Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/43721
Title: | Consecutive or selectively included high bleeding risk patients in the MASTER DAPT screening log and trial | Authors: | Landi, Antonio Heg, Dik Frigoli, Enrico Tonino, Pim A. L. VRANCKX, Pascal Pourbaix, Suzanne Chevalier, Bernard Iniguez, Andres Pinar, Eduardo Lesiak, Maciej Kala, Petr Donahue, Michael Windecker, Stephan Roffi, Marco Smits, Pieter C. Valgimigli, Marco |
Issue Date: | 2024 | Publisher: | ELSEVIER | Source: | European journal of internal medicine (Leicester), 126 , p. 89 -94 | Abstract: | Aims: Screening logs have the potential to appraise the actual prevalence and distribution of predefined patient subsets, avoiding selection biases, which are inevitably and potentially present in randomised trials and real- world registries, respectively. We aimed to assess the prevalence of high bleeding risk (HBR) characteristics in the real world and the external validity of the MASTER DAPT trial. Methods and results: All consecutive patients who underwent percutaneous coronary intervention (PCI) for at least two consecutive weeks across 65 sites participating in the trial were entered into a screening log. Of 2,847 consecutive patients, 1,098 (38.6 %) were HBR and 109 (9.9 %) consented for trial participation. PRECISE-DAPT score > 25 was the most frequent HBR feature, followed by advanced age, use of oral anticoagulation (OAC) and anaemia. Compared with consecutive HBR patients, consenting patients were older (> > 75 years: 69 % versus 62 %, absolute standardized difference [SD] 0.16), more frequently male (78 % versus 71 %, absolute SD 0.18), had higher use of OAC (38 % versus 20 %, absolute SD 0.39), treatment with steroids or nonsteroidal antiinflammatory drugs (10 % versus 5 %, SD 0.16), and prior cerebrovascular events (10 % versus 6 %, , absolute SD 0.18) but lower PRECISE DAPT score > 25 (54 % versus 66 %, absolute SD 0.24). Conclusions: The HBR criteria distribution differed between consecutive versus selectively included HBR patients, suggesting the existence of selection biases in the trial population. | Notes: | Valgimigli, M (corresponding author), Ente Osped Cantonale, Cardioctr Ticino Inst, Via Tesserete 48, CH-6900 Lugano, Switzerland. marco.valgimigli@eoc.ch |
Keywords: | High bleeding risk;Antiplatelet therapy;Dual antiplatelet therapy;Percutaneous coronary intervention | Document URI: | http://hdl.handle.net/1942/43721 | ISSN: | 0953-6205 | e-ISSN: | 1879-0828 | DOI: | 10.1016/j.ejim.2024.04.016 | ISI #: | 001287622700001 | Rights: | 2024 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Consecutive or selectively included high bleeding risk patients in the MASTER DAPT screening log and trial.pdf Restricted Access | Published version | 1.26 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.