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Title: | Geographical Variations in the Effectiveness and Safety of Abbreviated or Standard Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients at High Bleeding Risk | Authors: | Ozaki, Yukio Hong, Sung-Jin Heg, Dik Frigoli, Enrico VRANCKX, Pascal Morice, Marie-Claude Chevalier, Bernard Onuma, Yoshinobu Windecker, Stephan Di Biasi, Maurizio Whitbourn, Robert Dudek, Dariusz Raffel, Owen Christopher Shimizu, Kiyokazu Calabro, Paolo Frobert, Ole Cura, Fernando Ten Berg, Jurrien Smits, Pieter C. Valgimigli, Marco |
Issue Date: | 2024 | Publisher: | ELSEVIER SCIENCE INC | Source: | Canadian Journal of Cardiology, 40 (9) , p. 1671 -1674 | Abstract: | In high bleeding risk (HBR) patients, noninferiority of 1month dual antiplatelet therapy (APT) to treatment continuation for double dagger 2 additional months for the occurrence of net and major adverse clinical events after drug-eluting stent implantation was shown in the Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Ste nt Implantation With an Abbreviated Versus Prolonged DAPT Regimen (MASTER DAPT) trial.1 1 A significant fi cant reduction in bleeding was also noted. However, whether these treatment effects of APT are consistent across geographical regions remains uncertain. In the present analyses, the effects of abbreviated or standard APT on the 1-year occurrence of net and major adverse clinical events and bleeding were consistent across geographical regions (Europe, East Asia, and others). [Clinical Trial Registration: https://www.clinicaltrials.gov. Unique identifier: fi er: NCT03023020]. | Notes: | Valgimigli, M (corresponding author), Univ Svizzera Italiana USI, Cardioctr Inst, Ente Osped Cantonale, CH-6900 Lugano, Switzerland. marco.valgimigli@cardiocentro.org |
Keywords: | Humans;Hemorrhage;Treatment Outcome;Male;Percutaneous Coronary Intervention;Platelet Aggregation Inhibitors | Document URI: | http://hdl.handle.net/1942/44434 | ISSN: | 0828-282X | e-ISSN: | 1916-7075 | DOI: | 10.1016/j.cjca.2024.01.032 | ISI #: | 001313457800001 | Rights: | 2024 Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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