Investigating ferroptosis and altered antioxidant signaling in Charcot-Marie-Tooth disease typy 1A

Abstract

addition, we confirmed a significant reduction in the expression of GDAP1 within patient-derived cells, providing a direct link to disease pathology. Our preliminary functional assessments revealed that GDAP1 mutation had a discernible impact within the spheroid model. Conclusions: Overall, our study highlights the importance of developing physiologically relevant models for a deeper understanding of CMT and the pursuit of effective treatments. Building on these findings , our future endeavors will aim to further enhance the complexity of our model system by establishing an all-human in vitro neuromus-cular junction in a customized microfluidic chip.