Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/44792
Title: Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders
Authors: LOIX, Melanie 
VANHERLE, Sam 
Turri, Marta
Kemp, Stephan
Fernandes, Karl J. L.
HENDRIKS, Jerome 
BOGIE, Jeroen 
Issue Date: 2024
Publisher: BMC
Source: Molecular neurodegeneration, 19 (1) (Art N° 85)
Abstract: Disturbances in the fatty acid lipidome are increasingly recognized as key drivers in the progression of various brain disorders. In this review article, we delve into the impact of Δ9 fatty acid desaturases, with a particular focus on stearoyl-CoA desaturase-1 (SCD1), within the setting of neuroinflammation, neurodegeneration, and brain repair. Over the past years, it was established that inhibition or deficiency of SCD1 not only suppresses neuroinflammation but also protects against neurodegeneration in conditions such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. This protective effect is achieved through different mechanisms including enhanced remyelination, reversal of synaptic and cognitive impairments, and mitigation of α-synuclein toxicity. Intriguingly, metabolic rerouting of fatty acids via SCD1 improves the pathology associated with X-linked adrenoleukodystrophy, suggesting context-dependent benign and harmful effects of SCD1 inhibition in the brain. Here, we summarize and discuss the cellular and molecular mechanisms underlying both the beneficial and detrimental effects of SCD1 in these neurological disorders. We explore commonalities and distinctions, shedding light on potential therapeutic challenges. Additionally, we touch upon future research directions that promise to deepen our understanding of SCD1 biology in brain disorders and potentially enhance the clinical utility of SCD1 inhibitors.
Keywords: Neurodegenerative disorders;Fatty acid metabolism;Stearoyl-CoA desaturases;Cellular and molecular dysfunction
Document URI: http://hdl.handle.net/1942/44792
e-ISSN: 1750-1326
DOI: 10.1186/s13024-024-00778-w
ISI #: 001358949300001
Rights: The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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