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http://hdl.handle.net/1942/43610
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DC Field | Value | Language |
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dc.contributor.author | D'HAESE, Sarah | - |
dc.contributor.author | Claes, Lisa | - |
dc.contributor.author | Jaeken, Eva | - |
dc.contributor.author | DELUYKER, Dorien | - |
dc.contributor.author | EVENS, Lize | - |
dc.contributor.author | HEEREN, Ellen | - |
dc.contributor.author | HAESEN, Sibren | - |
dc.contributor.author | VASTMANS, Lotte | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | WOUTERS, Kristiaan | - |
dc.contributor.author | Schalkwijk, Casper | - |
dc.contributor.author | HANSEN, Dominique | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.contributor.author | BITO, Virginie | - |
dc.date.accessioned | 2024-08-29T12:37:56Z | - |
dc.date.available | 2024-08-29T12:37:56Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-08-16T13:51:11Z | - |
dc.identifier.citation | International journal of molecular sciences (Print), 25 (15) | - |
dc.identifier.uri | http://hdl.handle.net/1942/43610 | - |
dc.description.abstract | Individuals with type 2 diabetes mellitus (T2DM) are at an increased risk for heart failure, yet preventive cardiac care is suboptimal in this population. Pyridoxamine (PM), a vitamin B6 analog, has been shown to exert protective effects in metabolic and cardiovascular diseases. In this study, we aimed to investigate whether PM limits adverse cardiac remodeling and dysfunction in rats who develop T2DM. Male rats received a standard chow diet or Western diet (WD) for 18 weeks to induce prediabetes. One WD group received additional PM (1 g/L) via drinking water. Glucose tolerance was assessed with a 1 h oral glucose tolerance test. Cardiac function was evaluated using echocardiography and hemodynamic measurements. Histology on left ventricular (LV) tissue was performed. Treatment with PM prevented the increase in fasting plasma glucose levels compared to WD-fed rats (p < 0.05). LV cardiac dilation tended to be prevented using PM supplementation. In LV tissue, PM limited an increase in interstitial collagen deposition (p < 0.05) seen in WD-fed rats. PM tended to decrease 3-nitrotyrosine and significantly lowered 4-hydroxynonenal content compared to WD-fed rats. We conclude that PM alleviates interstitial fibrosis and oxidative stress in the hearts of WD-induced prediabetic rats. | - |
dc.description.sponsorship | Funding This research was funded by a grant of Bijzonder onderzoeksfonds (BOF) from Hasselt University (grant number 19KP09BOF) and a grant from The Research Foundation—Flanders (FWO, Brussels, Belgium) (grant number G095221FWO). Acknowledgments The authors thank Petra Bex for her skillful technical assistance with animal feeding, and Melissa Jans and Yennick Geunens for animal housing. We also thank Jeanine Santermans for embedding the tissues in paraffin and Marjo vande Waarenburg for her help with the Mesoscale Discovery measurements. The graphical abstract and experimental design figure was created using images from Biorender. | - |
dc.language.iso | en | - |
dc.rights | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | pyridoxamine | - |
dc.subject.other | type 2 diabetes | - |
dc.subject.other | Western diet | - |
dc.subject.other | adverse cardiac remodeling | - |
dc.subject.other | prevention | - |
dc.subject.other | cardioprotection | - |
dc.title | Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 15 | - |
dc.identifier.volume | 25 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.3390/ijms25158508 | - |
dc.identifier.isi | WOS:001287874900001 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.fullcitation | D'HAESE, Sarah; Claes, Lisa; Jaeken, Eva; DELUYKER, Dorien; EVENS, Lize; HEEREN, Ellen; HAESEN, Sibren; VASTMANS, Lotte; LAMBRICHTS, Ivo; WOUTERS, Kristiaan; Schalkwijk, Casper; HANSEN, Dominique; OP 'T EIJNDE, Bert & BITO, Virginie (2024) Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. In: International journal of molecular sciences (Print), 25 (15). | - |
item.contributor | D'HAESE, Sarah | - |
item.contributor | Claes, Lisa | - |
item.contributor | Jaeken, Eva | - |
item.contributor | DELUYKER, Dorien | - |
item.contributor | EVENS, Lize | - |
item.contributor | HEEREN, Ellen | - |
item.contributor | HAESEN, Sibren | - |
item.contributor | VASTMANS, Lotte | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | WOUTERS, Kristiaan | - |
item.contributor | Schalkwijk, Casper | - |
item.contributor | HANSEN, Dominique | - |
item.contributor | OP 'T EIJNDE, Bert | - |
item.contributor | BITO, Virginie | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1661-6596 | - |
crisitem.journal.eissn | 1422-0067 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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ijms-25-08508-v2.pdf | Published version | 3.81 MB | Adobe PDF | View/Open |
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