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Title: | Association between trimester-specific prenatal air pollution exposure and placental weight of twins | Authors: | Boehm-Gonzalez, Simone Teresa Ziemendorff, Alischa Meireson, Eline Weyers, Steven NAWROT, Tim BIJNENS, Esmee Gielen , Marij |
Issue Date: | 2024 | Publisher: | W B SAUNDERS CO LTD | Source: | Placenta (Eastbourne), 154 , p. 207 -215 | Abstract: | Introduction: This study investigates the association between maternal exposure to particulate matter (PM10) and nitric dioxide (NO2) during the first, second and third trimester and placental weight and birth weight/placental weight (BW/PW) ratio in twins at birth. Methods: Cross-sectional data of 3340 twins from the East Flanders Prospective Twin Survey was used. Air pollutant exposure was estimated via spatial temporal interpolation. Univariable and multivariable mixed model analyses with a random intercept to account for the relatedness of newborns were conducted for twins with separate placentas. Twin pairs with one placental mass were studied with linear and logistic regression. Results: In the third trimester, for each 10 mu m/m(3) increase in PM10 or NO2 placental weight decreased -19.7 g (95%-C.I. -35.1; -4.3) and -17.7 g (95%-C.I. -30.4; -0.5) respectively, in moderate to late preterm twins with separate placentas. Consequently, BW/PW ratio increased with higher air pollution exposure. PM10 exposure in the last week of pregnancy was associated with a higher odds ratio (OR) of 1.20 (95%-C.I. 1.00; 1.44) for a "small for gestational age placenta" (placental weight <10th percentile). Conversely, first trimester air pollutant exposure was associated with lower ORs of 0.55 (95%-C.I. 0.35; 0.88) and 0.60 (95%-C.I. 0.42; 0.84). Discussion: The association of PM10 and NO2 on placental weight is trimester-specific, differs for twins with one versus two placentas and is most pronounced in moderate to late preterm twins. Longitudinal studies are needed to better understand the relationship between air pollutant exposure and placental weight evolution across different trimesters. | Notes: | Gielen, M (corresponding author), Maastricht Univ, NUTRIM Sch Translat Res Metab, Dept Epidemiol, POB 616, NL-6200 MD Maastricht, Netherlands. simone.boehm-gonzalez@uk-koeln.de; a.ziemendorff@posteo.de; Eline.Meireson@uzgent.be; Steven.Weyers@uzgent.be; tim.nawrot@uhasselt.be; esmee.bijnens@uhasselt.be; marij.gielen@maastrichuniversity.nl |
Keywords: | Air pollution;Particulate matter;Prenatal exposure;Placental weight;Trimester;Twin | Document URI: | http://hdl.handle.net/1942/43725 | ISSN: | 0143-4004 | e-ISSN: | 1532-3102 | DOI: | 10.1016/j.placenta.2024.07.309 | ISI #: | 001285394000001 | Rights: | 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Association between trimester-specific prenatal air pollution exposure and placental weight of twins.pdf | Published version | 436 kB | Adobe PDF | View/Open |
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