Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/44823
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dc.contributor.authorLOUWIES, Tijs-
dc.contributor.authorDE BOEVER, Patrick-
dc.contributor.authorHasso, Robin-
dc.contributor.authorTremblay, Malcom F.-
dc.contributor.authorXu, Da-
dc.contributor.authorBlaber, Andrew P.-
dc.contributor.authorGoswami, Nandu-
dc.date.accessioned2024-12-10T08:12:16Z-
dc.date.available2024-12-10T08:12:16Z-
dc.date.issued2024-
dc.date.submitted2024-12-04T14:17:11Z-
dc.identifier.citationNpj Microgravity, 10 (1) (Art N° 105)-
dc.identifier.urihttp://hdl.handle.net/1942/44823-
dc.description.abstractLong-term human spaceflight can lead to cardiovascular deconditioning, but little is known about how weightlessness affects microcirculation. In this study, we examined how the retinal microvessels and cerebrovascular regulation of 19 healthy male participants responded to long-term head-down bedrest (HDBR), an earth-based analog for weightlessness. In addition, we examined whether an anti-inflammatory/antioxidant cocktail could prevent the vascular changes caused by HDBR. In all study participants, we found a decrease in retinal arteriolar diameter by HDBR day 8 and an increase in retinal venular diameter by HDBR day 16. Concurrently, blood pressure at the level of the middle cerebral artery and the cerebrovascular resistance index were higher during HDBR, while cerebral blood flow velocity was lower. None of these changes were reversed in participants receiving the anti-inflammatory/antioxidant cocktail, indicating that this cocktail was insufficient to restore the microvascular and cerebral blood flow changes induced by HDBR.-
dc.description.sponsorshipWe thank the devoted participants without whom this study would not have been possible. This project was supported through a grant from the Canadian Space Agency (A.P.B.). The bedrest facility was supported by the European Space Agency and the Centre National d’Etudes Spatiales.-
dc.language.isoen-
dc.publisherNATURE PORTFOLIO-
dc.rightsThe Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.-
dc.titleRetinal blood vessel diameter changes with 60-day head-down bedrest are unaffected by antioxidant nutritional cocktail-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume10-
local.format.pages7-
local.bibliographicCitation.jcatA1-
local.publisher.placeHEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr105-
dc.identifier.doi10.1038/s41526-024-00443-y-
dc.identifier.pmid39548129-
dc.identifier.isi001355480000001-
dc.contributor.orcidGoswami, Nandu/0000-0002-6704-0723; De Boever,-
dc.contributor.orcidPatrick/0000-0002-5197-8215-
local.provider.typewosris-
local.uhasselt.internationalyes-
item.contributorLOUWIES, Tijs-
item.contributorDE BOEVER, Patrick-
item.contributorHasso, Robin-
item.contributorTremblay, Malcom F.-
item.contributorXu, Da-
item.contributorBlaber, Andrew P.-
item.contributorGoswami, Nandu-
item.fullcitationLOUWIES, Tijs; DE BOEVER, Patrick; Hasso, Robin; Tremblay, Malcom F.; Xu, Da; Blaber, Andrew P. & Goswami, Nandu (2024) Retinal blood vessel diameter changes with 60-day head-down bedrest are unaffected by antioxidant nutritional cocktail. In: Npj Microgravity, 10 (1) (Art N° 105).-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
crisitem.journal.eissn2373-8065-
Appears in Collections:Research publications
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