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http://hdl.handle.net/1942/43590
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DC Field | Value | Language |
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dc.contributor.author | Hanley-Cook, Giles T. | - |
dc.contributor.author | Bastos-Moreira, Yuri | - |
dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | Dailey-Chwalibóg, Trenton | - |
dc.contributor.author | Toe, Laeticia Celine | - |
dc.contributor.author | Kok, Brenda de | - |
dc.contributor.author | Ouédraogo, Lionel | - |
dc.contributor.author | Argaw, Alemayehu | - |
dc.contributor.author | Tesfamariam, Kokeb | - |
dc.contributor.author | Kolsteren, Patrick | - |
dc.contributor.author | Huybregts, Lieven | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Saeger, Sarah De | - |
dc.contributor.author | Boevre, Marthe De | - |
dc.contributor.author | Lachat, Carl | - |
dc.date.accessioned | 2024-08-27T12:12:54Z | - |
dc.date.available | 2024-08-27T12:12:54Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-08-07T08:24:49Z | - |
dc.identifier.citation | Food Science and Human Wellness, 15 | - |
dc.identifier.uri | http://hdl.handle.net/1942/43590 | - |
dc.description.abstract | Background: Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease, such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives: We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome. Design: We conducted a randomized controlled trial in rural Burkina Faso, among pregnant females (15−40 years old) enrolled at < 21 weeks of gestation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants, respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms. Results: We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β = -0.010 (95% CI: -0.057, 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI: -0.203, 0.073); | - |
dc.description.sponsorship | Funding The MIcronutriments pour la SAnté de la Mère et de l’Enfant III (MISAME-III) efficacy trial was supported by the Bill & Melinda Gates Foundation (Grant number: OPP1175213). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The telomere length and mitochondrial DNA analysis was supported by the Research Foundation Flanders (Grant numbers: 12X9620N and 12X9623N) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant number: 946192, HUMYCO) | - |
dc.language.iso | en | - |
dc.publisher | - | |
dc.subject.other | balanced-energy protein | - |
dc.subject.other | Burkina Faso | - |
dc.subject.other | iron-folic acid | - |
dc.subject.other | mitochondrial DNA | - |
dc.subject.other | multiple micronutrients | - |
dc.subject.other | randomized controlled trial | - |
dc.subject.other | telomere length | - |
dc.title | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 15 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
local.relation.h2020 | 946192 | - |
dc.identifier.doi | 10.26599/FSHW.2024.9250304 | - |
local.provider.type | CrossRef | - |
local.uhasselt.international | yes | - |
item.fullcitation | Hanley-Cook, Giles T.; Bastos-Moreira, Yuri; MARTENS, Dries; Dailey-Chwalibóg, Trenton; Toe, Laeticia Celine; Kok, Brenda de; Ouédraogo, Lionel; Argaw, Alemayehu; Tesfamariam, Kokeb; Kolsteren, Patrick; Huybregts, Lieven; NAWROT, Tim; Saeger, Sarah De; Boevre, Marthe De & Lachat, Carl (2024) Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso. In: Food Science and Human Wellness, 15. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Hanley-Cook, Giles T. | - |
item.contributor | Bastos-Moreira, Yuri | - |
item.contributor | MARTENS, Dries | - |
item.contributor | Dailey-Chwalibóg, Trenton | - |
item.contributor | Toe, Laeticia Celine | - |
item.contributor | Kok, Brenda de | - |
item.contributor | Ouédraogo, Lionel | - |
item.contributor | Argaw, Alemayehu | - |
item.contributor | Tesfamariam, Kokeb | - |
item.contributor | Kolsteren, Patrick | - |
item.contributor | Huybregts, Lieven | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Saeger, Sarah De | - |
item.contributor | Boevre, Marthe De | - |
item.contributor | Lachat, Carl | - |
crisitem.journal.eissn | 2213-4530 | - |
Appears in Collections: | Research publications |
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Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content_ a randomized controlled efficacy trial in rural Burkina Faso.pdf Restricted Access | Early view | 995.06 kB | Adobe PDF | View/Open Request a copy |
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