Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/43423
Title: | Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging | Authors: | STOKS, Job Patel, Kiran Haresh Kumar VAN REES, Bianca Nguyen, Uyen Chau Mihl, Casper Deissler, Peter M. ter Bekke, Rachel M. A. Peeters , Ralf VIJGEN, Johan DENDALE, Paul Ng, Fu Siong Cluitmans, Matthijs J. M. Volders, Paul G. A. |
Issue Date: | 2024 | Publisher: | OXFORD UNIV PRESS | Source: | Europace (London, England), 26 (7) (Art N° euae172) | Abstract: | Aims Although electrical activity of the normal human heart is well characterized by the electrocardiogram, detailed insights into within-subject and between-subject variations of ventricular activation and recovery by noninvasive electroanatomic mapping are lacking. We characterized human epicardial activation and recovery within and between normal subjects using non-invasive electrocardiographic imaging (ECGI) as a basis to better understand pathology. Methods and results Epicardial activation and recovery were assessed by ECGI in 22 normal subjects, 4 subjects with bundle branch block (BBB) and 4 with long-QT syndrome (LQTS). We compared characteristics between the ventricles [left ventricle (LV) and right ventricle (RV)], sexes, and age groups (<50/>= 50years). Pearson's correlation coefficient (CC) was used for within-subject and between-subject comparisons. Age of normal subjects averaged 49 +/- 14 years, 6/22 were male, and no structural/electrical heart disease was present. The average activation time was longer in LV than in RV, but not different by sex or age. Electrical recovery was similar for the ventricles, but started earlier and was on average shorter in males. Median CCs of between-subject comparisons of the ECG signals, activation, and recovery patterns were 0.61, 0.32, and 0.19, respectively. Within-subject beat-to-beat comparisons yielded higher CCs (0.98, 0.89, and 0.82, respectively). Activation and/or recovery patterns of patients with BBB or LQTS contrasted significantly with those found in the normal population. Conclusion Activation and recovery patterns vary profoundly between normal subjects, but are stable individually beat to beat, with a male preponderance to shorter recovery. Individual characterization by ECGI at baseline serves as reference to better understand the emergence, progression, and treatment of electrical heart disease. [GRAPHICS] . | Notes: | Volders, PGA (corresponding author), Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Dept Cardiol, Maastricht, Netherlands. p.volders@maastrichtuniversity.nl |
Keywords: | ECGI;Ventricles;Electrophysiology;Variability;Normal;Dynamics | Document URI: | http://hdl.handle.net/1942/43423 | ISSN: | 1099-5129 | e-ISSN: | 1532-2092 | DOI: | 10.1093/europace/euae172 | ISI #: | WOS:001263321800002 | Rights: | The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging.pdf | Published version | 13.24 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.