Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/44664
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dc.contributor.authorLIBBERECHT, Karen-
dc.contributor.authorJEURISSEN, Hanne-
dc.contributor.authorDIRKX, Nathalie-
dc.contributor.authorHASEVOETS, Steffie-
dc.contributor.authorKUIPERS, Koen-
dc.contributor.authorPrior, Robert-
dc.contributor.authorHERMANS, Florian-
dc.contributor.authorFluiter, Kees-
dc.contributor.authorBaas, Frank-
dc.contributor.authorLAMBRICHTS, Ivo-
dc.contributor.authorVANGANSEWINKEL, Tim-
dc.contributor.authorVan Den Bosch , Ludo-
dc.contributor.authorWOLFS, Esther-
dc.date.accessioned2024-11-15T08:59:58Z-
dc.date.available2024-11-15T08:59:58Z-
dc.date.issued2024-
dc.date.submitted2024-10-25T12:38:20Z-
dc.identifier.citationJournal of the peripheral nervous system, 29 (S3) , p. S33 (Art N° P077)-
dc.identifier.urihttp://hdl.handle.net/1942/44664-
dc.description.abstractConclusions: We have identified a novel promyelinating factor, PAK2, that acts as a critical convergence point for multiple promyelinating signaling pathways. The promyelination by PAK2 is Schwann cell-autonomous. Myelin lipids, identified as inhibitors or activators of PAK2, may be utilized to develop therapies for repairing abnormal myelin in peripheral neuropathies.-
dc.description.sponsorshipResearch Foundation Flanders"(Fonds Wetenschappelijk Onderzoek-
dc.language.isoen-
dc.publisherWILEY-
dc.subject.otherCharcot Marie Tooth disease-
dc.subject.otherSchwann cells-
dc.subject.otherlysosomal alterations-
dc.subject.othercathepsin release-
dc.subject.otherpatient-derived iPSC-
dc.titleDisruption of lysosomal homeostatis and extracellular cathepsin release by Schwann cells in Charcot-Marie-tooth disease type 1A-
dc.typeJournal Contribution-
dc.identifier.issueS3-
dc.identifier.spageS33-
dc.identifier.volume29-
local.format.pages1-
local.bibliographicCitation.jcatM-
local.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA-
local.type.refereedRefereed-
local.type.specifiedMeeting Abstract-
local.bibliographicCitation.artnrP077-
dc.identifier.doi10.1111/jns.12648-
dc.identifier.isi001319566000062-
local.provider.typewosris-
local.description.affiliation[Libberecht, Karen; Jeurissen, Hanne; Dirkx, Nathalie; Kuipers, Koen; Vangansewinkel, Tim; Wolfs, Esther] UHasselt, Lab Funct Imaging & Res Stem Cells, Diepenbeek, Belgium.-
local.description.affiliation[Libberecht, Karen; Vangansewinkel, Tim; Van Den Bosch, Ludo] VIB, Ctr Brain & Dis Res, Lab Neurobiol, Leuven, Belgium.-
local.description.affiliation[Hasevoets, Steffie; Hermans, Florian] UHasselt, Lab Res Ischem Stroke Stem Cells & Angiogenesis, Diepenbeek, Belgium.-
local.description.affiliation[Kuipers, Koen] UHasselt, Dept Immunol & Infect, Diepenbeek, Belgium.-
local.description.affiliation[Prior, Robert] Univ Bonn, Med Fac, Dept Ophthalmol, Bonn, Germany.-
local.description.affiliation[Fluiter, Kees; Baas, Frank] Leiden Univ, Leiden Univ Med Ctr, Dept Clin Genet, Leiden, Netherlands.-
local.description.affiliation[Lambrichts, Ivo; Vangansewinkel, Tim] UHasselt, Lab Histol & Regenerat, Diepenbeek, Belgium.-
local.description.affiliation[Van Den Bosch, Ludo] Katholieke Univ Leuven, Dept Neurosci, Expt Neurol & Leuven Brain Ins LBI, Leuven, Belgium.-
local.uhasselt.internationalyes-
item.contributorLIBBERECHT, Karen-
item.contributorJEURISSEN, Hanne-
item.contributorDIRKX, Nathalie-
item.contributorHASEVOETS, Steffie-
item.contributorKUIPERS, Koen-
item.contributorPrior, Robert-
item.contributorHERMANS, Florian-
item.contributorFluiter, Kees-
item.contributorBaas, Frank-
item.contributorLAMBRICHTS, Ivo-
item.contributorVANGANSEWINKEL, Tim-
item.contributorVan Den Bosch , Ludo-
item.contributorWOLFS, Esther-
item.fullcitationLIBBERECHT, Karen; JEURISSEN, Hanne; DIRKX, Nathalie; HASEVOETS, Steffie; KUIPERS, Koen; Prior, Robert; HERMANS, Florian; Fluiter, Kees; Baas, Frank; LAMBRICHTS, Ivo; VANGANSEWINKEL, Tim; Van Den Bosch , Ludo & WOLFS, Esther (2024) Disruption of lysosomal homeostatis and extracellular cathepsin release by Schwann cells in Charcot-Marie-tooth disease type 1A. In: Journal of the peripheral nervous system, 29 (S3) , p. S33 (Art N° P077).-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
crisitem.journal.issn1085-9489-
crisitem.journal.eissn1529-8027-
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