Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/43617
Full metadata record
DC FieldValueLanguage
dc.contributor.authorScalfari, Antonio-
dc.contributor.authorTraboulsee, Anthony-
dc.contributor.authorOh, Jiwon-
dc.contributor.authorAiras, Laura-
dc.contributor.authorBittner, Stefan-
dc.contributor.authorCalabrese, Massimiliano-
dc.contributor.authorGarcia Dominguez, Jose Manuel-
dc.contributor.authorGranziera, Cristina-
dc.contributor.authorGreenberg, Benjamin-
dc.contributor.authorHellwig, Kerstin-
dc.contributor.authorIlles, Zsolt-
dc.contributor.authorLycke, Jan-
dc.contributor.authorPOPESCU, Veronica-
dc.contributor.authorBagnato, Francesca-
dc.contributor.authorGiovannoni, Gavin-
dc.date.accessioned2024-09-02T07:18:12Z-
dc.date.available2024-09-02T07:18:12Z-
dc.date.issued2024-
dc.date.submitted2024-08-19T10:51:21Z-
dc.identifier.citationAnnals of neurology,-
dc.identifier.urihttp://hdl.handle.net/1942/43617-
dc.description.abstractDespite therapeutic suppression of relapses, multiple sclerosis (MS) patients often experience subtle deterioration, which extends beyond the definition of "progression independent of relapsing activity." We propose the concept of smouldering-associated-worsening (SAW), encompassing physical and cognitive symptoms, resulting from smouldering pathological processes, which remain unmet therapeutic targets. We provide a consensus-based framework of possible pathological substrates and manifestations of smouldering MS, and we discuss clinical, radiological, and serum/cerebrospinal fluid biomarkers for potentially monitoring SAW. Finally, we share considerations for optimizing disease surveillance and implications for clinical trials to promote the integration of smouldering MS into routine practice and future research efforts. ANN NEUROL 2024 image-
dc.description.sponsorshipThe concepts expressed in this manuscript, emerged from several advisory board meetings, facilitated by Sanofi, who kindly provided financial support to design the figures. The manuscript development, its contents, including the proposed concepts such as SAW, and the decision to publish were solely driven by the authors and not driven by any commercial interests of Sanofi. We acknowledge the support provided by Janneke van Wingerden of Sanofi for coordinating advisory board meetings and for reviewing the manuscript, and the Medical Writer support provided by Lionel Thevathasan MS FRCS from LT Associates, who was funded by Sanofi.-
dc.language.isoen-
dc.publisherWILEY-
dc.rights2024 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.-
dc.titleSmouldering-Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions-
dc.typeJournal Contribution-
local.format.pages19-
local.bibliographicCitation.jcatA1-
dc.description.notesScalfari, A (corresponding author), Charing Cross Hosp, Ctr Neurosci, Dept Med, Imperial Coll Fulham Palace Rd, London W6 8RF, England.-
dc.description.notesa.scalfari@imperial.ac.uk-
local.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA-
local.type.refereedRefereed-
local.type.specifiedReview-
local.bibliographicCitation.statusEarly view-
dc.identifier.doi10.1002/ana.27034-
dc.identifier.pmid39051525-
dc.identifier.isi001275591200001-
dc.contributor.orcidCalabrese, Massimiliano/0000-0002-3362-7403; Bittner,-
dc.contributor.orcidStefan/0000-0003-2179-3655-
local.provider.typewosris-
local.description.affiliation[Scalfari, Antonio] Charing Cross Hosp, Ctr Neurosci, Dept Med, Imperial Coll Fulham Palace Rd, London W6 8RF, England.-
local.description.affiliation[Traboulsee, Anthony] Univ British Columbia, Vancouver, BC, Canada.-
local.description.affiliation[Oh, Jiwon] Univ Toronto, St Michaels Hosp, Dept Med, Div Neurol, Toronto, ON, Canada.-
local.description.affiliation[Airas, Laura] Univ Turku, Turku, Finland.-
local.description.affiliation[Airas, Laura] Turku Univ Hosp, Turku, Finland.-
local.description.affiliation[Bittner, Stefan] Johannes Gutenberg Univ Mainz, Dept Neurol, Focus Program Translat Neurosci FTN & Immunotherap, Rhine Main Neurosci Network Rmn2,Univ Med Ctr, Mainz, Germany.-
local.description.affiliation[Calabrese, Massimiliano] Univ Hosp Verona, Verona, Italy.-
local.description.affiliation[Garcia Dominguez, Jose Manuel] Hosp Gen Univ Gregorio Maranon, Madrid, Spain.-
local.description.affiliation[Granziera, Cristina] Univ Basel, Fac Med, Dept Biomed Engn, Translat Imaging Neurol THiNK Basel, Basel, Switzerland.-
local.description.affiliation[Granziera, Cristina] Univ Hosp Basel, Dept Neurol, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Dept Biomed & Clin Res, Basel, Switzerland.-
local.description.affiliation[Granziera, Cristina] Univ Hosp Basel, MS Ctr, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Basel, Switzerland.-
local.description.affiliation[Greenberg, Benjamin] Univ Texas Southwestern, Dallas, TX USA.-
local.description.affiliation[Hellwig, Kerstin] Ruhr Univ Bochum, St Josef Hosp, Bochum, Germany.-
local.description.affiliation[Illes, Zsolt] Univ Southern Denmark, Odense Univ Hosp, Dept Neurol, Odense, Denmark.-
local.description.affiliation[Lycke, Jan] Univ Gothenburg, Sahlgrenska Acad, Dept Neurosci & Physiol, Gothenburg, Sweden.-
local.description.affiliation[Popescu, Veronica] Belgium Hasselt Univ, Univ MS Ctr Pelt Hasselt, Noorderhart Hosp, Pelt, Belgium.-
local.description.affiliation[Bagnato, Francesca] Vanderbilt Univ, Dept Neurol, Neuroimmunol Div, Neuroimaging Unit,Med Ctr, Nashville, TN USA.-
local.description.affiliation[Bagnato, Francesca] VA Hosp, Dept Neurol, TN Valley Healthcare Syst, Nashville, TN USA.-
local.description.affiliation[Giovannoni, Gavin] Queen Mary Univ London, Blizard Inst, Fac Med & Dent, London, England.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.contributorScalfari, Antonio-
item.contributorTraboulsee, Anthony-
item.contributorOh, Jiwon-
item.contributorAiras, Laura-
item.contributorBittner, Stefan-
item.contributorCalabrese, Massimiliano-
item.contributorGarcia Dominguez, Jose Manuel-
item.contributorGranziera, Cristina-
item.contributorGreenberg, Benjamin-
item.contributorHellwig, Kerstin-
item.contributorIlles, Zsolt-
item.contributorLycke, Jan-
item.contributorPOPESCU, Veronica-
item.contributorBagnato, Francesca-
item.contributorGiovannoni, Gavin-
item.fullcitationScalfari, Antonio; Traboulsee, Anthony; Oh, Jiwon; Airas, Laura; Bittner, Stefan; Calabrese, Massimiliano; Garcia Dominguez, Jose Manuel; Granziera, Cristina; Greenberg, Benjamin; Hellwig, Kerstin; Illes, Zsolt; Lycke, Jan; POPESCU, Veronica; Bagnato, Francesca & Giovannoni, Gavin (2024) Smouldering-Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions. In: Annals of neurology,.-
item.accessRightsOpen Access-
crisitem.journal.issn0364-5134-
crisitem.journal.eissn1531-8249-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
Annals of Neurology - 2024 - Scalfari - Smouldering‐Associated Worsening in Multiple Sclerosis An International Consensus.pdfEarly view2.71 MBAdobe PDFView/Open
Show simple item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.