Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/44670
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dc.contributor.authorJayne, Sandrine-
dc.contributor.authorLopez, Cristina-
dc.contributor.authorPUT, Natalie-
dc.contributor.authorNagel, Inga-
dc.contributor.authorLierman, Els-
dc.contributor.authorPenas, Eva Maria Murga-
dc.contributor.authorMichaux, Lucienne-
dc.contributor.authorAhearne, Matthew J.-
dc.contributor.authorWalter, Harriet S.-
dc.contributor.authorBens , Susanne-
dc.contributor.authorDrewes, Cosima-
dc.contributor.authorSzczepanowski, Monika-
dc.contributor.authorSchlesner, Matthias-
dc.contributor.authorRosenstiel, Philip-
dc.contributor.authorWlodarska, Iwona-
dc.contributor.authorSiebert, Reiner-
dc.contributor.authorDyer, Martin J. S.-
dc.date.accessioned2024-11-18T10:13:54Z-
dc.date.available2024-11-18T10:13:54Z-
dc.date.issued2024-
dc.date.submitted2024-11-08T12:58:42Z-
dc.identifier.citationBritish journal of haematology (Print),-
dc.identifier.urihttp://hdl.handle.net/1942/44670-
dc.description.abstractThe chromosomal translocation t(1;6)(p35.3;p25.2) is a rare but recurrent aberration in chronic lymphocytic leukaemia (CLL). We report molecular characterization of 10 cases and show that this translocation juxtaposes interferon regulatory factor 4 (IRF4) on 6p25 with regulator of chromosome condensation 1 (RCC1) on 1p35. The breakpoints fell within the 5 ' untranslated regions of both genes, resulting in RCC1::IRF4 fusion transcripts without alterations of the protein-coding sequences. Levels of expression of both RCC1 and IRF4 proteins were not obviously deregulated. The cases showed other mutations typical of CLL and we confirm previously reported skewing towards the IGHV-unmutated subtype. RCC1::IRF4 fusion characterizes a rare subset of CLL.-
dc.description.sponsorshipFunding information Cancer Research UK in conjunction with the UK Department of Health on an Experimental Cancer Medicine Centre grant, Grant/Award Number: C10604/A25151; Departament d’Empresa i Coneixement de la Generalitat de Catalunya, Grant/Award Number: postdoctoral Beatriu de Pinós grant; Deutsche Forschungsgemeinschaft, Grant/Award Number: SFB1074 (project B10N); Stichting tegen Kanker; German Ministry of Science and Education, Grant/Award Number: 01KU1002A-J and ICGC MMML-Seq; Bundersministerium fur Bildung und Forschung (BMBF), Grant/Award Number: 01KU1505E, 01KU1505G and ICGC DE-Mining; HORIZON EUROPE Marie Sklodowska-Curie Actions, Grant/Award Number: 2018-BP-00055; Fonds Wetenschappelijk Onderzoek; ScottWaudby Trust. ACKNOWLEDGEMENTS The authors would like to thank B. Rai, M. M. Tzioni, H. Lemmens, H. Vranckx, W. De Kelver and all laboratory technicians for excellent technical assistance. We thank our clinical colleagues for kindly referring patients for this study. We thank all the members of the ICGC MMML-Seq and ICGC DE-Mining Projects.-
dc.language.isoen-
dc.publisherWILEY-
dc.rights2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.-
dc.subject.otherchromosomal translocation-
dc.subject.otherCLL-
dc.subject.otherIRF4-
dc.titleThe chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion-
dc.typeJournal Contribution-
local.format.pages6-
local.bibliographicCitation.jcatA1-
dc.description.notesDyer, MJS (corresponding author), Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester Canc Res Ctr, Leicester LE1 9HN, England.-
dc.description.notesmjsd1@leicester.ac.uk-
local.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.statusEarly view-
dc.identifier.doi10.1111/bjh.19790-
dc.identifier.pmid39406248-
dc.identifier.isi001339261500001-
dc.contributor.orcidJayne, Sandrine/0000-0003-1870-9782-
local.provider.typewosris-
local.description.affiliation[Jayne, Sandrine; Ahearne, Matthew J.; Walter, Harriet S.; Dyer, Martin J. S.] Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester Canc Res Ctr, Leicester LE1 9HN, England.-
local.description.affiliation[Lopez, Cristina; Nagel, Inga; Penas, Eva Maria Murga; Bens, Susanne] Christian Albrechts Univ Kiel, Inst Human Genet, Campus Kiel, Kiel, Germany.-
local.description.affiliation[Lopez, Cristina; Nagel, Inga; Penas, Eva Maria Murga; Bens, Susanne] Univ Hosp Schleswig Holstein, Campus Kiel, Kiel, Germany.-
local.description.affiliation[Lopez, Cristina; Bens, Susanne; Drewes, Cosima; Siebert, Reiner] Univ Ulm, Inst Human Genet, Ulm, Germany.-
local.description.affiliation[Lopez, Cristina; Bens, Susanne; Drewes, Cosima; Siebert, Reiner] Ulm Univ Med Ctr, Ulm, Germany.-
local.description.affiliation[Lopez, Cristina] Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain.-
local.description.affiliation[Lopez, Cristina; Wlodarska, Iwona] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.-
local.description.affiliation[Lopez, Cristina] Univ Barcelona, Barcelona, Spain.-
local.description.affiliation[Put, Natalie; Lierman, Els; Michaux, Lucienne] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium.-
local.description.affiliation[Put, Natalie] Ziekenhuis Oost Limburg, Dept Oncol Hematol & Radiotherapy, Genk, Belgium.-
local.description.affiliation[Put, Natalie] Limburgs Oncol Ctr, Genk, Belgium.-
local.description.affiliation[Put, Natalie] UHasselt Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium.-
local.description.affiliation[Szczepanowski, Monika] Christian Albrechts Univ Kiel, UKSH, Kiel, Germany.-
local.description.affiliation[Szczepanowski, Monika] Univ Hosp Schleswig Holstein, Dept Med 2, Campus Kiel, Kiel, Germany.-
local.description.affiliation[Schlesner, Matthias] German Canc Res Ctr, Bioinformat & Om Data Analyt B240, Heidelberg, Germany.-
local.description.affiliation[Schlesner, Matthias] Univ Augsburg, Biomed Informat Data Min & Data Analyt, Augsburg, Germany.-
local.description.affiliation[Rosenstiel, Philip] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.fullcitationJayne, Sandrine; Lopez, Cristina; PUT, Natalie; Nagel, Inga; Lierman, Els; Penas, Eva Maria Murga; Michaux, Lucienne; Ahearne, Matthew J.; Walter, Harriet S.; Bens , Susanne; Drewes, Cosima; Szczepanowski, Monika; Schlesner, Matthias; Rosenstiel, Philip; Wlodarska, Iwona; Siebert, Reiner & Dyer, Martin J. S. (2024) The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion. In: British journal of haematology (Print),.-
item.contributorJayne, Sandrine-
item.contributorLopez, Cristina-
item.contributorPUT, Natalie-
item.contributorNagel, Inga-
item.contributorLierman, Els-
item.contributorPenas, Eva Maria Murga-
item.contributorMichaux, Lucienne-
item.contributorAhearne, Matthew J.-
item.contributorWalter, Harriet S.-
item.contributorBens , Susanne-
item.contributorDrewes, Cosima-
item.contributorSzczepanowski, Monika-
item.contributorSchlesner, Matthias-
item.contributorRosenstiel, Philip-
item.contributorWlodarska, Iwona-
item.contributorSiebert, Reiner-
item.contributorDyer, Martin J. S.-
item.accessRightsOpen Access-
crisitem.journal.issn0007-1048-
crisitem.journal.eissn1365-2141-
Appears in Collections:Research publications
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