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Title: | Challenges and Opportunities in Establishing Appropriate Intermediate Endpoints Reflecting Patient Benefit: A Roadmap for Research and Clinical Application in Nonmetastatic Prostate Cancer | Authors: | Brookman-May, Sabine D. BUYSE, Marc Freedland, Stephen J. Miladinovic, Branko Zhang, Ke Fendler, Wolfgang P. Feng, Felix Sartor, Oliver Sweeney, Christopher J. |
Issue Date: | 2024 | Publisher: | ELSEVIER | Source: | European Urology, 86 (2) , p. 81 -87 | Abstract: | Defining meaningful endpoints for research of early-stage high-risk prostate cancer is challenging, with established measures such as overall survival and metastasis-free survival facing limitations related to feasibility and adequate reflection of patient relevance. Developing endpoints must cater to diverse perspectives across scientific, clinical, regulatory, and patient viewpoints. Endpoints such as pathological complete response, no evidence of disease, and prevention of prostate-specific antigen relapse may reflect patient benefit by accounting for diagnostic and treatment burdens. | Notes: | Brookman-May, SD (corresponding author), 58 Village Stn Circle, Plymouth Meeting, PA 19462 USA. sabine.brookman-may@email.de |
Keywords: | Humans;Male;Endpoint Determination;Prostate-Specific Antigen;Prostatic Neoplasms | Document URI: | http://hdl.handle.net/1942/43711 | ISSN: | 0302-2838 | e-ISSN: | 1873-7560 | DOI: | 10.1016/j.eururo.2024.04.024 | ISI #: | 001286909200001 | Rights: | 2024 European Association of Urology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies. | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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