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http://hdl.handle.net/1942/43359
Title: | Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures | Authors: | Heemels, Robin E. Ademi, Sian HEHL, Melina |
Issue Date: | 2024 | Publisher: | Source: | Clinical neurophysiology, 165 , p. 64 -75 | Abstract: | Objective: Investigating the optimal interstimulus interval (ISI) and the 24-hour test–retest reliability for intrahemispheric dorsal premotor cortex (PMd) – primary motor cortex (M1) connectivity using dual-site transcranial magnetic stimulation (dsTMS). Methods: In 21 right-handed adults, left intrahemispheric PMd–M1 connectivity has been investigated with a stacked-coil dsTMS setup (conditioning stimulus: 75% of resting motor threshold; test stimulus: eliciting MEPs of 1–1.5 mV) at ISIs of 3, 5–8, and 10 ms. Additionally, M1–M1 short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were investigated to assess comparability to standard paired-pulse setups. Results: Conditioning PMd led to significant inhibition of M1 output at ISIs of 3 and 5 ms, whereas 10 ms resulted in facilitation (all, p < 0.001), with a fair test–retest reliability for 3 (ICC: 0.47) and 6 ms (ICC: 0.44) ISIs. Replication of SICI (p < 0.001) and ICF (p = 0.017) was successful, with excellent test–retest reliability for SICI (ICC: 0.81). Conclusion: This dsTMS setup can probe the inhibitory and facilitatory PMd–M1 connections, as well as reliably replicate SICI and ICF paradigms. Significance: The stacked-coil dsTMS setup for investigating intrahemispheric PMd–M1 connectivity offers promising possibilities to better understand motor control. | Keywords: | Transcranial magnetic stimulation (TMS);Dual-site TMS (dsTMS);Intrahemispheric interaction;Dorsal premotor cortex (PMd);Effective connectivity;Reliability | Document URI: | http://hdl.handle.net/1942/43359 | ISSN: | 1388-2457 | e-ISSN: | 1872-8952 | DOI: | 10.1016/j.clinph.2024.06.006 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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dsTMS_reliability_Supplementary_V3.docx Restricted Access | Supplementary material | 2.15 MB | Microsoft Word | View/Open Request a copy |
1-s2.0-S1388245724001792-main.pdf Restricted Access | Published version | 1.22 MB | Adobe PDF | View/Open Request a copy |
dsTMS_Manuscript_v6_FIN_author_version.pdf Until 2025-01-01 | Peer-reviewed author version | 1.01 MB | Adobe PDF | View/Open Request a copy |
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