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Title: | Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders | Authors: | Kisby, Glen E. WILSON, David Spencer, Peter S. |
Issue Date: | 2024 | Publisher: | MDPI | Source: | International journal of molecular sciences (Print), 25 (13) (Art N° 7221) | Abstract: | Decades of research have identified genetic and environmental factors involved in age-related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders. Genomic instability, i.e., the loss of genome integrity, is a common feature among both neurodegenerative (mayo-trophic lateral sclerosis, Parkinson's disease, Alzheimer's disease) and psychiatric (schizophrenia, autism, bipolar depression) disorders. Genomic instability is associated with the accumulation of persistent DNA damage and the activation of DNA damage response (DDR) pathways, as well as pathologic neuronal cell loss or senescence. Typically, DDR signaling ensures that genomic and proteomic homeostasis are maintained in both dividing cells, including neural progenitors, and post-mitotic neurons. However, dysregulation of these protective responses, in part due to aging or environmental insults, contributes to the progressive development of neurodegenerative and/or psychiatric disorders. In this Special Issue, we introduce and highlight the overlap between neurodegenerative diseases and neuropsychiatric disorders, as well as the emerging clinical, genomic, and molecular evidence for the contributions of DNA damage and aberrant DNA repair. Our goal is to illuminate the importance of this subject to uncover possible treatment and prevention strategies for relevant devastating brain diseases. | Notes: | Kisby, GE (corresponding author), Western Univ Hlth Sci, Coll Osteopath Med Pacific Northwest, Dept Biomed Sci, Lebanon, OR 97355 USA.; Spencer, PS (corresponding author), Oregon Hlth & Sci Univ OHSU, Oregon Inst Occupat Hlth Sci, Sch Med, Dept Neurol, Portland, OR 97239 USA. gkisby@westernu.edu; david.wilson@uhasslet.be; spencer@ohsu.edu |
Keywords: | genomic instability;genomic stress;DNA damage response (DDR);DNA repair;environment | Document URI: | http://hdl.handle.net/1942/43464 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms25137221 | ISI #: | 001269764200001 | Rights: | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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