w.jonker@umcg.nl; dieter.luetjohann@ukbonn.de; tim.vanmierlo@uhasselt.be; m.t.mulder@erasmusmc.nl |
Keywords: | Alzheimer's disease;cholesterol metabolism;seaweed;oxyphytosterols;liver X receptors;inflammation | Document URI: | http://hdl.handle.net/1942/43335 | e-ISSN: | 2072-6643 | DOI: | 10.3390/nu16111614 | ISI #: | WOS:001245279800001 | Rights: | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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