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Title: | Comparative transcriptomics provides insights into molecular mechanisms of zinc tolerance in the ectomycorrhizal fungus Suillus luteus | Authors: | Smith, Alexander Fletcher, Jessica Swinnen , Janne Jonckheere, Karl Bazzicalupo, Anna Liao , Hui-Ling Ragland, Greg COLPAERT, Jan Lipzen, Anna Tejomurthula, Sravanthi Barry, Kerrie Grigoriev, Igor, V RUYTINX, Joske Branco, Sara |
Editors: | Rokas, A | Issue Date: | 2024 | Publisher: | OXFORD UNIV PRESS INC | Source: | G3 (Bethesda Md.), | Status: | Early view | Abstract: | Zinc (Zn) is a major soil contaminant and high Zn levels can disrupt growth, survival, and reproduction of fungi. Some fungal species evolved Zn tolerance through cell processes mitigating Zn toxicity, although the genes and detailed mechanisms underlying mycorrhizal fungal Zn tolerance remain unexplored. To fill this gap in knowledge, we investigated the gene expression of Zn tolerance in the ectomycorrhizal fungus Suillus luteus. We found that Zn tolerance in this species is mainly a constitutive trait that can also be environmentally dependent. Zinc tolerance in S. luteus is associated with differences in the expression of genes involved in metal exclusion and immobilization, as well as recognition and mitigation of metal-induced oxidative stress. Differentially expressed genes were predicted to be involved in transmembrane transport, metal chelation, oxidoreductase activity, and signal transduction. Some of these genes were previously reported as candidates for S. luteus Zn tolerance, while others are reported here for the first time. Our results contribute to understanding the mechanisms of fungal metal tolerance and pave the way for further research on the role of fungal metal tolerance in mycorrhizal associations. | Notes: | Branco, S (corresponding author), Univ Colorado Denver, Dept Integrat Biol, Denver, CO 80204 USA. sara.branco@ucdenver.edu |
Keywords: | gene expression;metal;zinc;stress;tolerance;fungi | Document URI: | http://hdl.handle.net/1942/43653 | ISSN: | 2160-1836 | e-ISSN: | 2160-1836 | DOI: | 10.1093/g3journal/jkae156 | ISI #: | 001279752900001 | Rights: | The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Comparative transcriptomics provides insights pdf.pdf | Early view | 786.5 kB | Adobe PDF | View/Open |
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