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Title: | Immune checkpoint inhibition in early-stage non-small cell lung cancer | Authors: | CUPPENS, Kristof Du Pont, Bert Knegjens, Joost MAES, Brigitte Baas, Paul |
Issue Date: | 2024 | Publisher: | ELSEVIER IRELAND LTD | Source: | Lung cancer, 193 (Art N° 107855) | Abstract: | The introduction of immune checkpoint inhibitors significantly advanced outcomes in both metastatic and locally advanced non-small cell lung cancer. Despite these advancements, the 5-year survival rate remains suboptimal. Even in early-stage disease a significant portion of patients relapse and die from metastatic progression. The integration of immunotherapy in the management of early-stage NSCLC demonstrated promising results, supported by a plethora of positive clinical trials conducted in recent years. Nonetheless, numerous questions persist. In this manuscript we comprehensively review the currently available data on adjuvant, neoadjuvant, and perioperative treatment strategies. We also address the challenges inherent to these approaches from different stakeholders' perspective. | Notes: | Cuppens, K (corresponding author), Jessa Hosp, Dept Pulmonol & Thorac Oncol, Stadsomvaart 11, B-3500 Hasselt, Belgium. kristof.cuppens@jessazh.be |
Keywords: | Non-small cell lung cancer;Early stage;Immune checkpoint inhibition;Neoadjuvant;Perioperative | Document URI: | http://hdl.handle.net/1942/43430 | ISSN: | 0169-5002 | e-ISSN: | 1872-8332 | DOI: | 10.1016/j.lungcan.2024.107855 | ISI #: | 001259250000001 | Rights: | 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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