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http://hdl.handle.net/1942/43429
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DC Field | Value | Language |
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dc.contributor.author | Moreel, Lien | - |
dc.contributor.author | Betrains, Albrecht | - |
dc.contributor.author | Boeckxstaens, Lennert | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Van Laere, Koen | - |
dc.contributor.author | De Langhe, Ellen | - |
dc.contributor.author | Vanderschueren, Steven | - |
dc.contributor.author | Blockmans, Daniel | - |
dc.date.accessioned | 2024-07-24T07:19:01Z | - |
dc.date.available | 2024-07-24T07:19:01Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-07-24T06:03:54Z | - |
dc.identifier.citation | Seminars in arthritis and rheumatism (Print), 68 (Art N° 152499) | - |
dc.identifier.uri | http://hdl.handle.net/1942/43429 | - |
dc.description.abstract | Objectives: To evaluate differences in presentation and outcome of giant cell arteritis (GCA) patients with and without polymyalgia rheumatica (PMR) symptoms. Methods: Consecutive patients diagnosed with GCA between 2000 and 2020 and followed for >= 12 months at the University Hospitals Leuven (Belgium), were included retrospectively. Results: We included 398 GCA patients, of which 181 (45%) with PMR symptoms. Patients with PMR symptoms had a longer symptom duration (11 vs 6 weeks, p < 0.001). They less frequently reported fever (19% vs 28%, p = 0.030) and fatigue (52% vs 64%, p = 0.015) and tended to have less permanent vision loss (12% vs 19%, p = 0.052). There was no difference in the cumulative oral GC dose at 2 years (4.4 vs 4.3 g methylprednisolone, p = 0.571). However, those with PMR symptoms were treated with higher GC doses during subsequent follow-up (p < 0.05 from 38 months after diagnosis) and had a lower probability of stopping GC (62% vs 71%, HR 0.74 [95%CI 0.58-0.94], p = 0.018) with a longer median duration of GC treatment (29 vs 23 months, p = 0.021). In addition, presence of PMR symptoms was associated with an increased risk of relapse (64% vs 51%, HR 1.38 [95%CI 1.06-1.79], p = 0.017) with a higher number of relapses (1.47 [95%CI 1.30-1.65] vs 1.16 relapses [95%CI 1.02-1.31], p = 0.007). Patients with PMR symptoms less frequently developed thoracic aortic aneurysms during follow-up (3% vs 11%, p = 0.005). Conclusion: GCA patients with PMR symptoms had more recalcitrant disease with a higher risk of relapse and longer duration of GC treatment with need for higher GC doses. | - |
dc.description.sponsorship | No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this article. | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.rights | 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. | - |
dc.subject.other | Giant cell arteritis - GCA | - |
dc.subject.other | Polymyalgia rheumatica - PMR | - |
dc.title | Polymyalgia rheumatica is a risk factor for more recalcitrant disease in giant cell arteritis: A retrospective cohort study | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 68 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Moreel, L (corresponding author), Univ Hosp Leuven, Gen Internal Med Dept, Herestr 49, B-3000 Leuven, Belgium. | - |
dc.description.notes | Lien.Moreel@uzleuven.be | - |
local.publisher.place | 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 152499 | - |
dc.identifier.doi | 10.1016/j.semarthrit.2024.152499 | - |
dc.identifier.pmid | 38968729 | - |
dc.identifier.isi | 001266612300001 | - |
dc.contributor.orcid | Moreel, Lien/0000-0002-7613-4801 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Moreel, Lien; Betrains, Albrecht; Vanderschueren, Steven; Blockmans, Daniel] UZ Leuven, Dept Gen Internal Med, Leuven, Belgium. | - |
local.description.affiliation | [Moreel, Lien; Betrains, Albrecht; Vanderschueren, Steven; Blockmans, Daniel] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Boeckxstaens, Lennert; Van Laere, Koen] UZ Leuven, Dept Nucl Med, Leuven, Belgium. | - |
local.description.affiliation | [Boeckxstaens, Lennert; Van Laere, Koen] Katholieke Univ Leuven, Dept Imaging & Pathol Nucl Med & Mol Imaging, Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat L BioSta, Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Hasselt Univ, Leuven, Belgium. | - |
local.description.affiliation | [De Langhe, Ellen] UZ Leuven, Dept Rheumatol, Leuven, Belgium. | - |
local.description.affiliation | [De Langhe, Ellen] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium. | - |
local.description.affiliation | [De Langhe, Ellen; Vanderschueren, Steven; Blockmans, Daniel] European Reference Network Immunodeficiency Autoin, Utrecht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.contributor | Moreel, Lien | - |
item.contributor | Betrains, Albrecht | - |
item.contributor | Boeckxstaens, Lennert | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Van Laere, Koen | - |
item.contributor | De Langhe, Ellen | - |
item.contributor | Vanderschueren, Steven | - |
item.contributor | Blockmans, Daniel | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Moreel, Lien; Betrains, Albrecht; Boeckxstaens, Lennert; MOLENBERGHS, Geert; Van Laere, Koen; De Langhe, Ellen; Vanderschueren, Steven & Blockmans, Daniel (2024) Polymyalgia rheumatica is a risk factor for more recalcitrant disease in giant cell arteritis: A retrospective cohort study. In: Seminars in arthritis and rheumatism (Print), 68 (Art N° 152499). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0049-0172 | - |
crisitem.journal.eissn | 1532-866X | - |
Appears in Collections: | Research publications |
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